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A Monte-Carlo program converting activity distributions to absorbed dose distributions in a radionuclide treatment planning system

Tagesson, Magnus; Ljungberg, Michael LU and Strand, Sven-Erik LU (1996) In Acta Oncologica 35(3). p.367-372
Abstract
In systemic radiation therapy, the absorbed dose distribution must be calculated from the individual activity distribution. A computer code has been developed for the conversion of an arbitrary activity distribution to a 3-D absorbed dose distribution. The activity distribution can be described either analytically or as a voxel based distribution, which comes from a SPECT acquisition. Decay points are sampled according to the activity map, and particles (photons and electrons) from the decay are followed through the tissue until they either escape the patient or drop below a cut off energy. To verify the calculated results, the mathematically defined MIRD phantom and unity density spheres have been included in the code. Also other... (More)
In systemic radiation therapy, the absorbed dose distribution must be calculated from the individual activity distribution. A computer code has been developed for the conversion of an arbitrary activity distribution to a 3-D absorbed dose distribution. The activity distribution can be described either analytically or as a voxel based distribution, which comes from a SPECT acquisition. Decay points are sampled according to the activity map, and particles (photons and electrons) from the decay are followed through the tissue until they either escape the patient or drop below a cut off energy. To verify the calculated results, the mathematically defined MIRD phantom and unity density spheres have been included in the code. Also other published dosimetry data were used for verification. Absorbed fractions and S-values were calculated. A comparison with simulated data from the code with MIRD data shows good agreement. The S values are within 10-20% of published MIRD S values for most organs. Absorbed fractions for photons and electrons in spheres (masses between 1 g and 200 kg) are within 10-15% of those published. Radial absorbed dose distributions in a necrotic tumor show good agreement with published data. The application of the code in a radionuclide therapy dose planning system, based on quantitative SPECT, is discussed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
35
issue
3
pages
367 - 372
publisher
Taylor & Francis
external identifiers
  • pmid:8679268
  • scopus:0029952594
ISSN
1651-226X
DOI
10.3109/02841869609101653
language
English
LU publication?
yes
id
1d224037-0ee1-4fbc-96a2-b35e45a49b78 (old id 1110840)
date added to LUP
2008-07-30 09:05:08
date last changed
2017-11-19 04:14:50
@article{1d224037-0ee1-4fbc-96a2-b35e45a49b78,
  abstract     = {In systemic radiation therapy, the absorbed dose distribution must be calculated from the individual activity distribution. A computer code has been developed for the conversion of an arbitrary activity distribution to a 3-D absorbed dose distribution. The activity distribution can be described either analytically or as a voxel based distribution, which comes from a SPECT acquisition. Decay points are sampled according to the activity map, and particles (photons and electrons) from the decay are followed through the tissue until they either escape the patient or drop below a cut off energy. To verify the calculated results, the mathematically defined MIRD phantom and unity density spheres have been included in the code. Also other published dosimetry data were used for verification. Absorbed fractions and S-values were calculated. A comparison with simulated data from the code with MIRD data shows good agreement. The S values are within 10-20% of published MIRD S values for most organs. Absorbed fractions for photons and electrons in spheres (masses between 1 g and 200 kg) are within 10-15% of those published. Radial absorbed dose distributions in a necrotic tumor show good agreement with published data. The application of the code in a radionuclide therapy dose planning system, based on quantitative SPECT, is discussed.},
  author       = {Tagesson, Magnus and Ljungberg, Michael and Strand, Sven-Erik},
  issn         = {1651-226X},
  language     = {eng},
  number       = {3},
  pages        = {367--372},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {A Monte-Carlo program converting activity distributions to absorbed dose distributions in a radionuclide treatment planning system},
  url          = {http://dx.doi.org/10.3109/02841869609101653},
  volume       = {35},
  year         = {1996},
}