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Low risk of seizure recurrence after early withdrawal of antiepileptic treatment in the neonatal period

Hellström-Westas, Lena LU ; Blennow, Gösta LU ; Lindroth, Magnus LU ; Rosén, Ingmar LU and Svenningsen, N W (1995) In Archives of Disease in Childhood. Fetal and Neonatal Edition 72(2). p.97-101
Abstract
The risk of seizure recurrence within the first year of life was evaluated in infants with neonatal seizures diagnosed with a combination of clinical signs, amplitude-integrated electroencephalogram (EEG) monitoring, and standard EEG. Fifty eight of 283 (4.5%) neonates in tertiary level neonatal intensive care had seizures. The mortality in the infants with neonatal seizures was 36.2%. In 31 surviving infants antiepileptic treatment was discontinued after one to 65 days (median 4.5 days). Three infants received no antiepileptic treatment, two continued with prophylactic antiepileptic treatment. Seizure recurrence was present in only three cases (8.3%)--one infant receiving prophylaxis, one treated for 65 days, and in one infant treated for... (More)
The risk of seizure recurrence within the first year of life was evaluated in infants with neonatal seizures diagnosed with a combination of clinical signs, amplitude-integrated electroencephalogram (EEG) monitoring, and standard EEG. Fifty eight of 283 (4.5%) neonates in tertiary level neonatal intensive care had seizures. The mortality in the infants with neonatal seizures was 36.2%. In 31 surviving infants antiepileptic treatment was discontinued after one to 65 days (median 4.5 days). Three infants received no antiepileptic treatment, two continued with prophylactic antiepileptic treatment. Seizure recurrence was present in only three cases (8.3%)--one infant receiving prophylaxis, one treated for 65 days, and in one infant treated for six days. Owing to the small number of infants with seizure recurrence, no clinical features could be specifically related to an increased risk of subsequent seizures. When administering antiepileptic treatment, one aim was to abolish both clinical and electrographical seizures. Another goal was to minimise the duration of treatment and to keep the treatment as short as possible. It is suggested that treating neonatal seizures in this way may not only reduce the risk of subsequent seizure recurrence, but may also minimise unnecessary non-specific prophylactic treatment for epilepsy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Archives of Disease in Childhood. Fetal and Neonatal Edition
volume
72
issue
2
pages
97 - 101
publisher
BMJ Publishing Group
external identifiers
  • pmid:7712281
  • scopus:0028949445
ISSN
1359-2998
language
English
LU publication?
yes
id
b3075a56-aee7-4882-a772-012e1c634eec (old id 1108746)
alternative location
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528399/
date added to LUP
2008-07-24 16:05:55
date last changed
2017-07-09 04:30:08
@article{b3075a56-aee7-4882-a772-012e1c634eec,
  abstract     = {The risk of seizure recurrence within the first year of life was evaluated in infants with neonatal seizures diagnosed with a combination of clinical signs, amplitude-integrated electroencephalogram (EEG) monitoring, and standard EEG. Fifty eight of 283 (4.5%) neonates in tertiary level neonatal intensive care had seizures. The mortality in the infants with neonatal seizures was 36.2%. In 31 surviving infants antiepileptic treatment was discontinued after one to 65 days (median 4.5 days). Three infants received no antiepileptic treatment, two continued with prophylactic antiepileptic treatment. Seizure recurrence was present in only three cases (8.3%)--one infant receiving prophylaxis, one treated for 65 days, and in one infant treated for six days. Owing to the small number of infants with seizure recurrence, no clinical features could be specifically related to an increased risk of subsequent seizures. When administering antiepileptic treatment, one aim was to abolish both clinical and electrographical seizures. Another goal was to minimise the duration of treatment and to keep the treatment as short as possible. It is suggested that treating neonatal seizures in this way may not only reduce the risk of subsequent seizure recurrence, but may also minimise unnecessary non-specific prophylactic treatment for epilepsy.},
  author       = {Hellström-Westas, Lena and Blennow, Gösta and Lindroth, Magnus and Rosén, Ingmar and Svenningsen, N W},
  issn         = {1359-2998},
  language     = {eng},
  number       = {2},
  pages        = {97--101},
  publisher    = {BMJ Publishing Group},
  series       = {Archives of Disease in Childhood. Fetal and Neonatal Edition},
  title        = {Low risk of seizure recurrence after early withdrawal of antiepileptic treatment in the neonatal period},
  volume       = {72},
  year         = {1995},
}