Neonatal pre-ganglionic sympathectomy affects morphometrically defined architecture in rat cerebral arteries
(1996) In Acta Physiologica Scandinavica 157(2). p.225-231- Abstract
- In order to clarify further the nature of the long-term influence on the cerebral vasculature by the sympathetic nerves, a bilateral cervical pre-ganglionic denervation was performed in 1-week-old rats. Four weeks later, morphometric determinations of the vascular dimensions revealed diminished media cross-sectional areas and luminal radii in the middle cerebral and posterior cerebral arteries, whereas these parameters were unaffected in the basilar artery. In the latter artery, however, a 40% increase in the cross-sectional area of the internal elastic membrane was found. No re-innervation of the denervated ganglia occurred during the course of the experiment. The results suggest that the long-term effect exerted by the sympathetic nerves... (More)
- In order to clarify further the nature of the long-term influence on the cerebral vasculature by the sympathetic nerves, a bilateral cervical pre-ganglionic denervation was performed in 1-week-old rats. Four weeks later, morphometric determinations of the vascular dimensions revealed diminished media cross-sectional areas and luminal radii in the middle cerebral and posterior cerebral arteries, whereas these parameters were unaffected in the basilar artery. In the latter artery, however, a 40% increase in the cross-sectional area of the internal elastic membrane was found. No re-innervation of the denervated ganglia occurred during the course of the experiment. The results suggest that the long-term effect exerted by the sympathetic nerves is associated with the nerve activity, rather than being a true trophic influence. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1110665
- author
- Kåhrström, J ; Hardebo, Jan Erik LU ; Nordborg, C and Owman, Christer LU
- organization
- publishing date
- 1996
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- chronic sympathectomy, morphometry, pial arteries, sympathetic nerves, trophic effect
- in
- Acta Physiologica Scandinavica
- volume
- 157
- issue
- 2
- pages
- 225 - 231
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:8800363
- scopus:0029992489
- ISSN
- 0001-6772
- DOI
- 10.1046/j.1365-201X.1996.d01-742.x
- language
- English
- LU publication?
- yes
- id
- 7b00a094-94dd-4943-b00b-f09eb9c3e672 (old id 1110665)
- date added to LUP
- 2016-04-01 16:15:00
- date last changed
- 2022-01-28 18:23:05
@article{7b00a094-94dd-4943-b00b-f09eb9c3e672, abstract = {{In order to clarify further the nature of the long-term influence on the cerebral vasculature by the sympathetic nerves, a bilateral cervical pre-ganglionic denervation was performed in 1-week-old rats. Four weeks later, morphometric determinations of the vascular dimensions revealed diminished media cross-sectional areas and luminal radii in the middle cerebral and posterior cerebral arteries, whereas these parameters were unaffected in the basilar artery. In the latter artery, however, a 40% increase in the cross-sectional area of the internal elastic membrane was found. No re-innervation of the denervated ganglia occurred during the course of the experiment. The results suggest that the long-term effect exerted by the sympathetic nerves is associated with the nerve activity, rather than being a true trophic influence.}}, author = {{Kåhrström, J and Hardebo, Jan Erik and Nordborg, C and Owman, Christer}}, issn = {{0001-6772}}, keywords = {{chronic sympathectomy; morphometry; pial arteries; sympathetic nerves; trophic effect}}, language = {{eng}}, number = {{2}}, pages = {{225--231}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Physiologica Scandinavica}}, title = {{Neonatal pre-ganglionic sympathectomy affects morphometrically defined architecture in rat cerebral arteries}}, url = {{http://dx.doi.org/10.1046/j.1365-201X.1996.d01-742.x}}, doi = {{10.1046/j.1365-201X.1996.d01-742.x}}, volume = {{157}}, year = {{1996}}, }