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Oxidative activation of the propolis hapten isoprenyl caffeate

Hansson, Christer LU ; Ezzelarab, M and Sterner, Olov LU (1995) In Acta Dermato-Venereologica 75(1). p.34-36
Abstract
The reactions of isoprenyl caffeate, the strongest allergen known to be present in propolis, with plausible functional groups of proteins were studied. The thiols glutathione and cysteine, which add to isoprenyl caffeate after having been oxidised to the corresponding quinone, served as model substances. The structure of the thiol adducts was determined by spectroscopic methods, addition being found to occur at C-2. The results support the hypothesis that the catecholic propolis hapten is a pro-hapten that forms a complete antigen after oxidation to caffeate quinone and addition to nucleophilic groups of proteins.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Dermato-Venereologica
volume
75
issue
1
pages
34 - 36
publisher
Medical Journals Limited
external identifiers
  • pmid:7747533
  • scopus:0028891099
ISSN
1651-2057
language
English
LU publication?
yes
id
b8a0d6fc-4764-4547-b5b5-bc3098561fa0 (old id 1109439)
date added to LUP
2008-07-28 14:38:32
date last changed
2017-01-01 07:24:07
@article{b8a0d6fc-4764-4547-b5b5-bc3098561fa0,
  abstract     = {The reactions of isoprenyl caffeate, the strongest allergen known to be present in propolis, with plausible functional groups of proteins were studied. The thiols glutathione and cysteine, which add to isoprenyl caffeate after having been oxidised to the corresponding quinone, served as model substances. The structure of the thiol adducts was determined by spectroscopic methods, addition being found to occur at C-2. The results support the hypothesis that the catecholic propolis hapten is a pro-hapten that forms a complete antigen after oxidation to caffeate quinone and addition to nucleophilic groups of proteins.},
  author       = {Hansson, Christer and Ezzelarab, M and Sterner, Olov},
  issn         = {1651-2057},
  language     = {eng},
  number       = {1},
  pages        = {34--36},
  publisher    = {Medical Journals Limited},
  series       = {Acta Dermato-Venereologica},
  title        = {Oxidative activation of the propolis hapten isoprenyl caffeate},
  volume       = {75},
  year         = {1995},
}