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Autonomic nerve dysfunction in patients with bolus-specific esophageal dysmotility

Ekberg, Olle LU ; Olsson, Rolf LU ; Nilsson, Håkan; Lilja, Bo and Sundkvist, Göran LU (1995) In Dysphagia 10(1). p.44-48
Abstract
The pathogenetic mechanisms causing esophageal dysmotility is not well understood. We examined 13 patients with solid bolus dysphagia in a radiologic barium study including the swallowing of a 14-mm tablet. In all 13 patients the tablet was caught in the proximal or midesophagus. In 8 patients, the entrapment was associated with symptoms (Group 1) whereas in 5 patients (Group 2), no symptoms were reported. All 13 patients together with a control group of 56 healthy, nondysphagic subjects were tested for autonomic nerve function. Autonomic nerve function tests included registration of electrocardiographic R-R interval variation during deep breathing test (E/I ratio), a test of parasympathetic, vagal, nerve function. The results showed that... (More)
The pathogenetic mechanisms causing esophageal dysmotility is not well understood. We examined 13 patients with solid bolus dysphagia in a radiologic barium study including the swallowing of a 14-mm tablet. In all 13 patients the tablet was caught in the proximal or midesophagus. In 8 patients, the entrapment was associated with symptoms (Group 1) whereas in 5 patients (Group 2), no symptoms were reported. All 13 patients together with a control group of 56 healthy, nondysphagic subjects were tested for autonomic nerve function. Autonomic nerve function tests included registration of electrocardiographic R-R interval variation during deep breathing test (E/I ratio), a test of parasympathetic, vagal, nerve function. The results showed that the E/I ratio was significantly lower in patients with symptoms of bolus-specific esophageal dysmotility (-2,19 [1.76]) (median [interquartile range]) compared with patients without symptoms (0.05 [2, 87], p = 0.0192) and controls (-0.25 [1.26], p = 0.0009). In conclusion, symptomatic bolus-specific esophageal dysmotility is associated with vagal nerve dysfunction. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Esophagus, Foreign body, Deglutition, Deglutition disorders, Autonomic nerve dysfunction
in
Dysphagia
volume
10
issue
1
pages
44 - 48
publisher
Springer
external identifiers
  • pmid:7859533
  • scopus:0028873212
ISSN
1432-0460
DOI
10.1007/BF00261280
language
English
LU publication?
yes
id
7cf45a03-9a4e-469c-baac-a0d25be4fea0 (old id 1109201)
date added to LUP
2008-07-25 15:47:23
date last changed
2017-01-01 04:20:49
@article{7cf45a03-9a4e-469c-baac-a0d25be4fea0,
  abstract     = {The pathogenetic mechanisms causing esophageal dysmotility is not well understood. We examined 13 patients with solid bolus dysphagia in a radiologic barium study including the swallowing of a 14-mm tablet. In all 13 patients the tablet was caught in the proximal or midesophagus. In 8 patients, the entrapment was associated with symptoms (Group 1) whereas in 5 patients (Group 2), no symptoms were reported. All 13 patients together with a control group of 56 healthy, nondysphagic subjects were tested for autonomic nerve function. Autonomic nerve function tests included registration of electrocardiographic R-R interval variation during deep breathing test (E/I ratio), a test of parasympathetic, vagal, nerve function. The results showed that the E/I ratio was significantly lower in patients with symptoms of bolus-specific esophageal dysmotility (-2,19 [1.76]) (median [interquartile range]) compared with patients without symptoms (0.05 [2, 87], p = 0.0192) and controls (-0.25 [1.26], p = 0.0009). In conclusion, symptomatic bolus-specific esophageal dysmotility is associated with vagal nerve dysfunction.},
  author       = {Ekberg, Olle and Olsson, Rolf and Nilsson, Håkan and Lilja, Bo and Sundkvist, Göran},
  issn         = {1432-0460},
  keyword      = {Esophagus,Foreign body,Deglutition,Deglutition disorders,Autonomic nerve dysfunction},
  language     = {eng},
  number       = {1},
  pages        = {44--48},
  publisher    = {Springer},
  series       = {Dysphagia},
  title        = {Autonomic nerve dysfunction in patients with bolus-specific esophageal dysmotility},
  url          = {http://dx.doi.org/10.1007/BF00261280},
  volume       = {10},
  year         = {1995},
}