Prevention of joint destruction in antigen-induced arthritis
(1994) In Clinical Immunology and Immunopathology 70(1). p.19-21- Abstract
- In rheumatoid arthritis (RA) erosive joint changes are the dominating cause of chronic disability. In a cohort of patients with RA followed from early stages of the disease, we have observed a much larger prevalence of destructions in hips than in knee joints. The latter were frequently injected with triamcinolone hexacetonide in contrast to the former. In order to elucidate a possible role of local glucocorticoids we studied the antigen-induced arthritis model of Dumonde and Glynn in rabbits which, untreated, caused advanced joint destruction in 3/5 animals, whereas 0/14 animals receiving 3 injections of triamcinolone hexacetonide developed no such changes. The treatment was effective when started up to 2 weeks after induction of the... (More)
- In rheumatoid arthritis (RA) erosive joint changes are the dominating cause of chronic disability. In a cohort of patients with RA followed from early stages of the disease, we have observed a much larger prevalence of destructions in hips than in knee joints. The latter were frequently injected with triamcinolone hexacetonide in contrast to the former. In order to elucidate a possible role of local glucocorticoids we studied the antigen-induced arthritis model of Dumonde and Glynn in rabbits which, untreated, caused advanced joint destruction in 3/5 animals, whereas 0/14 animals receiving 3 injections of triamcinolone hexacetonide developed no such changes. The treatment was effective when started up to 2 weeks after induction of the arthritis. It is suggested that locally administered glucocorticoids may prevent or delay large joint destruction in RA. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1108370
- author
- Wollheim, Frank LU ; Telhag, Hans ; Henricsson, Anders and Geborek, Pierre LU
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Immunology and Immunopathology
- volume
- 70
- issue
- 1
- pages
- 19 - 21
- publisher
- Elsevier
- external identifiers
-
- pmid:8261663
- scopus:0027976617
- ISSN
- 1090-2341
- DOI
- 10.1006/clin.1994.1004
- language
- English
- LU publication?
- yes
- id
- f38c9e35-c28e-4e6f-8d7f-917abf53be9b (old id 1108370)
- date added to LUP
- 2016-04-01 12:21:26
- date last changed
- 2021-01-03 04:36:13
@article{f38c9e35-c28e-4e6f-8d7f-917abf53be9b,
abstract = {{In rheumatoid arthritis (RA) erosive joint changes are the dominating cause of chronic disability. In a cohort of patients with RA followed from early stages of the disease, we have observed a much larger prevalence of destructions in hips than in knee joints. The latter were frequently injected with triamcinolone hexacetonide in contrast to the former. In order to elucidate a possible role of local glucocorticoids we studied the antigen-induced arthritis model of Dumonde and Glynn in rabbits which, untreated, caused advanced joint destruction in 3/5 animals, whereas 0/14 animals receiving 3 injections of triamcinolone hexacetonide developed no such changes. The treatment was effective when started up to 2 weeks after induction of the arthritis. It is suggested that locally administered glucocorticoids may prevent or delay large joint destruction in RA.}},
author = {{Wollheim, Frank and Telhag, Hans and Henricsson, Anders and Geborek, Pierre}},
issn = {{1090-2341}},
language = {{eng}},
number = {{1}},
pages = {{19--21}},
publisher = {{Elsevier}},
series = {{Clinical Immunology and Immunopathology}},
title = {{Prevention of joint destruction in antigen-induced arthritis}},
url = {{http://dx.doi.org/10.1006/clin.1994.1004}},
doi = {{10.1006/clin.1994.1004}},
volume = {{70}},
year = {{1994}},
}