Nitric oxide gives maximal response after coronary artery bypass surgery
(1994) In Journal of Cardiothoracic and Vascular Anesthesia 8(2). p.182-187- Abstract
- The dose-response to inhalation of nitric oxide (NO) after coronary artery bypass surgery was studied in seven patients with normal preoperative lung function and chest radiograms. During postoperative controlled ventilation with PEEP 5 and 10 cmH2O, the patients inhaled NO in concentrations of 2 to 25 ppm, in random order, for 6 to 10 minutes. Hemodynamic and oximetric data were analyzed before, 5 minutes after start of the NO inhalation, and 5 minutes after the cessation. The response was the same at all concentrations; mean pulmonary artery pressure decreased by 11 +/- 1% (P < 0.05) and pulmonary vascular resistance decreased by 22 +/- 2% (P < 0.05). Systemic hemodynamics did not change, but oximetric parameters tended to improve.... (More)
- The dose-response to inhalation of nitric oxide (NO) after coronary artery bypass surgery was studied in seven patients with normal preoperative lung function and chest radiograms. During postoperative controlled ventilation with PEEP 5 and 10 cmH2O, the patients inhaled NO in concentrations of 2 to 25 ppm, in random order, for 6 to 10 minutes. Hemodynamic and oximetric data were analyzed before, 5 minutes after start of the NO inhalation, and 5 minutes after the cessation. The response was the same at all concentrations; mean pulmonary artery pressure decreased by 11 +/- 1% (P < 0.05) and pulmonary vascular resistance decreased by 22 +/- 2% (P < 0.05). Systemic hemodynamics did not change, but oximetric parameters tended to improve. Changes in PEEP did not affect the response. It is concluded that, in patients who have undergone coronary artery bypass grafting, inhalation of 2 to 25 ppm NO causes a dose-independent decrease in pulmonary artery pressure and pulmonary vascular resistance. In order to investigate the dose-response curve, concentrations lower than 2 ppm of NO must be used. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1108591
- author
- Lindberg, Lars LU ; Larsson, Anders ; Steen, Stig LU ; Olsson, Sven-Gunnar and Nordstrom, Lars
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- coronary artery bypass, vascular resistance, nitric oxide
- in
- Journal of Cardiothoracic and Vascular Anesthesia
- volume
- 8
- issue
- 2
- pages
- 182 - 187
- publisher
- Elsevier
- external identifiers
-
- pmid:8204811
- scopus:0028230556
- ISSN
- 1532-8422
- DOI
- 10.1016/1053-0770(94)90059-0
- language
- English
- LU publication?
- yes
- id
- ca005673-913b-4659-abad-7febde3b9b12 (old id 1108591)
- date added to LUP
- 2016-04-01 12:25:19
- date last changed
- 2021-08-29 03:18:15
@article{ca005673-913b-4659-abad-7febde3b9b12, abstract = {{The dose-response to inhalation of nitric oxide (NO) after coronary artery bypass surgery was studied in seven patients with normal preoperative lung function and chest radiograms. During postoperative controlled ventilation with PEEP 5 and 10 cmH2O, the patients inhaled NO in concentrations of 2 to 25 ppm, in random order, for 6 to 10 minutes. Hemodynamic and oximetric data were analyzed before, 5 minutes after start of the NO inhalation, and 5 minutes after the cessation. The response was the same at all concentrations; mean pulmonary artery pressure decreased by 11 +/- 1% (P < 0.05) and pulmonary vascular resistance decreased by 22 +/- 2% (P < 0.05). Systemic hemodynamics did not change, but oximetric parameters tended to improve. Changes in PEEP did not affect the response. It is concluded that, in patients who have undergone coronary artery bypass grafting, inhalation of 2 to 25 ppm NO causes a dose-independent decrease in pulmonary artery pressure and pulmonary vascular resistance. In order to investigate the dose-response curve, concentrations lower than 2 ppm of NO must be used.}}, author = {{Lindberg, Lars and Larsson, Anders and Steen, Stig and Olsson, Sven-Gunnar and Nordstrom, Lars}}, issn = {{1532-8422}}, keywords = {{coronary artery bypass; vascular resistance; nitric oxide}}, language = {{eng}}, number = {{2}}, pages = {{182--187}}, publisher = {{Elsevier}}, series = {{Journal of Cardiothoracic and Vascular Anesthesia}}, title = {{Nitric oxide gives maximal response after coronary artery bypass surgery}}, url = {{http://dx.doi.org/10.1016/1053-0770(94)90059-0}}, doi = {{10.1016/1053-0770(94)90059-0}}, volume = {{8}}, year = {{1994}}, }