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Radio-immunotherapy dosimetry with special emphasis on SPECT quantification and extracorporeal immuno-adsorption

Strand, Sven-Erik LU ; Ljungberg, Michael LU ; Tennvall, Jan LU ; Norrgren, Kristina LU and Garkavij, Michael LU (1994) In Medical & Biological Engineering & Computing 32(5). p.551-561
Abstract
Results from therapeutic trials with radiolabelled monoclonal antibodies are difficult to compare, because of lack of accurate macroscopic and microscopic dosimetry for both tumours and normal tissues. Requirements for such a dosimetry are covered in the paper. Accurate in vivo dosimetric measurement techniques for verification of calculated absorbed doses are also needed to verify treatment planning. In the review, important topics related to dosimetry in therapeutic trials in RIT are covered, such as, absorbed-dose calculations and activity-quantification techniques for planar imaging and SPECT. The latter is particularly discussed, including a summary of different correction techniques. Absorbed-dose calculations and treatment-planning... (More)
Results from therapeutic trials with radiolabelled monoclonal antibodies are difficult to compare, because of lack of accurate macroscopic and microscopic dosimetry for both tumours and normal tissues. Requirements for such a dosimetry are covered in the paper. Accurate in vivo dosimetric measurement techniques for verification of calculated absorbed doses are also needed to verify treatment planning. In the review, important topics related to dosimetry in therapeutic trials in RIT are covered, such as, absorbed-dose calculations and activity-quantification techniques for planar imaging and SPECT. The latter is particularly discussed, including a summary of different correction techniques. Absorbed-dose calculations and treatment-planning techniques are also discussed. Possible ways of enhancing the therapeutic ratio are reviewed, especially the novel technique with extracorporeal immuno-adsorption. The review could form the basis of the development of future treatment-planning protocols and for dosimetry calculations in radio-immunotherapy, considering some of the most important parameters for approaching an accurate in vivo dosimetry. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Absorbed dose, Attenuation correction, Extracorporeal immuno-adsorption, Quantification, Radio-immunotherapy, Scatter, SPECT
in
Medical & Biological Engineering & Computing
volume
32
issue
5
pages
551 - 561
publisher
Springer
external identifiers
  • pmid:7845072
  • scopus:0028501288
ISSN
0140-0118
DOI
10.1007/BF02515314
language
English
LU publication?
yes
id
81ccef04-d227-45de-9211-d5748db8d29d (old id 1107971)
date added to LUP
2008-07-23 10:35:48
date last changed
2017-01-01 07:21:31
@article{81ccef04-d227-45de-9211-d5748db8d29d,
  abstract     = {Results from therapeutic trials with radiolabelled monoclonal antibodies are difficult to compare, because of lack of accurate macroscopic and microscopic dosimetry for both tumours and normal tissues. Requirements for such a dosimetry are covered in the paper. Accurate in vivo dosimetric measurement techniques for verification of calculated absorbed doses are also needed to verify treatment planning. In the review, important topics related to dosimetry in therapeutic trials in RIT are covered, such as, absorbed-dose calculations and activity-quantification techniques for planar imaging and SPECT. The latter is particularly discussed, including a summary of different correction techniques. Absorbed-dose calculations and treatment-planning techniques are also discussed. Possible ways of enhancing the therapeutic ratio are reviewed, especially the novel technique with extracorporeal immuno-adsorption. The review could form the basis of the development of future treatment-planning protocols and for dosimetry calculations in radio-immunotherapy, considering some of the most important parameters for approaching an accurate in vivo dosimetry.},
  author       = {Strand, Sven-Erik and Ljungberg, Michael and Tennvall, Jan and Norrgren, Kristina and Garkavij, Michael},
  issn         = {0140-0118},
  keyword      = {Absorbed dose,Attenuation correction,Extracorporeal immuno-adsorption,Quantification,Radio-immunotherapy,Scatter,SPECT},
  language     = {eng},
  number       = {5},
  pages        = {551--561},
  publisher    = {Springer},
  series       = {Medical & Biological Engineering & Computing},
  title        = {Radio-immunotherapy dosimetry with special emphasis on SPECT quantification and extracorporeal immuno-adsorption},
  url          = {http://dx.doi.org/10.1007/BF02515314},
  volume       = {32},
  year         = {1994},
}