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Selective attenuation of neuropeptide-Y-mediated contractile responses in blood vessels from patients with diabetes mellitus

Lind, H; Erlinge, David LU ; Brunkwall, J and Edvinsson, Lars LU (1995) In Clinical Autonomic Research 5(4). p.191-197
Abstract
Vascular smooth muscle contractile responses to neuropeptide Y, alpha,beta-methyleneATP and noradrenaline were studied in circular segments of isolated vessels with intact endothelium in vitro from 12 patients with diabetes mellitus type 2 (NIDDM) and 12 control subjects. The dilatory effect of acetylcholine was used to test the function of the endothelium. Subcutaneous arteries and veins (diameter 0.1-1.1 mm) were obtained during surgery. There was no difference in contractile responses to noradrenaline or alpha,beta-methyleneATP between diabetic and control vessels. The contractile response to neuropeptide Y, however, was markedly reduced in the diabetic group. The maximal contractile effect (46.0 +/- 14.0%, p < 0.05) but not the... (More)
Vascular smooth muscle contractile responses to neuropeptide Y, alpha,beta-methyleneATP and noradrenaline were studied in circular segments of isolated vessels with intact endothelium in vitro from 12 patients with diabetes mellitus type 2 (NIDDM) and 12 control subjects. The dilatory effect of acetylcholine was used to test the function of the endothelium. Subcutaneous arteries and veins (diameter 0.1-1.1 mm) were obtained during surgery. There was no difference in contractile responses to noradrenaline or alpha,beta-methyleneATP between diabetic and control vessels. The contractile response to neuropeptide Y, however, was markedly reduced in the diabetic group. The maximal contractile effect (46.0 +/- 14.0%, p < 0.05) but not the sensitivity to neuropeptide Y was significantly less in diabetic veins compared to control (107.5 +/- 19.6%). Thus, the attenuation of neuropeptide Y responses was present in humans as previously observed in alloxan-induced diabetes mellitus in rabbits. There was no difference in the dilator effect of acetylcholine between the diabetic and the control group in any of the vessel types, indicating that the difference in vascular reactivity to neuropeptide Y was not endothelium-dependent. In conclusion, the present study has shown that the postjunctional effects of neuropeptide Y, a co-transmitter of the peripheral sympathetic nervous system, is selectively attenuated in diabetes mellitus. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
diabetes mellitus (NIDDM), potassium, neuropeptide Y, noradrenaline, agr, ß-methyleneATP, vasoconstriction
in
Clinical Autonomic Research
volume
5
issue
4
pages
191 - 197
publisher
Springer
external identifiers
  • pmid:8520213
  • scopus:0028979279
ISSN
1619-1560
DOI
10.1007/BF01824006
language
English
LU publication?
yes
id
ad7261bc-5baa-4b6b-a56d-b20ea2a956c0 (old id 1109007)
date added to LUP
2008-07-25 12:04:07
date last changed
2017-01-01 05:06:54
@article{ad7261bc-5baa-4b6b-a56d-b20ea2a956c0,
  abstract     = {Vascular smooth muscle contractile responses to neuropeptide Y, alpha,beta-methyleneATP and noradrenaline were studied in circular segments of isolated vessels with intact endothelium in vitro from 12 patients with diabetes mellitus type 2 (NIDDM) and 12 control subjects. The dilatory effect of acetylcholine was used to test the function of the endothelium. Subcutaneous arteries and veins (diameter 0.1-1.1 mm) were obtained during surgery. There was no difference in contractile responses to noradrenaline or alpha,beta-methyleneATP between diabetic and control vessels. The contractile response to neuropeptide Y, however, was markedly reduced in the diabetic group. The maximal contractile effect (46.0 +/- 14.0%, p &lt; 0.05) but not the sensitivity to neuropeptide Y was significantly less in diabetic veins compared to control (107.5 +/- 19.6%). Thus, the attenuation of neuropeptide Y responses was present in humans as previously observed in alloxan-induced diabetes mellitus in rabbits. There was no difference in the dilator effect of acetylcholine between the diabetic and the control group in any of the vessel types, indicating that the difference in vascular reactivity to neuropeptide Y was not endothelium-dependent. In conclusion, the present study has shown that the postjunctional effects of neuropeptide Y, a co-transmitter of the peripheral sympathetic nervous system, is selectively attenuated in diabetes mellitus.},
  author       = {Lind, H and Erlinge, David and Brunkwall, J and Edvinsson, Lars},
  issn         = {1619-1560},
  keyword      = {diabetes mellitus (NIDDM),potassium,neuropeptide Y,noradrenaline,agr,ß-methyleneATP,vasoconstriction},
  language     = {eng},
  number       = {4},
  pages        = {191--197},
  publisher    = {Springer},
  series       = {Clinical Autonomic Research},
  title        = {Selective attenuation of neuropeptide-Y-mediated contractile responses in blood vessels from patients with diabetes mellitus},
  url          = {http://dx.doi.org/10.1007/BF01824006},
  volume       = {5},
  year         = {1995},
}