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IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis.

Svensson, Lars LU ; Nandakumar, Kutty Selva; Johansson, Åsa LU ; Jansson, Liselotte LU and Holmdahl, Rikard LU (2002) In European Journal of Immunology 32(10). p.2944-2953
Abstract
Rheumatoid arthritis as well as collagen-induced arthritis (CIA) is thought to involve T cell autoimmunity of the Th1 type and the Th2 cytokine IL-4 has been proposed to play a suppressive role. To exclude a possible skewing role of the mycobacteria used in the complete Freund's adjuvant (CFA) we induced CIA with type II collagen (CII) in incomplete Freund's adjuvant (IFA). Ourresults show that IL-4 deficiency leads to a lesser susceptibility to arthritis and lower B and T cell responses if induced with CII/IFA but not if induced with CII/CFA. In addition, IL-4-deficientmice were less susceptible to arthritis induced with monoclonal anti-CII antibodies. However, mice immunized with CII/IFA later developed a chronic relapsing disease, which... (More)
Rheumatoid arthritis as well as collagen-induced arthritis (CIA) is thought to involve T cell autoimmunity of the Th1 type and the Th2 cytokine IL-4 has been proposed to play a suppressive role. To exclude a possible skewing role of the mycobacteria used in the complete Freund's adjuvant (CFA) we induced CIA with type II collagen (CII) in incomplete Freund's adjuvant (IFA). Ourresults show that IL-4 deficiency leads to a lesser susceptibility to arthritis and lower B and T cell responses if induced with CII/IFA but not if induced with CII/CFA. In addition, IL-4-deficientmice were less susceptible to arthritis induced with monoclonal anti-CII antibodies. However, mice immunized with CII/IFA later developed a chronic relapsing disease, which was promoted by IL-4 deficiency. We conclude that IL-4 plays different roles depending on the type of adjuvant used and the phase (acute or chronic) of the clinical disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Immunology
volume
32
issue
10
pages
2944 - 2953
publisher
John Wiley & Sons
external identifiers
  • pmid:12355448
  • wos:000178746600027
  • scopus:0036774695
ISSN
1521-4141
DOI
10.1002/1521-4141(2002010)32:10<2944::AID-IMMU2944>3.0.CO;2-4
language
English
LU publication?
yes
id
7a96fce0-8f51-411a-80c0-a928c51ed62b (old id 110833)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12355448&dopt=Abstract
date added to LUP
2007-07-19 15:23:01
date last changed
2017-01-01 04:21:43
@article{7a96fce0-8f51-411a-80c0-a928c51ed62b,
  abstract     = {Rheumatoid arthritis as well as collagen-induced arthritis (CIA) is thought to involve T cell autoimmunity of the Th1 type and the Th2 cytokine IL-4 has been proposed to play a suppressive role. To exclude a possible skewing role of the mycobacteria used in the complete Freund's adjuvant (CFA) we induced CIA with type II collagen (CII) in incomplete Freund's adjuvant (IFA). Ourresults show that IL-4 deficiency leads to a lesser susceptibility to arthritis and lower B and T cell responses if induced with CII/IFA but not if induced with CII/CFA. In addition, IL-4-deficientmice were less susceptible to arthritis induced with monoclonal anti-CII antibodies. However, mice immunized with CII/IFA later developed a chronic relapsing disease, which was promoted by IL-4 deficiency. We conclude that IL-4 plays different roles depending on the type of adjuvant used and the phase (acute or chronic) of the clinical disease.},
  author       = {Svensson, Lars and Nandakumar, Kutty Selva and Johansson, Åsa and Jansson, Liselotte and Holmdahl, Rikard},
  issn         = {1521-4141},
  language     = {eng},
  number       = {10},
  pages        = {2944--2953},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Immunology},
  title        = {IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis.},
  url          = {http://dx.doi.org/10.1002/1521-4141(2002010)32:10<2944::AID-IMMU2944>3.0.CO;2-4},
  volume       = {32},
  year         = {2002},
}