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An experimental study of gastric stump carcinoma in Wistar rats

Ehrnström, Roy LU ; Lindstrom, C G; Arvidsson, S; Sternby, Nils LU ; Nilsson, E and Ehrnstrom, Y M (1995) In Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS) 103(12). p.878-884
Abstract
The risk of gastric stump carcinoma is increased 15-20 years after gastric resection for benign disease. Reflux of duodenal juice, bacterial overgrowth and formation of N-nitroso compounds are possible etiological factors. There is a geographical variation in the incidence of gastric cancer, possibly explained by differences in food intake. Experimentally it is possible to induce gastric stump carcinoma in rats without the addition of exogenous carcinogens. The aim of this study was: 1) to find the incidence of gastric carcinoma in rats subjected to BII resection and followed for 10 months, and 2) to examine if acetic acid, a common dietary factor, could influence the development of gastric carcinoma. Amongst BII-operated male Wistar rats,... (More)
The risk of gastric stump carcinoma is increased 15-20 years after gastric resection for benign disease. Reflux of duodenal juice, bacterial overgrowth and formation of N-nitroso compounds are possible etiological factors. There is a geographical variation in the incidence of gastric cancer, possibly explained by differences in food intake. Experimentally it is possible to induce gastric stump carcinoma in rats without the addition of exogenous carcinogens. The aim of this study was: 1) to find the incidence of gastric carcinoma in rats subjected to BII resection and followed for 10 months, and 2) to examine if acetic acid, a common dietary factor, could influence the development of gastric carcinoma. Amongst BII-operated male Wistar rats, infiltrating carcinoma was found in 5/20 on a normal diet and in 5/24 exposed to acetic acid (NS). Benign mucosal changes were seen in 12/20 and 16/24 respectively (NS). With the exception of a profound inflammation in one sham-operated animal, no mucosal pathological changes were found in 24 sham-operated and 24 control animals where no operation was performed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)
volume
103
issue
12
pages
878 - 884
publisher
John Wiley & Sons
external identifiers
  • pmid:8562028
  • scopus:0029561504
ISSN
1600-0463
language
English
LU publication?
yes
id
0ce1fe8c-8a7a-4c45-8637-8fffaf3dd2ab (old id 1109767)
date added to LUP
2008-07-29 15:40:38
date last changed
2017-01-01 04:31:15
@article{0ce1fe8c-8a7a-4c45-8637-8fffaf3dd2ab,
  abstract     = {The risk of gastric stump carcinoma is increased 15-20 years after gastric resection for benign disease. Reflux of duodenal juice, bacterial overgrowth and formation of N-nitroso compounds are possible etiological factors. There is a geographical variation in the incidence of gastric cancer, possibly explained by differences in food intake. Experimentally it is possible to induce gastric stump carcinoma in rats without the addition of exogenous carcinogens. The aim of this study was: 1) to find the incidence of gastric carcinoma in rats subjected to BII resection and followed for 10 months, and 2) to examine if acetic acid, a common dietary factor, could influence the development of gastric carcinoma. Amongst BII-operated male Wistar rats, infiltrating carcinoma was found in 5/20 on a normal diet and in 5/24 exposed to acetic acid (NS). Benign mucosal changes were seen in 12/20 and 16/24 respectively (NS). With the exception of a profound inflammation in one sham-operated animal, no mucosal pathological changes were found in 24 sham-operated and 24 control animals where no operation was performed.},
  author       = {Ehrnström, Roy and Lindstrom, C G and Arvidsson, S and Sternby, Nils and Nilsson, E and Ehrnstrom, Y M},
  issn         = {1600-0463},
  language     = {eng},
  number       = {12},
  pages        = {878--884},
  publisher    = {John Wiley & Sons},
  series       = {Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)},
  title        = {An experimental study of gastric stump carcinoma in Wistar rats},
  volume       = {103},
  year         = {1995},
}