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Neocortical grafts placed in the infarcted brain of adult rats: few or no efferent fibers grow from transplant to host

Grabowski, Martin LU ; Johansson, Barbro LU and Brundin, Patrik LU (1995) In Experimental Neurology 134(2). p.273-276
Abstract
The present study examines the capacity of fetal neocortical grafts placed in a brain infarct to exchange axonal projections with the host brain. Five to 7 days after a middle cerebral artery occlusion in adult spontaneously hypertensive rats, dissociated neocortical primordium from fetuses of gestational age 15-16 days was implanted into the infarcted area. Four to 11 months later, the neural tracers Phaseolus vulgaris-leucoagglutinin and Fluoro-Gold were injected in the grafts and host neocortex. An extensive axonal network was present in the transplants but only one of eight rats with appropriate placed injections displayed efferent connections from transplant to host. The sparse axonal outgrowth indicates major limitations for fetal... (More)
The present study examines the capacity of fetal neocortical grafts placed in a brain infarct to exchange axonal projections with the host brain. Five to 7 days after a middle cerebral artery occlusion in adult spontaneously hypertensive rats, dissociated neocortical primordium from fetuses of gestational age 15-16 days was implanted into the infarcted area. Four to 11 months later, the neural tracers Phaseolus vulgaris-leucoagglutinin and Fluoro-Gold were injected in the grafts and host neocortex. An extensive axonal network was present in the transplants but only one of eight rats with appropriate placed injections displayed efferent connections from transplant to host. The sparse axonal outgrowth indicates major limitations for fetal rat cortical grafts to form connections with host neural circuitries after an ischemic insult. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental Neurology
volume
134
issue
2
pages
273 - 276
publisher
Academic Press
external identifiers
  • pmid:7556547
  • scopus:0028800456
ISSN
0014-4886
DOI
10.1006/exnr.1995.1057
language
English
LU publication?
yes
id
d2970f75-8a1c-431c-b722-43b4b44c41fa (old id 1109343)
date added to LUP
2008-07-28 10:06:19
date last changed
2017-01-01 04:56:26
@article{d2970f75-8a1c-431c-b722-43b4b44c41fa,
  abstract     = {The present study examines the capacity of fetal neocortical grafts placed in a brain infarct to exchange axonal projections with the host brain. Five to 7 days after a middle cerebral artery occlusion in adult spontaneously hypertensive rats, dissociated neocortical primordium from fetuses of gestational age 15-16 days was implanted into the infarcted area. Four to 11 months later, the neural tracers Phaseolus vulgaris-leucoagglutinin and Fluoro-Gold were injected in the grafts and host neocortex. An extensive axonal network was present in the transplants but only one of eight rats with appropriate placed injections displayed efferent connections from transplant to host. The sparse axonal outgrowth indicates major limitations for fetal rat cortical grafts to form connections with host neural circuitries after an ischemic insult.},
  author       = {Grabowski, Martin and Johansson, Barbro and Brundin, Patrik},
  issn         = {0014-4886},
  language     = {eng},
  number       = {2},
  pages        = {273--276},
  publisher    = {Academic Press},
  series       = {Experimental Neurology},
  title        = {Neocortical grafts placed in the infarcted brain of adult rats: few or no efferent fibers grow from transplant to host},
  url          = {http://dx.doi.org/10.1006/exnr.1995.1057},
  volume       = {134},
  year         = {1995},
}