Neuropeptide Y in sympathetic co-transmission: recent advances in the search for neuropeptide Y antagonists
Edvinsson, Lars LU ; Erlinge, David LU
; Sun, X Y
and Hedner, T
(1994)
In Pharmacology and Toxicology
74(4-5).
p.193-201
- Abstract
- Since the discovery of neuropeptide Y which is co-stored and co-operate with noradrenaline (NA) in sympathetic nerve fibers, several scientific groups have searched for structures with neuropeptide Y antagonistic properties. Research has mainly focused on various peptide fragments which originate from or are related to the neuropeptide Y sequence. Some non-peptide antagonists have been proposed but they are mostly of low potency and non-selective. Our recent observations that alpha-trinositol (D-myo-inositol 1.2.6-trisphosphate) is an inhibitor of neuropeptide Y effects will hopefully lead to the development of useful non-peptide neuropeptide Y inhibitors. As a novel approach the highly selective approach of down-regulating neuropeptide Y... (More)
- Since the discovery of neuropeptide Y which is co-stored and co-operate with noradrenaline (NA) in sympathetic nerve fibers, several scientific groups have searched for structures with neuropeptide Y antagonistic properties. Research has mainly focused on various peptide fragments which originate from or are related to the neuropeptide Y sequence. Some non-peptide antagonists have been proposed but they are mostly of low potency and non-selective. Our recent observations that alpha-trinositol (D-myo-inositol 1.2.6-trisphosphate) is an inhibitor of neuropeptide Y effects will hopefully lead to the development of useful non-peptide neuropeptide Y inhibitors. As a novel approach the highly selective approach of down-regulating neuropeptide Y receptors with antisense oligodeoxynucleotides is also discussed. Neuropeptide Y antagonistic agents would help us to understand the physiological role of neuropeptide Y and may serve as useful medication in circulation disorders. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1108011
- author
- Edvinsson, Lars
LU
; Erlinge, David
LU
; Sun, X Y
and Hedner, T
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pharmacology and Toxicology
- volume
- 74
- issue
- 4-5
- pages
- 193 - 201
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:8090686
- scopus:0028357934
- ISSN
- 1600-0773
- language
- English
- LU publication?
- yes
- id
- 15d6a800-b218-4b3e-9762-5dfcb828c8f1 (old id 1108011)
- date added to LUP
- 2016-04-01 12:34:20
- date last changed
- 2021-01-03 05:29:57
@article{15d6a800-b218-4b3e-9762-5dfcb828c8f1,
abstract = {{Since the discovery of neuropeptide Y which is co-stored and co-operate with noradrenaline (NA) in sympathetic nerve fibers, several scientific groups have searched for structures with neuropeptide Y antagonistic properties. Research has mainly focused on various peptide fragments which originate from or are related to the neuropeptide Y sequence. Some non-peptide antagonists have been proposed but they are mostly of low potency and non-selective. Our recent observations that alpha-trinositol (D-myo-inositol 1.2.6-trisphosphate) is an inhibitor of neuropeptide Y effects will hopefully lead to the development of useful non-peptide neuropeptide Y inhibitors. As a novel approach the highly selective approach of down-regulating neuropeptide Y receptors with antisense oligodeoxynucleotides is also discussed. Neuropeptide Y antagonistic agents would help us to understand the physiological role of neuropeptide Y and may serve as useful medication in circulation disorders.}},
author = {{Edvinsson, Lars and Erlinge, David and Sun, X Y and Hedner, T}},
issn = {{1600-0773}},
language = {{eng}},
number = {{4-5}},
pages = {{193--201}},
publisher = {{Wiley-Blackwell}},
series = {{Pharmacology and Toxicology}},
title = {{Neuropeptide Y in sympathetic co-transmission: recent advances in the search for neuropeptide Y antagonists}},
volume = {{74}},
year = {{1994}},
}