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Neonatal pre-ganglionic sympathectomy affects morphometrically defined architecture in rat cerebral arteries

Kåhrström, J; Hardebo, Jan Erik LU ; Nordborg, C and Owman, Christer LU (1996) In Acta Physiologica Scandinavica 157(2). p.225-231
Abstract
In order to clarify further the nature of the long-term influence on the cerebral vasculature by the sympathetic nerves, a bilateral cervical pre-ganglionic denervation was performed in 1-week-old rats. Four weeks later, morphometric determinations of the vascular dimensions revealed diminished media cross-sectional areas and luminal radii in the middle cerebral and posterior cerebral arteries, whereas these parameters were unaffected in the basilar artery. In the latter artery, however, a 40% increase in the cross-sectional area of the internal elastic membrane was found. No re-innervation of the denervated ganglia occurred during the course of the experiment. The results suggest that the long-term effect exerted by the sympathetic nerves... (More)
In order to clarify further the nature of the long-term influence on the cerebral vasculature by the sympathetic nerves, a bilateral cervical pre-ganglionic denervation was performed in 1-week-old rats. Four weeks later, morphometric determinations of the vascular dimensions revealed diminished media cross-sectional areas and luminal radii in the middle cerebral and posterior cerebral arteries, whereas these parameters were unaffected in the basilar artery. In the latter artery, however, a 40% increase in the cross-sectional area of the internal elastic membrane was found. No re-innervation of the denervated ganglia occurred during the course of the experiment. The results suggest that the long-term effect exerted by the sympathetic nerves is associated with the nerve activity, rather than being a true trophic influence. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chronic sympathectomy, morphometry, pial arteries, sympathetic nerves, trophic effect
in
Acta Physiologica Scandinavica
volume
157
issue
2
pages
225 - 231
publisher
Wiley-Blackwell
external identifiers
  • pmid:8800363
  • scopus:0029992489
ISSN
0001-6772
DOI
10.1046/j.1365-201X.1996.d01-742.x
language
English
LU publication?
yes
id
7b00a094-94dd-4943-b00b-f09eb9c3e672 (old id 1110665)
date added to LUP
2008-07-24 10:48:24
date last changed
2017-01-01 06:59:58
@article{7b00a094-94dd-4943-b00b-f09eb9c3e672,
  abstract     = {In order to clarify further the nature of the long-term influence on the cerebral vasculature by the sympathetic nerves, a bilateral cervical pre-ganglionic denervation was performed in 1-week-old rats. Four weeks later, morphometric determinations of the vascular dimensions revealed diminished media cross-sectional areas and luminal radii in the middle cerebral and posterior cerebral arteries, whereas these parameters were unaffected in the basilar artery. In the latter artery, however, a 40% increase in the cross-sectional area of the internal elastic membrane was found. No re-innervation of the denervated ganglia occurred during the course of the experiment. The results suggest that the long-term effect exerted by the sympathetic nerves is associated with the nerve activity, rather than being a true trophic influence.},
  author       = {Kåhrström, J and Hardebo, Jan Erik and Nordborg, C and Owman, Christer},
  issn         = {0001-6772},
  keyword      = {chronic sympathectomy,morphometry,pial arteries,sympathetic nerves,trophic effect},
  language     = {eng},
  number       = {2},
  pages        = {225--231},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiologica Scandinavica},
  title        = {Neonatal pre-ganglionic sympathectomy affects morphometrically defined architecture in rat cerebral arteries},
  url          = {http://dx.doi.org/10.1046/j.1365-201X.1996.d01-742.x},
  volume       = {157},
  year         = {1996},
}