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Proliferation of the breast epithelium in relation to menstrual cycle phase, hormonal use, and reproductive factors

Olsson, H; Jernström, Helena LU ; Alm, Per LU ; Kreipe, H; Ingvar, Christian LU ; Jönsson, P E and Ryden, S (1996) In Breast Cancer Research and Treatment 40(2). p.187-196
Abstract
The proliferative rate in normal breast epithelium from 58 women undergoing reduction mammoplastics was studied using the formalin resistant antibody Ki-S5, and related to age at operation, menstrual cycle phase, family history of breast cancer, height and weight, parity, and hormonal use. The breast tissue from women operated on in the luteal menstrual cycle phase (day 15-28 among oral contraceptive (OC) users) had significantly higher proliferative rate than breast tissue removed from women in the follicular phase (day 1-14) (p = 0.01). Among women presently exposed to hormones, those with a positive family history of breast cancer among first and second degree relatives had significantly higher values than cases without such history (p... (More)
The proliferative rate in normal breast epithelium from 58 women undergoing reduction mammoplastics was studied using the formalin resistant antibody Ki-S5, and related to age at operation, menstrual cycle phase, family history of breast cancer, height and weight, parity, and hormonal use. The breast tissue from women operated on in the luteal menstrual cycle phase (day 15-28 among oral contraceptive (OC) users) had significantly higher proliferative rate than breast tissue removed from women in the follicular phase (day 1-14) (p = 0.01). Among women presently exposed to hormones, those with a positive family history of breast cancer among first and second degree relatives had significantly higher values than cases without such history (p = 0.02). Weight was not significantly related to proliferation rate, while a short height was associated with a significantly higher proliferation rate (p = 0.04). Women who used OCs before the first full-term pregnancy (FFTP) had a significantly higher proliferation rate compared with never users or late users (p = 0.04). No significant difference was seen between parous versus nulliparous women. The results from the univariate analysis persisted in multivariate models. An especially high proliferation rate was seen in young women with both a positive family history and present hormonal use (p = 0.001). Overall, it was found that young women had a non-significantly higher proliferation rate than older women (p = 0.10). Due to small sample size, these results must be regarded as preliminary, especially in the subgroup analyses. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
benign breast, family history, Ki-S5, menstrual cycle phase, proliferation
in
Breast Cancer Research and Treatment
volume
40
issue
2
pages
187 - 196
publisher
Springer
external identifiers
  • pmid:8879685
  • scopus:0029836095
ISSN
1573-7217
DOI
10.1007/BF01806214
language
English
LU publication?
yes
id
6b9b2f61-b750-461c-9db2-23171ad6f6ff (old id 1110234)
date added to LUP
2008-07-28 10:41:09
date last changed
2017-07-09 04:24:42
@article{6b9b2f61-b750-461c-9db2-23171ad6f6ff,
  abstract     = {The proliferative rate in normal breast epithelium from 58 women undergoing reduction mammoplastics was studied using the formalin resistant antibody Ki-S5, and related to age at operation, menstrual cycle phase, family history of breast cancer, height and weight, parity, and hormonal use. The breast tissue from women operated on in the luteal menstrual cycle phase (day 15-28 among oral contraceptive (OC) users) had significantly higher proliferative rate than breast tissue removed from women in the follicular phase (day 1-14) (p = 0.01). Among women presently exposed to hormones, those with a positive family history of breast cancer among first and second degree relatives had significantly higher values than cases without such history (p = 0.02). Weight was not significantly related to proliferation rate, while a short height was associated with a significantly higher proliferation rate (p = 0.04). Women who used OCs before the first full-term pregnancy (FFTP) had a significantly higher proliferation rate compared with never users or late users (p = 0.04). No significant difference was seen between parous versus nulliparous women. The results from the univariate analysis persisted in multivariate models. An especially high proliferation rate was seen in young women with both a positive family history and present hormonal use (p = 0.001). Overall, it was found that young women had a non-significantly higher proliferation rate than older women (p = 0.10). Due to small sample size, these results must be regarded as preliminary, especially in the subgroup analyses.},
  author       = {Olsson, H and Jernström, Helena and Alm, Per and Kreipe, H and Ingvar, Christian and Jönsson, P E and Ryden, S},
  issn         = {1573-7217},
  keyword      = {benign breast,family history,Ki-S5,menstrual cycle phase,proliferation},
  language     = {eng},
  number       = {2},
  pages        = {187--196},
  publisher    = {Springer},
  series       = {Breast Cancer Research and Treatment},
  title        = {Proliferation of the breast epithelium in relation to menstrual cycle phase, hormonal use, and reproductive factors},
  url          = {http://dx.doi.org/10.1007/BF01806214},
  volume       = {40},
  year         = {1996},
}