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Effects of intrapleural mitoxantrone and mepacrine on malignant pleural effusion--a randomised study

Bjermer, Leif LU ; Gruber, A; Sue-Chu, M; Sandström, T; Eksborg, S and Henriksson, R (1995) In European Journal of Cancer 31(13-14). p.2203-2208
Abstract
30 patients with malignant pleuritis were randomised to be treated, either with intrapleural instillation of mepacrine chloride or with mitoxantrone. The patients were evaluated with chest X-ray and a symptom questionnaire during a follow-up period of 12 weeks. Mitoxantrone levels in the pleural space and plasma were measured at different time points in some of the patients. High concentrations of mitoxantrone were found in the pleural fluid while the plasma concentrations were low, giving a plasma/intracavity ratio generally of less than 1:60. The chest X-rays showed excellent results for both treatment modalities. However, the patients treated with mepacrine chloride experienced greater discomfort with fever and pain, and those treated... (More)
30 patients with malignant pleuritis were randomised to be treated, either with intrapleural instillation of mepacrine chloride or with mitoxantrone. The patients were evaluated with chest X-ray and a symptom questionnaire during a follow-up period of 12 weeks. Mitoxantrone levels in the pleural space and plasma were measured at different time points in some of the patients. High concentrations of mitoxantrone were found in the pleural fluid while the plasma concentrations were low, giving a plasma/intracavity ratio generally of less than 1:60. The chest X-rays showed excellent results for both treatment modalities. However, the patients treated with mepacrine chloride experienced greater discomfort with fever and pain, and those treated with mitoxantrone reported significantly less dyspnoea and less asthenia after 4 weeks. We conclude that both treatments are equally effective in preventing the recurrence of malignant effusion. However, mitoxantrone seems to have further advantages when it comes to improving the quality of life. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
malignant pleuritis, mitoxantrone, mepacrine, pleural effusion
in
European Journal of Cancer
volume
31
issue
13-14
pages
2203 - 2208
publisher
IFAC & Elsevier Ltd.
external identifiers
  • pmid:8652243
  • scopus:0029593639
ISSN
1879-0852
DOI
10.1016/0959-8049(95)00425-4
language
English
LU publication?
no
id
2a3edb89-6fb5-406f-87d5-bb309003c418 (old id 1108895)
date added to LUP
2008-07-25 08:51:12
date last changed
2017-07-09 03:41:47
@article{2a3edb89-6fb5-406f-87d5-bb309003c418,
  abstract     = {30 patients with malignant pleuritis were randomised to be treated, either with intrapleural instillation of mepacrine chloride or with mitoxantrone. The patients were evaluated with chest X-ray and a symptom questionnaire during a follow-up period of 12 weeks. Mitoxantrone levels in the pleural space and plasma were measured at different time points in some of the patients. High concentrations of mitoxantrone were found in the pleural fluid while the plasma concentrations were low, giving a plasma/intracavity ratio generally of less than 1:60. The chest X-rays showed excellent results for both treatment modalities. However, the patients treated with mepacrine chloride experienced greater discomfort with fever and pain, and those treated with mitoxantrone reported significantly less dyspnoea and less asthenia after 4 weeks. We conclude that both treatments are equally effective in preventing the recurrence of malignant effusion. However, mitoxantrone seems to have further advantages when it comes to improving the quality of life.},
  author       = {Bjermer, Leif and Gruber, A and Sue-Chu, M and Sandström, T and Eksborg, S and Henriksson, R},
  issn         = {1879-0852},
  keyword      = {malignant pleuritis,mitoxantrone,mepacrine,pleural effusion},
  language     = {eng},
  number       = {13-14},
  pages        = {2203--2208},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Effects of intrapleural mitoxantrone and mepacrine on malignant pleural effusion--a randomised study},
  url          = {http://dx.doi.org/10.1016/0959-8049(95)00425-4},
  volume       = {31},
  year         = {1995},
}