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The gene encoding protein D (hpd) is highly conserved among Haemophilus influenzae type b and nontypeable strains

Song, Xin-Ming; Forsgren, Arne LU and Janson, Håkan LU (1995) In Infection and Immunity 63(2). p.696-699
Abstract
The molecular conservation of a surface-exposed lipoprotein, protein D, of Haemophilus influenzae was studied by cloning and sequencing of the gene encoding protein D from three encapsulated type b strains and three nontypeable strains of H. influenzae. These nucleotide sequences were analyzed with previously reported sequences from one type b strain and one nontypeable strain. The nucleotide sequences and the deduced amino acid sequences for protein D were highly conserved. The deduced amino acid sequence (364 amino acids) of protein D from six strains differed only in two amino acids near the C-terminal end. The remaining two strains, one type b and one nontypeable, differed from the consensus sequence in 7 amino acids each. Protein D is... (More)
The molecular conservation of a surface-exposed lipoprotein, protein D, of Haemophilus influenzae was studied by cloning and sequencing of the gene encoding protein D from three encapsulated type b strains and three nontypeable strains of H. influenzae. These nucleotide sequences were analyzed with previously reported sequences from one type b strain and one nontypeable strain. The nucleotide sequences and the deduced amino acid sequences for protein D were highly conserved. The deduced amino acid sequence (364 amino acids) of protein D from six strains differed only in two amino acids near the C-terminal end. The remaining two strains, one type b and one nontypeable, differed from the consensus sequence in 7 amino acids each. Protein D is 64 and 36% identical and 77 and 56% similar to the glycerophosphodiester phosphodiesterases (GlpQ) of Escherichia coli and Bacillus subtilis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Infection and Immunity
volume
63
issue
2
pages
696 - 699
publisher
American Society for Microbiology
external identifiers
  • pmid:7822043
  • scopus:0028942233
ISSN
1098-5522
language
English
LU publication?
yes
id
4626e675-fa7c-4623-bce4-3e2f76435647 (old id 1109019)
alternative location
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=173053
date added to LUP
2008-07-25 12:23:57
date last changed
2017-01-15 03:37:30
@article{4626e675-fa7c-4623-bce4-3e2f76435647,
  abstract     = {The molecular conservation of a surface-exposed lipoprotein, protein D, of Haemophilus influenzae was studied by cloning and sequencing of the gene encoding protein D from three encapsulated type b strains and three nontypeable strains of H. influenzae. These nucleotide sequences were analyzed with previously reported sequences from one type b strain and one nontypeable strain. The nucleotide sequences and the deduced amino acid sequences for protein D were highly conserved. The deduced amino acid sequence (364 amino acids) of protein D from six strains differed only in two amino acids near the C-terminal end. The remaining two strains, one type b and one nontypeable, differed from the consensus sequence in 7 amino acids each. Protein D is 64 and 36% identical and 77 and 56% similar to the glycerophosphodiester phosphodiesterases (GlpQ) of Escherichia coli and Bacillus subtilis.},
  author       = {Song, Xin-Ming and Forsgren, Arne and Janson, Håkan},
  issn         = {1098-5522},
  language     = {eng},
  number       = {2},
  pages        = {696--699},
  publisher    = {American Society for Microbiology},
  series       = {Infection and Immunity},
  title        = {The gene encoding protein D (hpd) is highly conserved among Haemophilus influenzae type b and nontypeable strains},
  volume       = {63},
  year         = {1995},
}