Advanced

Prevention of joint destruction in antigen-induced arthritis

Wollheim, Frank LU ; Telhag, Hans; Henricsson, Anders and Geborek, Pierre LU (1994) In Clinical Immunology and Immunopathology 70(1). p.19-21
Abstract
In rheumatoid arthritis (RA) erosive joint changes are the dominating cause of chronic disability. In a cohort of patients with RA followed from early stages of the disease, we have observed a much larger prevalence of destructions in hips than in knee joints. The latter were frequently injected with triamcinolone hexacetonide in contrast to the former. In order to elucidate a possible role of local glucocorticoids we studied the antigen-induced arthritis model of Dumonde and Glynn in rabbits which, untreated, caused advanced joint destruction in 3/5 animals, whereas 0/14 animals receiving 3 injections of triamcinolone hexacetonide developed no such changes. The treatment was effective when started up to 2 weeks after induction of the... (More)
In rheumatoid arthritis (RA) erosive joint changes are the dominating cause of chronic disability. In a cohort of patients with RA followed from early stages of the disease, we have observed a much larger prevalence of destructions in hips than in knee joints. The latter were frequently injected with triamcinolone hexacetonide in contrast to the former. In order to elucidate a possible role of local glucocorticoids we studied the antigen-induced arthritis model of Dumonde and Glynn in rabbits which, untreated, caused advanced joint destruction in 3/5 animals, whereas 0/14 animals receiving 3 injections of triamcinolone hexacetonide developed no such changes. The treatment was effective when started up to 2 weeks after induction of the arthritis. It is suggested that locally administered glucocorticoids may prevent or delay large joint destruction in RA. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Immunology and Immunopathology
volume
70
issue
1
pages
19 - 21
publisher
Academic Press
external identifiers
  • pmid:8261663
  • scopus:0027976617
ISSN
1090-2341
DOI
10.1006/clin.1994.1004
language
English
LU publication?
yes
id
f38c9e35-c28e-4e6f-8d7f-917abf53be9b (old id 1108370)
date added to LUP
2008-07-23 17:48:14
date last changed
2017-01-01 05:04:23
@article{f38c9e35-c28e-4e6f-8d7f-917abf53be9b,
  abstract     = {In rheumatoid arthritis (RA) erosive joint changes are the dominating cause of chronic disability. In a cohort of patients with RA followed from early stages of the disease, we have observed a much larger prevalence of destructions in hips than in knee joints. The latter were frequently injected with triamcinolone hexacetonide in contrast to the former. In order to elucidate a possible role of local glucocorticoids we studied the antigen-induced arthritis model of Dumonde and Glynn in rabbits which, untreated, caused advanced joint destruction in 3/5 animals, whereas 0/14 animals receiving 3 injections of triamcinolone hexacetonide developed no such changes. The treatment was effective when started up to 2 weeks after induction of the arthritis. It is suggested that locally administered glucocorticoids may prevent or delay large joint destruction in RA.},
  author       = {Wollheim, Frank and Telhag, Hans and Henricsson, Anders and Geborek, Pierre},
  issn         = {1090-2341},
  language     = {eng},
  number       = {1},
  pages        = {19--21},
  publisher    = {Academic Press},
  series       = {Clinical Immunology and Immunopathology},
  title        = {Prevention of joint destruction in antigen-induced arthritis},
  url          = {http://dx.doi.org/10.1006/clin.1994.1004},
  volume       = {70},
  year         = {1994},
}