Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride in exposed workers
(1994) In Scandinavian Journal of Work, Environment and Health 20(6). p.459-465- Abstract
- OBJECTIVES--Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride (HHPA) was studied in exposed workers. METHODS--The relation between exposure to HHPA and the levels of specific immunoglobin E [(radioallergosorbent test (RAST)] and immunoglobin G (enzyme-linked immunosorbent assay) antibodies was investigated in a cross-sectional study on 95 workers from two plants using epoxy resin with HHPA as a hardener; the mean time of exposure was 7 (range 0.1-25) years. RESULTS--The specific immunoglobin E and immunoglobin G was significantly increased in exposed workers when they were compared with unexposed workers or external referents. There was no significant difference in the number of RAST... (More)
- OBJECTIVES--Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride (HHPA) was studied in exposed workers. METHODS--The relation between exposure to HHPA and the levels of specific immunoglobin E [(radioallergosorbent test (RAST)] and immunoglobin G (enzyme-linked immunosorbent assay) antibodies was investigated in a cross-sectional study on 95 workers from two plants using epoxy resin with HHPA as a hardener; the mean time of exposure was 7 (range 0.1-25) years. RESULTS--The specific immunoglobin E and immunoglobin G was significantly increased in exposed workers when they were compared with unexposed workers or external referents. There was no significant difference in the number of RAST positives [N = 23 (24%)] between the groups of workers exposed to < 10 micrograms.m-3, 10--< 50 micrograms.m-3, or > or = 50 micrograms.m-3. No effects were found of atopy or smoking habits on the prevalence of RAST positives. Five out of seven workers positive for immunoglobulin E in the group with the lowest exposures reported frequent short-time (minutes per day) exposures exceeding 50 micrograms.m-3. A correlation was seen between specific immunoglobulin E and G antibodies (rs = 0.5). CONCLUSIONS--The results indicate that HHPA is a sensitizing compound even at low exposure levels and that short-time peak exposures may have an impact on immunoglobulin E sensitization. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107874
- author
- Welinder, Hans LU ; Jönsson, Bo A LU ; Nielsen, Jörn LU ; Ottosson, Helene LU and Vidén, Cecilia LU
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Work, Environment and Health
- volume
- 20
- issue
- 6
- pages
- 459 - 465
- publisher
- Finnish Institute of Occupational Health
- external identifiers
-
- pmid:7701292
- scopus:0028608046
- ISSN
- 0355-3140
- language
- English
- LU publication?
- yes
- id
- 96f447fd-70d7-4235-95f5-5ca991fea27d (old id 1107874)
- date added to LUP
- 2016-04-01 11:45:32
- date last changed
- 2021-02-07 05:39:52
@article{96f447fd-70d7-4235-95f5-5ca991fea27d, abstract = {{OBJECTIVES--Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride (HHPA) was studied in exposed workers. METHODS--The relation between exposure to HHPA and the levels of specific immunoglobin E [(radioallergosorbent test (RAST)] and immunoglobin G (enzyme-linked immunosorbent assay) antibodies was investigated in a cross-sectional study on 95 workers from two plants using epoxy resin with HHPA as a hardener; the mean time of exposure was 7 (range 0.1-25) years. RESULTS--The specific immunoglobin E and immunoglobin G was significantly increased in exposed workers when they were compared with unexposed workers or external referents. There was no significant difference in the number of RAST positives [N = 23 (24%)] between the groups of workers exposed to < 10 micrograms.m-3, 10--< 50 micrograms.m-3, or > or = 50 micrograms.m-3. No effects were found of atopy or smoking habits on the prevalence of RAST positives. Five out of seven workers positive for immunoglobulin E in the group with the lowest exposures reported frequent short-time (minutes per day) exposures exceeding 50 micrograms.m-3. A correlation was seen between specific immunoglobulin E and G antibodies (rs = 0.5). CONCLUSIONS--The results indicate that HHPA is a sensitizing compound even at low exposure levels and that short-time peak exposures may have an impact on immunoglobulin E sensitization.}}, author = {{Welinder, Hans and Jönsson, Bo A and Nielsen, Jörn and Ottosson, Helene and Vidén, Cecilia}}, issn = {{0355-3140}}, language = {{eng}}, number = {{6}}, pages = {{459--465}}, publisher = {{Finnish Institute of Occupational Health}}, series = {{Scandinavian Journal of Work, Environment and Health}}, title = {{Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride in exposed workers}}, volume = {{20}}, year = {{1994}}, }