Advanced

Ethanol exposure increases expression of c-jun and junD in human neuroblastoma cells

Ding, Wei-Qun; Larsson, Christer LU and Alling, Christer LU (1996) In NeuroReport 7(13). p.2191-2195
Abstract
The aim of this study was to investigate the effect of ethanol exposure on the expression of fos and jun genes. Exposure of human neuroblastoma SH-SY5Y cells to ethanol for 2-4 days caused a dose-dependent increase in c-jun and junD mRNA levels, whereas mRNAs for c-fos, fosB and junB were not detectable in control or ethanol-treated cells. Four days of ethanol exposure also enhanced the AP-1 binding activity. Experiments with actinomycin D demonstrated that ethanol did not influence the degradation of c-jun and junD mRNAs. These results demonstrate that long-term exposure to ethanol increases c-jun and junD expression. This effect may be one of the mechanisms through which ethanol influences the gene regulatory system in neuronal cells.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NeuroReport
volume
7
issue
13
pages
2191 - 2195
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:8930987
  • scopus:0029807746
ISSN
1473-558X
language
English
LU publication?
yes
id
e50eca0f-bd2c-456a-b108-7875b2f17738 (old id 1109864)
date added to LUP
2008-07-22 10:45:02
date last changed
2017-01-01 05:07:16
@article{e50eca0f-bd2c-456a-b108-7875b2f17738,
  abstract     = {The aim of this study was to investigate the effect of ethanol exposure on the expression of fos and jun genes. Exposure of human neuroblastoma SH-SY5Y cells to ethanol for 2-4 days caused a dose-dependent increase in c-jun and junD mRNA levels, whereas mRNAs for c-fos, fosB and junB were not detectable in control or ethanol-treated cells. Four days of ethanol exposure also enhanced the AP-1 binding activity. Experiments with actinomycin D demonstrated that ethanol did not influence the degradation of c-jun and junD mRNAs. These results demonstrate that long-term exposure to ethanol increases c-jun and junD expression. This effect may be one of the mechanisms through which ethanol influences the gene regulatory system in neuronal cells.},
  author       = {Ding, Wei-Qun and Larsson, Christer and Alling, Christer},
  issn         = {1473-558X},
  language     = {eng},
  number       = {13},
  pages        = {2191--2195},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Ethanol exposure increases expression of c-jun and junD in human neuroblastoma cells},
  volume       = {7},
  year         = {1996},
}