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Effects of hypothermia with and without buffering in hypercapnia and hypercapnic hypoxemia

Wetterberg, T; Sjöberg, Trygve LU and Steen, Stig LU (1994) In Acta Anaesthesiologica Scandinavica 38(3). p.293-299
Abstract
Anesthetized, paralyzed and mechanically ventilated pigs were hypoventilated to extreme hypercapnia (PaCO2 approximately 20 kPa) at FiO2 0.5, and allotted to receive hypothermia (approximately 31.5 degrees C) and buffer infusion, (HB-group, n = 6) or to a hypothermic control group (H-group, n = 6). The HB-group had higher arterial pH (7.34 vs 7.09, P < 0.01) and plasma bicarbonate (58.8 vs 35.4 mmol.l-1, P < 0.01) than the controls, but lower mean pulmonary arterial pressure (MPAP), (16 vs 23 mmHg (2.1 vs 3.1 kPa), P < 0.01) and pulmonary vascular resistance (PVR), (512 vs 699 dyn.s.cm-5 (5120 vs 6990 microN.s.cm-5), P < 0.05). Mixed venous PO2 (PVO2) was lower in the HB-group (5.1 vs 6.8 kPa, P < 0.01), as well as serum... (More)
Anesthetized, paralyzed and mechanically ventilated pigs were hypoventilated to extreme hypercapnia (PaCO2 approximately 20 kPa) at FiO2 0.5, and allotted to receive hypothermia (approximately 31.5 degrees C) and buffer infusion, (HB-group, n = 6) or to a hypothermic control group (H-group, n = 6). The HB-group had higher arterial pH (7.34 vs 7.09, P < 0.01) and plasma bicarbonate (58.8 vs 35.4 mmol.l-1, P < 0.01) than the controls, but lower mean pulmonary arterial pressure (MPAP), (16 vs 23 mmHg (2.1 vs 3.1 kPa), P < 0.01) and pulmonary vascular resistance (PVR), (512 vs 699 dyn.s.cm-5 (5120 vs 6990 microN.s.cm-5), P < 0.05). Mixed venous PO2 (PVO2) was lower in the HB-group (5.1 vs 6.8 kPa, P < 0.01), as well as serum potassium (2.8 vs 3.7 mmol.l-1, P < 0.01) and ionized calcium (1.01 vs 1.29 mmol.l-1, P < 0.01). Subsequently, the inspired oxygen fraction (FiO2) was decreased stepwise (0.3, 0.25, 0.21, 0.15, 0.10) at 30 min intervals. At FiO2 0.3, the HB-group had lower PVO2 (6.6 vs 7.8 kPa, P < 0.01), O2 half saturation tension (3.6 vs 4.2 kPa, P < 0.01), MPAP (17 vs 25 mmHg (2.3 vs 3.3 kPa, P < 0.01) and PVR (598 vs 793 dyn.s.cm-5 (5980 vs 7930 microN.s.cm-5, P < 0.05) compared with the controls, but higher arterial O2 saturation (95.3 vs. 88.6%, P < 0.01) and O2 content (17.7 vs 15.7 ml.100 ml-1, P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Acta Anaesthesiologica Scandinavica
volume
38
issue
3
pages
293 - 299
publisher
Wiley-Blackwell
external identifiers
  • pmid:8023672
  • scopus:0028219585
ISSN
0001-5172
language
English
LU publication?
yes
id
edc6603a-46ef-4799-8bf0-953f4eb3bf55 (old id 1108596)
date added to LUP
2008-07-24 13:40:14
date last changed
2017-01-01 04:29:44
@article{edc6603a-46ef-4799-8bf0-953f4eb3bf55,
  abstract     = {Anesthetized, paralyzed and mechanically ventilated pigs were hypoventilated to extreme hypercapnia (PaCO2 approximately 20 kPa) at FiO2 0.5, and allotted to receive hypothermia (approximately 31.5 degrees C) and buffer infusion, (HB-group, n = 6) or to a hypothermic control group (H-group, n = 6). The HB-group had higher arterial pH (7.34 vs 7.09, P &lt; 0.01) and plasma bicarbonate (58.8 vs 35.4 mmol.l-1, P &lt; 0.01) than the controls, but lower mean pulmonary arterial pressure (MPAP), (16 vs 23 mmHg (2.1 vs 3.1 kPa), P &lt; 0.01) and pulmonary vascular resistance (PVR), (512 vs 699 dyn.s.cm-5 (5120 vs 6990 microN.s.cm-5), P &lt; 0.05). Mixed venous PO2 (PVO2) was lower in the HB-group (5.1 vs 6.8 kPa, P &lt; 0.01), as well as serum potassium (2.8 vs 3.7 mmol.l-1, P &lt; 0.01) and ionized calcium (1.01 vs 1.29 mmol.l-1, P &lt; 0.01). Subsequently, the inspired oxygen fraction (FiO2) was decreased stepwise (0.3, 0.25, 0.21, 0.15, 0.10) at 30 min intervals. At FiO2 0.3, the HB-group had lower PVO2 (6.6 vs 7.8 kPa, P &lt; 0.01), O2 half saturation tension (3.6 vs 4.2 kPa, P &lt; 0.01), MPAP (17 vs 25 mmHg (2.3 vs 3.3 kPa, P &lt; 0.01) and PVR (598 vs 793 dyn.s.cm-5 (5980 vs 7930 microN.s.cm-5, P &lt; 0.05) compared with the controls, but higher arterial O2 saturation (95.3 vs. 88.6%, P &lt; 0.01) and O2 content (17.7 vs 15.7 ml.100 ml-1, P &lt; 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)},
  author       = {Wetterberg, T and Sjöberg, Trygve and Steen, Stig},
  issn         = {0001-5172},
  language     = {eng},
  number       = {3},
  pages        = {293--299},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Anaesthesiologica Scandinavica},
  title        = {Effects of hypothermia with and without buffering in hypercapnia and hypercapnic hypoxemia},
  volume       = {38},
  year         = {1994},
}