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Functional recovery after brain infarction: plasticity and neural transplantation

Johansson, Barbro LU and Grabowski, Martin LU (1994) In Brain Pathology 4(1). p.85-95
Abstract
In the past, little attention has been given to the role of brain plasticity for the long term functional outcome in experimental stroke although there is substantial evidence for plasticity in other experimental models of neurological disorders. Under clinical conditions, functional improvement occurs in most stroke survivors during the initial months after the ischemic incidence. Recent PET studies in stroke patients, investigated two months or later after stroke, indicate a considerable potential for functional plasticity in the adult human cerebral cortex. Research aimed at the identification of the mechanisms underlying functional recovery should be given high priority, particularly with regard to environmental factors and... (More)
In the past, little attention has been given to the role of brain plasticity for the long term functional outcome in experimental stroke although there is substantial evidence for plasticity in other experimental models of neurological disorders. Under clinical conditions, functional improvement occurs in most stroke survivors during the initial months after the ischemic incidence. Recent PET studies in stroke patients, investigated two months or later after stroke, indicate a considerable potential for functional plasticity in the adult human cerebral cortex. Research aimed at the identification of the mechanisms underlying functional recovery should be given high priority, particularly with regard to environmental factors and pharmacological interventions. Pilot experiments of environmental enrichment significantly improved the functional outcome of laboratory animals after brain infarction. Fetal neocortical tissue grafted into the infarcted area in adult rats received afferent fibres from the intact brain and responded to contralateral sensory stimulation with increased metabolic activity, indicating functional integration between neocortical grafts and host afferent systems. However, reciprocal connections from the graft to the host tissue were rare, and it remains to be shown whether grafting will be able to restore the complex cortical organization of the infarcted tissue. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Brain Pathology
volume
4
issue
1
pages
85 - 95
publisher
Wiley-Blackwell
external identifiers
  • pmid:7912982
  • scopus:0028316609
ISSN
1750-3639
DOI
10.1111/j.1750-3639.1994.tb00814.x
language
English
LU publication?
yes
id
8c5e7f3b-e6b0-4112-9cb2-4fee7eff4a28 (old id 1108218)
date added to LUP
2008-07-23 15:44:52
date last changed
2017-08-27 05:09:45
@article{8c5e7f3b-e6b0-4112-9cb2-4fee7eff4a28,
  abstract     = {In the past, little attention has been given to the role of brain plasticity for the long term functional outcome in experimental stroke although there is substantial evidence for plasticity in other experimental models of neurological disorders. Under clinical conditions, functional improvement occurs in most stroke survivors during the initial months after the ischemic incidence. Recent PET studies in stroke patients, investigated two months or later after stroke, indicate a considerable potential for functional plasticity in the adult human cerebral cortex. Research aimed at the identification of the mechanisms underlying functional recovery should be given high priority, particularly with regard to environmental factors and pharmacological interventions. Pilot experiments of environmental enrichment significantly improved the functional outcome of laboratory animals after brain infarction. Fetal neocortical tissue grafted into the infarcted area in adult rats received afferent fibres from the intact brain and responded to contralateral sensory stimulation with increased metabolic activity, indicating functional integration between neocortical grafts and host afferent systems. However, reciprocal connections from the graft to the host tissue were rare, and it remains to be shown whether grafting will be able to restore the complex cortical organization of the infarcted tissue.},
  author       = {Johansson, Barbro and Grabowski, Martin},
  issn         = {1750-3639},
  language     = {eng},
  number       = {1},
  pages        = {85--95},
  publisher    = {Wiley-Blackwell},
  series       = {Brain Pathology},
  title        = {Functional recovery after brain infarction: plasticity and neural transplantation},
  url          = {http://dx.doi.org/10.1111/j.1750-3639.1994.tb00814.x},
  volume       = {4},
  year         = {1994},
}