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Neuropeptide Y in sympathetic co-transmission: recent advances in the search for neuropeptide Y antagonists

Edvinsson, Lars LU ; Erlinge, David LU ; Sun, X Y and Hedner, T (1994) In Pharmacology and Toxicology 74(4-5). p.193-201
Abstract
Since the discovery of neuropeptide Y which is co-stored and co-operate with noradrenaline (NA) in sympathetic nerve fibers, several scientific groups have searched for structures with neuropeptide Y antagonistic properties. Research has mainly focused on various peptide fragments which originate from or are related to the neuropeptide Y sequence. Some non-peptide antagonists have been proposed but they are mostly of low potency and non-selective. Our recent observations that alpha-trinositol (D-myo-inositol 1.2.6-trisphosphate) is an inhibitor of neuropeptide Y effects will hopefully lead to the development of useful non-peptide neuropeptide Y inhibitors. As a novel approach the highly selective approach of down-regulating neuropeptide Y... (More)
Since the discovery of neuropeptide Y which is co-stored and co-operate with noradrenaline (NA) in sympathetic nerve fibers, several scientific groups have searched for structures with neuropeptide Y antagonistic properties. Research has mainly focused on various peptide fragments which originate from or are related to the neuropeptide Y sequence. Some non-peptide antagonists have been proposed but they are mostly of low potency and non-selective. Our recent observations that alpha-trinositol (D-myo-inositol 1.2.6-trisphosphate) is an inhibitor of neuropeptide Y effects will hopefully lead to the development of useful non-peptide neuropeptide Y inhibitors. As a novel approach the highly selective approach of down-regulating neuropeptide Y receptors with antisense oligodeoxynucleotides is also discussed. Neuropeptide Y antagonistic agents would help us to understand the physiological role of neuropeptide Y and may serve as useful medication in circulation disorders. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pharmacology and Toxicology
volume
74
issue
4-5
pages
193 - 201
publisher
Wiley-Blackwell
external identifiers
  • pmid:8090686
  • scopus:0028357934
ISSN
1600-0773
language
English
LU publication?
yes
id
15d6a800-b218-4b3e-9762-5dfcb828c8f1 (old id 1108011)
date added to LUP
2008-07-23 11:18:23
date last changed
2017-01-01 05:15:47
@article{15d6a800-b218-4b3e-9762-5dfcb828c8f1,
  abstract     = {Since the discovery of neuropeptide Y which is co-stored and co-operate with noradrenaline (NA) in sympathetic nerve fibers, several scientific groups have searched for structures with neuropeptide Y antagonistic properties. Research has mainly focused on various peptide fragments which originate from or are related to the neuropeptide Y sequence. Some non-peptide antagonists have been proposed but they are mostly of low potency and non-selective. Our recent observations that alpha-trinositol (D-myo-inositol 1.2.6-trisphosphate) is an inhibitor of neuropeptide Y effects will hopefully lead to the development of useful non-peptide neuropeptide Y inhibitors. As a novel approach the highly selective approach of down-regulating neuropeptide Y receptors with antisense oligodeoxynucleotides is also discussed. Neuropeptide Y antagonistic agents would help us to understand the physiological role of neuropeptide Y and may serve as useful medication in circulation disorders.},
  author       = {Edvinsson, Lars and Erlinge, David and Sun, X Y and Hedner, T},
  issn         = {1600-0773},
  language     = {eng},
  number       = {4-5},
  pages        = {193--201},
  publisher    = {Wiley-Blackwell},
  series       = {Pharmacology and Toxicology},
  title        = {Neuropeptide Y in sympathetic co-transmission: recent advances in the search for neuropeptide Y antagonists},
  volume       = {74},
  year         = {1994},
}