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Environmental influence on outcome after experiment brain infarction

Johansson, Barbro LU (1996) In Acta Neurochirurgica. Supplementum 66. p.63-67
Abstract
After permanent ligation of the middle cerebral artery the motor function of rats housed in an enriched environment, i.e. cages with opportunities for various activities but not forcing the rats to do any particular task, is significantly better than in rats housed in individual cages. Rats kept in an enriched environment before and after MCA ligation improved sooner and slightly more than those placed in the enriched environment after ischemia but with no lasting significant difference except for climbing. Preliminary studies suggest that social stimulation is more important than physical activity. Rats with fetal neocortical grafts implanted into the infarct cavity performed better if exposed to enriched environment than grafted control... (More)
After permanent ligation of the middle cerebral artery the motor function of rats housed in an enriched environment, i.e. cages with opportunities for various activities but not forcing the rats to do any particular task, is significantly better than in rats housed in individual cages. Rats kept in an enriched environment before and after MCA ligation improved sooner and slightly more than those placed in the enriched environment after ischemia but with no lasting significant difference except for climbing. Preliminary studies suggest that social stimulation is more important than physical activity. Rats with fetal neocortical grafts implanted into the infarct cavity performed better if exposed to enriched environment than grafted control rats housed in standard laboratory cages with 5 rats in each cage. However, they did not perform better than non-grafted rats housed in the same enriched environment. The infarct size did not differ between rats housed in an enriched environment and control rats. There was no correlation between infarct size and performance in rats exposed to an enriched environment. The improved motor function suggest that a rich environment may stimulate mechanisms that enhance brain plasticity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Neurochirurgica. Supplementum
volume
66
pages
63 - 67
publisher
Springer
external identifiers
  • pmid:8780799
ISSN
0065-1419
language
English
LU publication?
yes
id
12e26528-b344-414c-9988-8921a4edeab6 (old id 1110492)
date added to LUP
2008-07-24 10:02:35
date last changed
2016-04-16 02:59:41
@article{12e26528-b344-414c-9988-8921a4edeab6,
  abstract     = {After permanent ligation of the middle cerebral artery the motor function of rats housed in an enriched environment, i.e. cages with opportunities for various activities but not forcing the rats to do any particular task, is significantly better than in rats housed in individual cages. Rats kept in an enriched environment before and after MCA ligation improved sooner and slightly more than those placed in the enriched environment after ischemia but with no lasting significant difference except for climbing. Preliminary studies suggest that social stimulation is more important than physical activity. Rats with fetal neocortical grafts implanted into the infarct cavity performed better if exposed to enriched environment than grafted control rats housed in standard laboratory cages with 5 rats in each cage. However, they did not perform better than non-grafted rats housed in the same enriched environment. The infarct size did not differ between rats housed in an enriched environment and control rats. There was no correlation between infarct size and performance in rats exposed to an enriched environment. The improved motor function suggest that a rich environment may stimulate mechanisms that enhance brain plasticity.},
  author       = {Johansson, Barbro},
  issn         = {0065-1419},
  language     = {eng},
  pages        = {63--67},
  publisher    = {Springer},
  series       = {Acta Neurochirurgica. Supplementum},
  title        = {Environmental influence on outcome after experiment brain infarction},
  volume       = {66},
  year         = {1996},
}