Advanced

Reovirus type 1 associated with meningitis

Johansson, Hugo LU ; Sveger, Tomas LU ; Ahlfors, Karin; Ekstrand, Jarl and Svensson, Lennart (1996) In Scandinavian Journal of Infectious Diseases 28(2). p.117-120
Abstract
A previously healthy 3-month-old girl presented with symptoms of meningitis, diarrhoea, vomiting and fever. Green monkey kidney (GMK) cells inoculated with cerebrospinal fluid (CSF) revealed reovirus-like particles by electron microscopy. RNA-gel electrophoresis, immunofluorescence and virus neutralization identified the pathogen isolated from CSF as reovirus type 1. Antibody determination by immunofluorescence of paired sera showed a significant antibody titre rise to the CSF isolate and neutralization test revealed a greater than 4-fold antibody titre rise to the CSF isolate. The CSF isolate was also neutralized by reovirus type 1 antibodies. This report represents one of a few associating reovirus with CNS symptoms in humans.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
28
issue
2
pages
117 - 120
publisher
Informa Healthcare
external identifiers
  • pmid:8792475
  • scopus:0030001319
ISSN
1651-1980
DOI
10.3109/00365549609049060
language
English
LU publication?
yes
id
c5624b62-7e1b-4573-9008-80abf1c26859 (old id 1110216)
date added to LUP
2008-07-24 10:14:24
date last changed
2017-04-23 04:26:05
@article{c5624b62-7e1b-4573-9008-80abf1c26859,
  abstract     = {A previously healthy 3-month-old girl presented with symptoms of meningitis, diarrhoea, vomiting and fever. Green monkey kidney (GMK) cells inoculated with cerebrospinal fluid (CSF) revealed reovirus-like particles by electron microscopy. RNA-gel electrophoresis, immunofluorescence and virus neutralization identified the pathogen isolated from CSF as reovirus type 1. Antibody determination by immunofluorescence of paired sera showed a significant antibody titre rise to the CSF isolate and neutralization test revealed a greater than 4-fold antibody titre rise to the CSF isolate. The CSF isolate was also neutralized by reovirus type 1 antibodies. This report represents one of a few associating reovirus with CNS symptoms in humans.},
  author       = {Johansson, Hugo and Sveger, Tomas and Ahlfors, Karin and Ekstrand, Jarl and Svensson, Lennart},
  issn         = {1651-1980},
  language     = {eng},
  number       = {2},
  pages        = {117--120},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Reovirus type 1 associated with meningitis},
  url          = {http://dx.doi.org/10.3109/00365549609049060},
  volume       = {28},
  year         = {1996},
}