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Increase in insulin-like growth factor I in hypertrophying smooth muscle

Chen, Y; Bornfeldt, K E; Arner, Anders LU ; Jennische, E; Malmqvist, Ulf LU ; Uvelius, Bengt LU and Arnqvist, H J (1994) In American Journal of Physiology 266(2 Pt 1). p.224-229
Abstract
The present study focuses on the role of the insulin-like growth factor (IGF) system in the development of smooth muscle hypertrophy. Hypertrophy was initiated by partial ligation of portal vein or urethra in female Sprague-Dawley rats weighing approximately 220 g. Levels of mRNA were analyzed by solution hybridization. Seven days after ligation, the wet weight of the portal vein was increased about threefold and the concentration of IGF-I mRNA was increased fourfold. The bladder wet weight was increased twofold 3 days after ligation and fourfold 10 days after ligation. IGF-I mRNA in the bladder was elevated 3-fold after 3 days and 2.5-fold after 10 days, whereas IGF binding protein 2 mRNA was increased approximately 2-fold after 3 days... (More)
The present study focuses on the role of the insulin-like growth factor (IGF) system in the development of smooth muscle hypertrophy. Hypertrophy was initiated by partial ligation of portal vein or urethra in female Sprague-Dawley rats weighing approximately 220 g. Levels of mRNA were analyzed by solution hybridization. Seven days after ligation, the wet weight of the portal vein was increased about threefold and the concentration of IGF-I mRNA was increased fourfold. The bladder wet weight was increased twofold 3 days after ligation and fourfold 10 days after ligation. IGF-I mRNA in the bladder was elevated 3-fold after 3 days and 2.5-fold after 10 days, whereas IGF binding protein 2 mRNA was increased approximately 2-fold after 3 days and 5-fold after 10 days. IGF-I receptor mRNA in the hypertrophying bladder remained unchanged. Increased levels of IGF-I were demonstrated with immunohistochemistry in both hypertrophying portal vein and urinary bladder. The results show a specific increase in IGF-I mRNA as well as an increased IGF-I immunoreactivity during hypertrophy of smooth muscle, which suggests that the local IGF-system may play a role in smooth muscle hypertrophy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Physiology
volume
266
issue
2 Pt 1
pages
224 - 229
publisher
American Pysiological Society
external identifiers
  • pmid:7511339
  • scopus:0028718693
ISSN
0002-9513
language
English
LU publication?
yes
id
48c852f4-7452-4837-a0c2-e28a87eaf0be (old id 1108528)
alternative location
http://ajpendo.physiology.org/cgi/reprint/266/2/E224
date added to LUP
2008-07-24 11:48:29
date last changed
2017-02-22 11:44:30
@article{48c852f4-7452-4837-a0c2-e28a87eaf0be,
  abstract     = {The present study focuses on the role of the insulin-like growth factor (IGF) system in the development of smooth muscle hypertrophy. Hypertrophy was initiated by partial ligation of portal vein or urethra in female Sprague-Dawley rats weighing approximately 220 g. Levels of mRNA were analyzed by solution hybridization. Seven days after ligation, the wet weight of the portal vein was increased about threefold and the concentration of IGF-I mRNA was increased fourfold. The bladder wet weight was increased twofold 3 days after ligation and fourfold 10 days after ligation. IGF-I mRNA in the bladder was elevated 3-fold after 3 days and 2.5-fold after 10 days, whereas IGF binding protein 2 mRNA was increased approximately 2-fold after 3 days and 5-fold after 10 days. IGF-I receptor mRNA in the hypertrophying bladder remained unchanged. Increased levels of IGF-I were demonstrated with immunohistochemistry in both hypertrophying portal vein and urinary bladder. The results show a specific increase in IGF-I mRNA as well as an increased IGF-I immunoreactivity during hypertrophy of smooth muscle, which suggests that the local IGF-system may play a role in smooth muscle hypertrophy.},
  author       = {Chen, Y and Bornfeldt, K E and Arner, Anders and Jennische, E and Malmqvist, Ulf and Uvelius, Bengt and Arnqvist, H J},
  issn         = {0002-9513},
  language     = {eng},
  number       = {2 Pt 1},
  pages        = {224--229},
  publisher    = {American Pysiological Society},
  series       = {American Journal of Physiology},
  title        = {Increase in insulin-like growth factor I in hypertrophying smooth muscle},
  volume       = {266},
  year         = {1994},
}