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Pathogenesis of vascular dementia: the possible role of hypertension

Johansson, Barbro LU (1994) In Dementia 5(3-4). p.174-176
Abstract
In spite of the fact that hypertension is the main risk factor for cerebrovascular disease, retrospective studies have not given a clear answer concerning the role of hypertension in vascular dementia. Hypertension predisposes to intracerebral and extracerebral arterial alterations which may cause cerebrovascular events by a number of mechanisms. In addition to the established association between hypertension and stroke, the role of hypertension for silent white matter hyperintensities (WMHIs) observed on magnetic resonance imaging is debated. Data are presented indicating that WMHIs are rare below the age of 55 in normotensive individuals but are not infrequent when the blood pressure is moderately or markedly increased. It is proposed... (More)
In spite of the fact that hypertension is the main risk factor for cerebrovascular disease, retrospective studies have not given a clear answer concerning the role of hypertension in vascular dementia. Hypertension predisposes to intracerebral and extracerebral arterial alterations which may cause cerebrovascular events by a number of mechanisms. In addition to the established association between hypertension and stroke, the role of hypertension for silent white matter hyperintensities (WMHIs) observed on magnetic resonance imaging is debated. Data are presented indicating that WMHIs are rare below the age of 55 in normotensive individuals but are not infrequent when the blood pressure is moderately or markedly increased. It is proposed that the possible role of hypertension in vascular dementia should be evaluated in prospective studies of hypertensive populations. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hypertensive vascular disease, Hypertension, Vascular dementia, Magnetic resonance imaging
in
Dementia
volume
5
issue
3-4
pages
174 - 176
publisher
Karger
external identifiers
  • pmid:8087174
  • scopus:0028287502
ISSN
1741-2684
DOI
10.1159/000106717
language
English
LU publication?
yes
id
e5050725-83b3-40e2-af8c-dba6c62c3772 (old id 1108250)
date added to LUP
2008-07-23 16:09:30
date last changed
2017-01-01 07:24:40
@article{e5050725-83b3-40e2-af8c-dba6c62c3772,
  abstract     = {In spite of the fact that hypertension is the main risk factor for cerebrovascular disease, retrospective studies have not given a clear answer concerning the role of hypertension in vascular dementia. Hypertension predisposes to intracerebral and extracerebral arterial alterations which may cause cerebrovascular events by a number of mechanisms. In addition to the established association between hypertension and stroke, the role of hypertension for silent white matter hyperintensities (WMHIs) observed on magnetic resonance imaging is debated. Data are presented indicating that WMHIs are rare below the age of 55 in normotensive individuals but are not infrequent when the blood pressure is moderately or markedly increased. It is proposed that the possible role of hypertension in vascular dementia should be evaluated in prospective studies of hypertensive populations.},
  author       = {Johansson, Barbro},
  issn         = {1741-2684},
  keyword      = {Hypertensive vascular disease,Hypertension,Vascular dementia,Magnetic resonance imaging},
  language     = {eng},
  number       = {3-4},
  pages        = {174--176},
  publisher    = {Karger},
  series       = {Dementia},
  title        = {Pathogenesis of vascular dementia: the possible role of hypertension},
  url          = {http://dx.doi.org/10.1159/000106717},
  volume       = {5},
  year         = {1994},
}