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Long-term metabolic effects of urinary diversion on skeletal bone: histomorphometric and mineralogic analysis

Davidsson, Thomas LU ; Lindergård, Birger LU ; Obrant, Karl LU and Månsson, Wiking LU (1995) In Urology 46(3). p.328-333
Abstract
OBJECTIVES. To evaluate the long-term influence of different types of intestinal urinary diversion on skeletal bone and its mineral content. METHODS. Densitometry was used to estimate bone mineral content, and bone biopsies were analyzed with histomorphometric technique. The study comprised 20 patients with conduit urinary diversion and 19 with cecal continent reservoir, all followed up for more than 5 years, with normal or near-normal renal function. RESULTS. Bone mineral content did not differ significantly between the patients with cecal continent urinary reservoir and those with conduit diversion or between these groups and a reference group. At the cellular level, the histomorphometric analysis revealed no defective bone... (More)
OBJECTIVES. To evaluate the long-term influence of different types of intestinal urinary diversion on skeletal bone and its mineral content. METHODS. Densitometry was used to estimate bone mineral content, and bone biopsies were analyzed with histomorphometric technique. The study comprised 20 patients with conduit urinary diversion and 19 with cecal continent reservoir, all followed up for more than 5 years, with normal or near-normal renal function. RESULTS. Bone mineral content did not differ significantly between the patients with cecal continent urinary reservoir and those with conduit diversion or between these groups and a reference group. At the cellular level, the histomorphometric analysis revealed no defective bone mineralization or increased bone resorption in either group of patients. The trabecular bone volume was greater than normal in the reservoir group, but not in the conduit group. The appositional rate was significantly below normal in both groups of patients, but did not differ between conduit and reservoir patients. CONCLUSIONS. Subtle changes in electrolytes and acid-base homeostasis identified in adults with intestinal segments incorporated in the urinary tract and with largely normal renal function do not seem to influence bone mineralization in the long term. At the cellular level, a lower than normal appositional rate was found in the patients with conduit or continent urinary diversion. In the latter group, this finding, together with increased trabecular bone volume, may indicate a decrease of bone turnover. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Urology
volume
46
issue
3
pages
328 - 333
publisher
Elsevier
external identifiers
  • pmid:7660507
  • scopus:0028838587
ISSN
1527-9995
DOI
10.1016/S0090-4295(99)80215-5
language
English
LU publication?
yes
id
fcaae82b-68d7-4b5f-b249-7fdbabc8ecf2 (old id 1109234)
date added to LUP
2008-07-25 16:13:08
date last changed
2017-02-22 11:44:08
@article{fcaae82b-68d7-4b5f-b249-7fdbabc8ecf2,
  abstract     = {OBJECTIVES. To evaluate the long-term influence of different types of intestinal urinary diversion on skeletal bone and its mineral content. METHODS. Densitometry was used to estimate bone mineral content, and bone biopsies were analyzed with histomorphometric technique. The study comprised 20 patients with conduit urinary diversion and 19 with cecal continent reservoir, all followed up for more than 5 years, with normal or near-normal renal function. RESULTS. Bone mineral content did not differ significantly between the patients with cecal continent urinary reservoir and those with conduit diversion or between these groups and a reference group. At the cellular level, the histomorphometric analysis revealed no defective bone mineralization or increased bone resorption in either group of patients. The trabecular bone volume was greater than normal in the reservoir group, but not in the conduit group. The appositional rate was significantly below normal in both groups of patients, but did not differ between conduit and reservoir patients. CONCLUSIONS. Subtle changes in electrolytes and acid-base homeostasis identified in adults with intestinal segments incorporated in the urinary tract and with largely normal renal function do not seem to influence bone mineralization in the long term. At the cellular level, a lower than normal appositional rate was found in the patients with conduit or continent urinary diversion. In the latter group, this finding, together with increased trabecular bone volume, may indicate a decrease of bone turnover.},
  author       = {Davidsson, Thomas and Lindergård, Birger and Obrant, Karl and Månsson, Wiking},
  issn         = {1527-9995},
  language     = {eng},
  number       = {3},
  pages        = {328--333},
  publisher    = {Elsevier},
  series       = {Urology},
  title        = {Long-term metabolic effects of urinary diversion on skeletal bone: histomorphometric and mineralogic analysis},
  url          = {http://dx.doi.org/10.1016/S0090-4295(99)80215-5},
  volume       = {46},
  year         = {1995},
}