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Greater diversity of hepatitis C virus genotypes found in Hong Kong than in mainland China

Zhang, Yong Yuan; Lok, A S; Chan, D T and Widell, Anders LU (1995) In Journal of Clinical Microbiology 33(11). p.2931-2934
Abstract
A hepatitis C virus (HCV) genotyping PCR assay based on type-specific primers was expanded to include genotype 6a as well as genotypes 1a, 1b, 2a, and 3a. The nucleotide sequences of a 194-bp fragment in the center of the HCV core gene showed that the homologies between genotype 6a and genotypes 1a, 1b, 2a, 2b, 3a, and 5 were 81.2, 82.1, 73.8, 77.3, 81.4, and 78.9%, respectively. A high degree of homology (99.6%) was seen in the amplified core region among eight clinically unrelated genotype 6a isolates. Although the Hong Kong Chinese patients had predominantly genotype 1b (70%), it was noteworthy that genotype 6a was the second most common genotype (14%). Four other HCV genotypes--1a, 1b, 2a, and 2b--were also present. In contrast, HCV... (More)
A hepatitis C virus (HCV) genotyping PCR assay based on type-specific primers was expanded to include genotype 6a as well as genotypes 1a, 1b, 2a, and 3a. The nucleotide sequences of a 194-bp fragment in the center of the HCV core gene showed that the homologies between genotype 6a and genotypes 1a, 1b, 2a, 2b, 3a, and 5 were 81.2, 82.1, 73.8, 77.3, 81.4, and 78.9%, respectively. A high degree of homology (99.6%) was seen in the amplified core region among eight clinically unrelated genotype 6a isolates. Although the Hong Kong Chinese patients had predominantly genotype 1b (70%), it was noteworthy that genotype 6a was the second most common genotype (14%). Four other HCV genotypes--1a, 1b, 2a, and 2b--were also present. In contrast, HCV infection by mainland China was confined to genotypes 1b and 2a. Thus, we found a greater diversity of HCV genotypes in Hong Kong than in mainland China. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
in
Journal of Clinical Microbiology
volume
33
issue
11
pages
2931 - 2934
publisher
American Society for Microbiology
external identifiers
  • pmid:8576348
  • scopus:0028834475
ISSN
1098-660X
language
English
LU publication?
yes
id
fa7227a7-a8a4-4579-8808-79470e2c626b (old id 1108788)
alternative location
http://jcm.asm.org/cgi/reprint/33/11/2931?view=long&pmid=8576348
date added to LUP
2008-07-24 16:34:06
date last changed
2017-01-01 06:46:22
@article{fa7227a7-a8a4-4579-8808-79470e2c626b,
  abstract     = {A hepatitis C virus (HCV) genotyping PCR assay based on type-specific primers was expanded to include genotype 6a as well as genotypes 1a, 1b, 2a, and 3a. The nucleotide sequences of a 194-bp fragment in the center of the HCV core gene showed that the homologies between genotype 6a and genotypes 1a, 1b, 2a, 2b, 3a, and 5 were 81.2, 82.1, 73.8, 77.3, 81.4, and 78.9%, respectively. A high degree of homology (99.6%) was seen in the amplified core region among eight clinically unrelated genotype 6a isolates. Although the Hong Kong Chinese patients had predominantly genotype 1b (70%), it was noteworthy that genotype 6a was the second most common genotype (14%). Four other HCV genotypes--1a, 1b, 2a, and 2b--were also present. In contrast, HCV infection by mainland China was confined to genotypes 1b and 2a. Thus, we found a greater diversity of HCV genotypes in Hong Kong than in mainland China.},
  author       = {Zhang, Yong Yuan and Lok, A S and Chan, D T and Widell, Anders},
  issn         = {1098-660X},
  language     = {eng},
  number       = {11},
  pages        = {2931--2934},
  publisher    = {American Society for Microbiology},
  series       = {Journal of Clinical Microbiology},
  title        = {Greater diversity of hepatitis C virus genotypes found in Hong Kong than in mainland China},
  volume       = {33},
  year         = {1995},
}