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Nitric oxide gives maximal response after coronary artery bypass surgery

Lindberg, Lars LU ; Larsson, Anders; Steen, Stig LU ; Olsson, Sven-Gunnar and Nordstrom, Lars (1994) In Journal of Cardiothoracic and Vascular Anesthesia 8(2). p.182-187
Abstract
The dose-response to inhalation of nitric oxide (NO) after coronary artery bypass surgery was studied in seven patients with normal preoperative lung function and chest radiograms. During postoperative controlled ventilation with PEEP 5 and 10 cmH2O, the patients inhaled NO in concentrations of 2 to 25 ppm, in random order, for 6 to 10 minutes. Hemodynamic and oximetric data were analyzed before, 5 minutes after start of the NO inhalation, and 5 minutes after the cessation. The response was the same at all concentrations; mean pulmonary artery pressure decreased by 11 +/- 1% (P < 0.05) and pulmonary vascular resistance decreased by 22 +/- 2% (P < 0.05). Systemic hemodynamics did not change, but oximetric parameters tended to improve.... (More)
The dose-response to inhalation of nitric oxide (NO) after coronary artery bypass surgery was studied in seven patients with normal preoperative lung function and chest radiograms. During postoperative controlled ventilation with PEEP 5 and 10 cmH2O, the patients inhaled NO in concentrations of 2 to 25 ppm, in random order, for 6 to 10 minutes. Hemodynamic and oximetric data were analyzed before, 5 minutes after start of the NO inhalation, and 5 minutes after the cessation. The response was the same at all concentrations; mean pulmonary artery pressure decreased by 11 +/- 1% (P < 0.05) and pulmonary vascular resistance decreased by 22 +/- 2% (P < 0.05). Systemic hemodynamics did not change, but oximetric parameters tended to improve. Changes in PEEP did not affect the response. It is concluded that, in patients who have undergone coronary artery bypass grafting, inhalation of 2 to 25 ppm NO causes a dose-independent decrease in pulmonary artery pressure and pulmonary vascular resistance. In order to investigate the dose-response curve, concentrations lower than 2 ppm of NO must be used. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
coronary artery bypass, vascular resistance, nitric oxide
in
Journal of Cardiothoracic and Vascular Anesthesia
volume
8
issue
2
pages
182 - 187
publisher
W B Saunders
external identifiers
  • pmid:8204811
  • scopus:0028230556
ISSN
1532-8422
DOI
10.1016/1053-0770(94)90059-0
language
English
LU publication?
yes
id
ca005673-913b-4659-abad-7febde3b9b12 (old id 1108591)
date added to LUP
2008-07-24 13:38:14
date last changed
2017-01-01 05:07:47
@article{ca005673-913b-4659-abad-7febde3b9b12,
  abstract     = {The dose-response to inhalation of nitric oxide (NO) after coronary artery bypass surgery was studied in seven patients with normal preoperative lung function and chest radiograms. During postoperative controlled ventilation with PEEP 5 and 10 cmH2O, the patients inhaled NO in concentrations of 2 to 25 ppm, in random order, for 6 to 10 minutes. Hemodynamic and oximetric data were analyzed before, 5 minutes after start of the NO inhalation, and 5 minutes after the cessation. The response was the same at all concentrations; mean pulmonary artery pressure decreased by 11 +/- 1% (P &lt; 0.05) and pulmonary vascular resistance decreased by 22 +/- 2% (P &lt; 0.05). Systemic hemodynamics did not change, but oximetric parameters tended to improve. Changes in PEEP did not affect the response. It is concluded that, in patients who have undergone coronary artery bypass grafting, inhalation of 2 to 25 ppm NO causes a dose-independent decrease in pulmonary artery pressure and pulmonary vascular resistance. In order to investigate the dose-response curve, concentrations lower than 2 ppm of NO must be used.},
  author       = {Lindberg, Lars and Larsson, Anders and Steen, Stig and Olsson, Sven-Gunnar and Nordstrom, Lars},
  issn         = {1532-8422},
  keyword      = {coronary artery bypass,vascular resistance,nitric oxide},
  language     = {eng},
  number       = {2},
  pages        = {182--187},
  publisher    = {W B Saunders},
  series       = {Journal of Cardiothoracic and Vascular Anesthesia},
  title        = {Nitric oxide gives maximal response after coronary artery bypass surgery},
  url          = {http://dx.doi.org/10.1016/1053-0770(94)90059-0},
  volume       = {8},
  year         = {1994},
}