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Osseointegration of titanium implants in the tibia. Electron microscopy of biopsies from 4 patients

Serre, Claire M; Boivin, Georges; Obrant, Karl LU and Linder, Lars (1994) In Acta Orthopaedica Scandinavica 65(3). p.323-327
Abstract
We studied the ultrastructure of bone tissue around implants of pure titanium inserted into the tibia in 4 patients with arthrosis or rheumatoid arthritis. Three main appearances of the interface were noted. First, a close contact between titanium and calcified bone with living osteocytes inside the newly-formed bone was observed in all samples. Secondly, a close contact was also seen between the implant and osteoid, the newly formed collagenous matrix being either uncalcified or calcifying. Thirdly, a loose extracellular matrix with fibrillar and nonfibrillar materials was sometimes observed between bone mineral and implant. There was no inflammatory reaction at the interface. We concluded that the titanium implants were osseointegrated,... (More)
We studied the ultrastructure of bone tissue around implants of pure titanium inserted into the tibia in 4 patients with arthrosis or rheumatoid arthritis. Three main appearances of the interface were noted. First, a close contact between titanium and calcified bone with living osteocytes inside the newly-formed bone was observed in all samples. Secondly, a close contact was also seen between the implant and osteoid, the newly formed collagenous matrix being either uncalcified or calcifying. Thirdly, a loose extracellular matrix with fibrillar and nonfibrillar materials was sometimes observed between bone mineral and implant. There was no inflammatory reaction at the interface. We concluded that the titanium implants were osseointegrated, but the calcification of the bone tissue was not complete even after 20 months. However, mineralization of osteoid and living bone cells revealed the presence of an active tissue. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Orthopaedica Scandinavica
volume
65
issue
3
pages
323 - 327
publisher
Taylor & Francis
external identifiers
  • pmid:8042487
  • scopus:0028362336
ISSN
0001-6470
DOI
10.3109/17453679408995462
language
English
LU publication?
yes
id
5f4694c3-caf6-42d6-982c-56a467f12429 (old id 1108115)
date added to LUP
2008-07-23 14:16:16
date last changed
2017-05-28 04:22:54
@article{5f4694c3-caf6-42d6-982c-56a467f12429,
  abstract     = {We studied the ultrastructure of bone tissue around implants of pure titanium inserted into the tibia in 4 patients with arthrosis or rheumatoid arthritis. Three main appearances of the interface were noted. First, a close contact between titanium and calcified bone with living osteocytes inside the newly-formed bone was observed in all samples. Secondly, a close contact was also seen between the implant and osteoid, the newly formed collagenous matrix being either uncalcified or calcifying. Thirdly, a loose extracellular matrix with fibrillar and nonfibrillar materials was sometimes observed between bone mineral and implant. There was no inflammatory reaction at the interface. We concluded that the titanium implants were osseointegrated, but the calcification of the bone tissue was not complete even after 20 months. However, mineralization of osteoid and living bone cells revealed the presence of an active tissue.},
  author       = {Serre, Claire M and Boivin, Georges and Obrant, Karl and Linder, Lars},
  issn         = {0001-6470},
  language     = {eng},
  number       = {3},
  pages        = {323--327},
  publisher    = {Taylor & Francis},
  series       = {Acta Orthopaedica Scandinavica},
  title        = {Osseointegration of titanium implants in the tibia. Electron microscopy of biopsies from 4 patients},
  url          = {http://dx.doi.org/10.3109/17453679408995462},
  volume       = {65},
  year         = {1994},
}