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Parameters influencing volume and activity quantitation in SPECT

Sjörgreen, Katarina; Ljungberg, Michael LU and Strand, Sven-Erik LU (1996) In Acta Oncologica 35(3). p.323-330
Abstract
Several factors influence the accuracy to which information on the in vivo activity concentration can be obtained from SPECT images. The accuracy in image contrast and the quantitation of volume and activity has here been examined for a SPECT system aimed for absorbed dose determinations in systemic radiation therapy. The influence of source dimensions, object contrast, noise level, energy window width and the reconstruction filter was examined. All the investigated parameters affected the recoveries. Volumes of above 20 cm3 could be quantified to within +/- 20%, for object contrasts of above 96%, and within +/- 40% for object contrasts above 81%, providing limited levels of noise. Both the image contrast and the volume quantification is... (More)
Several factors influence the accuracy to which information on the in vivo activity concentration can be obtained from SPECT images. The accuracy in image contrast and the quantitation of volume and activity has here been examined for a SPECT system aimed for absorbed dose determinations in systemic radiation therapy. The influence of source dimensions, object contrast, noise level, energy window width and the reconstruction filter was examined. All the investigated parameters affected the recoveries. Volumes of above 20 cm3 could be quantified to within +/- 20%, for object contrasts of above 96%, and within +/- 40% for object contrasts above 81%, providing limited levels of noise. Both the image contrast and the volume quantification is expected to be improved in situations with low object contrasts, if accurate correction for scattered photons can be developed. Obtained limitations in the quantitation of activity with the present method should be reduced by development of a more accurate background subtraction technique. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
35
issue
3
pages
323 - 330
publisher
Taylor & Francis
external identifiers
  • pmid:8679264
  • scopus:0029941341
ISSN
1651-226X
DOI
10.3109/02841869609101649
language
English
LU publication?
yes
id
4da572d4-e56d-4313-8c12-030d83e90b30 (old id 1111135)
date added to LUP
2008-07-30 08:21:00
date last changed
2017-01-01 07:18:40
@article{4da572d4-e56d-4313-8c12-030d83e90b30,
  abstract     = {Several factors influence the accuracy to which information on the in vivo activity concentration can be obtained from SPECT images. The accuracy in image contrast and the quantitation of volume and activity has here been examined for a SPECT system aimed for absorbed dose determinations in systemic radiation therapy. The influence of source dimensions, object contrast, noise level, energy window width and the reconstruction filter was examined. All the investigated parameters affected the recoveries. Volumes of above 20 cm3 could be quantified to within +/- 20%, for object contrasts of above 96%, and within +/- 40% for object contrasts above 81%, providing limited levels of noise. Both the image contrast and the volume quantification is expected to be improved in situations with low object contrasts, if accurate correction for scattered photons can be developed. Obtained limitations in the quantitation of activity with the present method should be reduced by development of a more accurate background subtraction technique.},
  author       = {Sjörgreen, Katarina and Ljungberg, Michael and Strand, Sven-Erik},
  issn         = {1651-226X},
  language     = {eng},
  number       = {3},
  pages        = {323--330},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Parameters influencing volume and activity quantitation in SPECT},
  url          = {http://dx.doi.org/10.3109/02841869609101649},
  volume       = {35},
  year         = {1996},
}