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Environment influences functional outcome of cerebral infarction in rats

Ohlsson, Anna-Lena and Johansson, Barbro LU (1995) In Stroke: a journal of cerebral circulation 26(4). p.644-649
Abstract
BACKGROUND AND PURPOSE: The purpose of this study was to determine whether preoperative and postoperative enrichment of the environment can enhance the functional outcome after cerebral infarction in rats. METHODS: The right middle cerebral artery was ligated in adult spontaneously hypertensive male rats, and the functional outcome was studied for 12 weeks after the operation. Three groups were compared: A, rats kept in individual cages before and after the operation (n = 9); B, rats kept in individual cages before the operation but transferred to an enriched environment after the operation (n = 10); and C, rats kept in an enriched environment all the time (n = 12). The enriched environment consisted of a large cage with opportunities for... (More)
BACKGROUND AND PURPOSE: The purpose of this study was to determine whether preoperative and postoperative enrichment of the environment can enhance the functional outcome after cerebral infarction in rats. METHODS: The right middle cerebral artery was ligated in adult spontaneously hypertensive male rats, and the functional outcome was studied for 12 weeks after the operation. Three groups were compared: A, rats kept in individual cages before and after the operation (n = 9); B, rats kept in individual cages before the operation but transferred to an enriched environment after the operation (n = 10); and C, rats kept in an enriched environment all the time (n = 12). The enriched environment consisted of a large cage with opportunities for various activities, but rats were not forced to do any particular tasks. RESULTS: Rats kept in an enriched environment (groups B and C) performed significantly better than rats in group A in a leg-placement test, beam walking, walking on a rotating pole, and climbing. The infarct size and thalamic atrophy did not differ among the groups. CONCLUSIONS: The laboratory environment is important for the functional outcome in brain ischemia. We hypothesize that an enriched environment may stimulate mechanisms that enhance brain plasticity after focal brain ischemia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebral infarction, rehabilitation, stroke outcome, rats
in
Stroke: a journal of cerebral circulation
volume
26
issue
4
pages
644 - 649
publisher
American Heart Association
external identifiers
  • pmid:7709412
  • scopus:0028906372
ISSN
1524-4628
language
English
LU publication?
yes
id
4305eadb-9088-4367-9c86-095452cc87af (old id 1109165)
alternative location
http://stroke.ahajournals.org/cgi/content/full/26/4/644
date added to LUP
2008-07-25 14:39:18
date last changed
2017-08-13 04:20:00
@article{4305eadb-9088-4367-9c86-095452cc87af,
  abstract     = {BACKGROUND AND PURPOSE: The purpose of this study was to determine whether preoperative and postoperative enrichment of the environment can enhance the functional outcome after cerebral infarction in rats. METHODS: The right middle cerebral artery was ligated in adult spontaneously hypertensive male rats, and the functional outcome was studied for 12 weeks after the operation. Three groups were compared: A, rats kept in individual cages before and after the operation (n = 9); B, rats kept in individual cages before the operation but transferred to an enriched environment after the operation (n = 10); and C, rats kept in an enriched environment all the time (n = 12). The enriched environment consisted of a large cage with opportunities for various activities, but rats were not forced to do any particular tasks. RESULTS: Rats kept in an enriched environment (groups B and C) performed significantly better than rats in group A in a leg-placement test, beam walking, walking on a rotating pole, and climbing. The infarct size and thalamic atrophy did not differ among the groups. CONCLUSIONS: The laboratory environment is important for the functional outcome in brain ischemia. We hypothesize that an enriched environment may stimulate mechanisms that enhance brain plasticity after focal brain ischemia.},
  author       = {Ohlsson, Anna-Lena and Johansson, Barbro},
  issn         = {1524-4628},
  keyword      = {cerebral infarction,rehabilitation,stroke outcome,rats},
  language     = {eng},
  number       = {4},
  pages        = {644--649},
  publisher    = {American Heart Association},
  series       = { Stroke: a journal of cerebral circulation},
  title        = {Environment influences functional outcome of cerebral infarction in rats},
  volume       = {26},
  year         = {1995},
}