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Dynorphin B is present in sensory and parasympathetic nerves innervating pial arteries

Hardebo, Jan Erik LU ; Suzuki, Norihiro and Owman, Christer LU (1994) In Journal of the Autonomic Nervous System 47(3). p.171-176
Abstract
Dynorphin B (dyn B) in trigeminal ganglion cells and in perivascular nerve fibers in pial arteries was demonstrated in rat, guinea-pig, and monkey by immunohistochemistry. The pathway from the trigeminal ganglion, which runs via the nasociliary nerve and ethmoidal foramen to the pial arteries, was shown in rat by retrograde tracer technique and nerve section. In the guinea-pig the peptide was demonstrated to coexist with substance P and calcitonin gene-related peptide in neurons of the trigeminal ganglion and pial nerve fibers, i.e., it was present in cerebrovascular sensory nerves with primarily nociceptive function. Another finding in guinea-pig was a coexistence of dyn B with vasoactive intestinal polypeptide in the pial nerve fibers... (More)
Dynorphin B (dyn B) in trigeminal ganglion cells and in perivascular nerve fibers in pial arteries was demonstrated in rat, guinea-pig, and monkey by immunohistochemistry. The pathway from the trigeminal ganglion, which runs via the nasociliary nerve and ethmoidal foramen to the pial arteries, was shown in rat by retrograde tracer technique and nerve section. In the guinea-pig the peptide was demonstrated to coexist with substance P and calcitonin gene-related peptide in neurons of the trigeminal ganglion and pial nerve fibers, i.e., it was present in cerebrovascular sensory nerves with primarily nociceptive function. Another finding in guinea-pig was a coexistence of dyn B with vasoactive intestinal polypeptide in the pial nerve fibers and neurons of the sphenopalatine ganglion, indicating a presence also in parasympathetic nerves to the cerebral vessels. No vasomotor effect of dyn B could be detected in isolated segments of rat pial arteries, which rules out a direct postsynaptic effect on vascular tone. The peptide did not display a prejunctional modulatory action on the adrenergic nerves present in the vessels. The function of dyn B in the cerebrovascular nerves is discussed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Sensory nerve fiber, Parasympathetic nerve, Trigeminal ganglion, Cranial parasympathetic ganglia, Dynorphin, Immunohistochemistry
in
Journal of the Autonomic Nervous System
volume
47
issue
3
pages
171 - 176
publisher
Elsevier
external identifiers
  • pmid:7516945
  • scopus:0028201289
ISSN
0165-1838
DOI
10.1016/0165-1838(94)90178-3
language
English
LU publication?
yes
id
65a938ba-b86a-4cb3-92ed-266ad42a25f6 (old id 1108334)
date added to LUP
2008-07-23 17:19:55
date last changed
2017-01-01 06:44:15
@article{65a938ba-b86a-4cb3-92ed-266ad42a25f6,
  abstract     = {Dynorphin B (dyn B) in trigeminal ganglion cells and in perivascular nerve fibers in pial arteries was demonstrated in rat, guinea-pig, and monkey by immunohistochemistry. The pathway from the trigeminal ganglion, which runs via the nasociliary nerve and ethmoidal foramen to the pial arteries, was shown in rat by retrograde tracer technique and nerve section. In the guinea-pig the peptide was demonstrated to coexist with substance P and calcitonin gene-related peptide in neurons of the trigeminal ganglion and pial nerve fibers, i.e., it was present in cerebrovascular sensory nerves with primarily nociceptive function. Another finding in guinea-pig was a coexistence of dyn B with vasoactive intestinal polypeptide in the pial nerve fibers and neurons of the sphenopalatine ganglion, indicating a presence also in parasympathetic nerves to the cerebral vessels. No vasomotor effect of dyn B could be detected in isolated segments of rat pial arteries, which rules out a direct postsynaptic effect on vascular tone. The peptide did not display a prejunctional modulatory action on the adrenergic nerves present in the vessels. The function of dyn B in the cerebrovascular nerves is discussed.},
  author       = {Hardebo, Jan Erik and Suzuki, Norihiro and Owman, Christer},
  issn         = {0165-1838},
  keyword      = {Sensory nerve fiber,Parasympathetic nerve,Trigeminal ganglion,Cranial parasympathetic ganglia,Dynorphin,Immunohistochemistry},
  language     = {eng},
  number       = {3},
  pages        = {171--176},
  publisher    = {Elsevier},
  series       = {Journal of the Autonomic Nervous System},
  title        = {Dynorphin B is present in sensory and parasympathetic nerves innervating pial arteries},
  url          = {http://dx.doi.org/10.1016/0165-1838(94)90178-3},
  volume       = {47},
  year         = {1994},
}