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IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis.

Svensson, Lars LU ; Nandakumar, Kutty Selva ; Johansson, Åsa LU ; Jansson, Liselotte LU and Holmdahl, Rikard LU (2002) In European Journal of Immunology 32(10). p.2944-2953
Abstract
Rheumatoid arthritis as well as collagen-induced arthritis (CIA) is thought to involve T cell autoimmunity of the Th1 type and the Th2 cytokine IL-4 has been proposed to play a suppressive role. To exclude a possible skewing role of the mycobacteria used in the complete Freund's adjuvant (CFA) we induced CIA with type II collagen (CII) in incomplete Freund's adjuvant (IFA). Ourresults show that IL-4 deficiency leads to a lesser susceptibility to arthritis and lower B and T cell responses if induced with CII/IFA but not if induced with CII/CFA. In addition, IL-4-deficientmice were less susceptible to arthritis induced with monoclonal anti-CII antibodies. However, mice immunized with CII/IFA later developed a chronic relapsing disease, which... (More)
Rheumatoid arthritis as well as collagen-induced arthritis (CIA) is thought to involve T cell autoimmunity of the Th1 type and the Th2 cytokine IL-4 has been proposed to play a suppressive role. To exclude a possible skewing role of the mycobacteria used in the complete Freund's adjuvant (CFA) we induced CIA with type II collagen (CII) in incomplete Freund's adjuvant (IFA). Ourresults show that IL-4 deficiency leads to a lesser susceptibility to arthritis and lower B and T cell responses if induced with CII/IFA but not if induced with CII/CFA. In addition, IL-4-deficientmice were less susceptible to arthritis induced with monoclonal anti-CII antibodies. However, mice immunized with CII/IFA later developed a chronic relapsing disease, which was promoted by IL-4 deficiency. We conclude that IL-4 plays different roles depending on the type of adjuvant used and the phase (acute or chronic) of the clinical disease. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Immunology
volume
32
issue
10
pages
2944 - 2953
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:12355448
  • wos:000178746600027
  • scopus:0036774695
ISSN
1521-4141
DOI
10.1002/1521-4141(2002010)32:10<2944::AID-IMMU2944>3.0.CO;2-4
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
id
7a96fce0-8f51-411a-80c0-a928c51ed62b (old id 110833)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12355448&dopt=Abstract
date added to LUP
2016-04-01 11:36:15
date last changed
2022-01-26 07:31:51
@article{7a96fce0-8f51-411a-80c0-a928c51ed62b,
  abstract     = {{Rheumatoid arthritis as well as collagen-induced arthritis (CIA) is thought to involve T cell autoimmunity of the Th1 type and the Th2 cytokine IL-4 has been proposed to play a suppressive role. To exclude a possible skewing role of the mycobacteria used in the complete Freund's adjuvant (CFA) we induced CIA with type II collagen (CII) in incomplete Freund's adjuvant (IFA). Ourresults show that IL-4 deficiency leads to a lesser susceptibility to arthritis and lower B and T cell responses if induced with CII/IFA but not if induced with CII/CFA. In addition, IL-4-deficientmice were less susceptible to arthritis induced with monoclonal anti-CII antibodies. However, mice immunized with CII/IFA later developed a chronic relapsing disease, which was promoted by IL-4 deficiency. We conclude that IL-4 plays different roles depending on the type of adjuvant used and the phase (acute or chronic) of the clinical disease.}},
  author       = {{Svensson, Lars and Nandakumar, Kutty Selva and Johansson, Åsa and Jansson, Liselotte and Holmdahl, Rikard}},
  issn         = {{1521-4141}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{2944--2953}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{European Journal of Immunology}},
  title        = {{IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis.}},
  url          = {{http://dx.doi.org/10.1002/1521-4141(2002010)32:10<2944::AID-IMMU2944>3.0.CO;2-4}},
  doi          = {{10.1002/1521-4141(2002010)32:10<2944::AID-IMMU2944>3.0.CO;2-4}},
  volume       = {{32}},
  year         = {{2002}},
}