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Chromosome aberrations in prophylactic mastectomies from women belonging to breast cancer families

Petersson, C; Pandis, N; Mertens, F LU ; Adeyinka, A LU ; Ingvar, C LU ; Ringberg, A LU ; Idvall, I LU ; Bondeson, L LU ; Borg, A LU and Olsson, Håkan LU , et al. (1996) In Genes, Chromosomes and Cancer 16(3). p.185-188
Abstract

Short-term cultures of samples from eight prophylactic mastectomies from five unrelated women who were genetically predisposed to breast cancer were analyzed cytogenetically. Clonal chromosome abnormalities were detected in five breasts. Three samples from two women had aberrations involving the short arm of chromosome 3, with a breakpoint in 3p14 in common. Three samples from three women had rearrangements of 1q. Two of them, one of which also displayed a 3p14 rearrangement, shared a breakpoint in 1q41. Both 1q41 and, in particular, 3p14 have been reported to be rearranged frequently in malignant breast proliferations. Whether alterations of genes in these bands are essential in mammary tumorigenesis and, if so, whether they are... (More)

Short-term cultures of samples from eight prophylactic mastectomies from five unrelated women who were genetically predisposed to breast cancer were analyzed cytogenetically. Clonal chromosome abnormalities were detected in five breasts. Three samples from two women had aberrations involving the short arm of chromosome 3, with a breakpoint in 3p14 in common. Three samples from three women had rearrangements of 1q. Two of them, one of which also displayed a 3p14 rearrangement, shared a breakpoint in 1q41. Both 1q41 and, in particular, 3p14 have been reported to be rearranged frequently in malignant breast proliferations. Whether alterations of genes in these bands are essential in mammary tumorigenesis and, if so, whether they are equally important in sporadic and in hereditary cases remains to be explored.

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Adult, Breast Neoplasms, Cells, Cultured, Chromosome Aberrations, Female, Genetic Diseases, Inborn, Humans, Hyperplasia, Karyotyping, Mastectomy, Middle Aged, Precancerous Conditions, Risk Factors, Case Reports, Journal Article, Research Support, Non-U.S. Gov't
in
Genes, Chromosomes and Cancer
volume
16
issue
3
pages
4 pages
publisher
John Wiley & Sons
external identifiers
  • pmid:8814451
  • scopus:8944261589
ISSN
1045-2257
DOI
10.1002/(SICI)1098-2264(199607)16:3<185::AID-GCC5>3.0.CO;2-V
language
English
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yes
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13101c7b-3f4f-47c7-aa49-2d4d623ecf42 (old id 1110127)
date added to LUP
2008-07-29 09:28:35
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2017-04-09 03:45:26
@article{13101c7b-3f4f-47c7-aa49-2d4d623ecf42,
  abstract     = {<p>Short-term cultures of samples from eight prophylactic mastectomies from five unrelated women who were genetically predisposed to breast cancer were analyzed cytogenetically. Clonal chromosome abnormalities were detected in five breasts. Three samples from two women had aberrations involving the short arm of chromosome 3, with a breakpoint in 3p14 in common. Three samples from three women had rearrangements of 1q. Two of them, one of which also displayed a 3p14 rearrangement, shared a breakpoint in 1q41. Both 1q41 and, in particular, 3p14 have been reported to be rearranged frequently in malignant breast proliferations. Whether alterations of genes in these bands are essential in mammary tumorigenesis and, if so, whether they are equally important in sporadic and in hereditary cases remains to be explored.</p>},
  author       = {Petersson, C and Pandis, N and Mertens, F and Adeyinka, A and Ingvar, C and Ringberg, A and Idvall, I and Bondeson, L and Borg, A and Olsson, Håkan and Kristoffersson, U and Mitelman, F},
  issn         = {1045-2257},
  keyword      = {Adult,Breast Neoplasms,Cells, Cultured,Chromosome Aberrations,Female,Genetic Diseases, Inborn,Humans,Hyperplasia,Karyotyping,Mastectomy,Middle Aged,Precancerous Conditions,Risk Factors,Case Reports,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {3},
  pages        = {185--188},
  publisher    = {John Wiley & Sons},
  series       = {Genes, Chromosomes and Cancer},
  title        = {Chromosome aberrations in prophylactic mastectomies from women belonging to breast cancer families},
  url          = {http://dx.doi.org/10.1002/(SICI)1098-2264(199607)16:3<185::AID-GCC5>3.0.CO;2-V},
  volume       = {16},
  year         = {1996},
}