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Pre-eclampsia is a potent risk factor for deterioration of retinopathy during pregnancy in Type 1 diabetic patients

Lövestam Adrian, Monica LU ; Agardh, Carl-David LU ; Åberg, Anders E LU and Agardh, Elisabet LU (1997) In Diabetic Medicine 14(12). p.1059-1065
Abstract
The aim of the present study was to examine the influence of pregnancy on deterioration of retinopathy in patients with Type 1 diabetes mellitus. Sixty-five pregnant Type 1 diabetic women attending the University Hospital in Lund were studied retrospectively. The degree of retinopathy, and levels of HbA1c and blood pressure 12 months before, during, and 6 months after pregnancy were compared of those of 56 non-pregnant Type 1 diabetic women matched for age and duration of diabetes. For all patients, sight-threatening deterioration of retinopathy did not differ between the pregnancy group (9/65) and the control group (6/56). Over time, pregnant patients had lower HbA1c levels than controls (p < 0.001). Pregnant patients with... (More)
The aim of the present study was to examine the influence of pregnancy on deterioration of retinopathy in patients with Type 1 diabetes mellitus. Sixty-five pregnant Type 1 diabetic women attending the University Hospital in Lund were studied retrospectively. The degree of retinopathy, and levels of HbA1c and blood pressure 12 months before, during, and 6 months after pregnancy were compared of those of 56 non-pregnant Type 1 diabetic women matched for age and duration of diabetes. For all patients, sight-threatening deterioration of retinopathy did not differ between the pregnancy group (9/65) and the control group (6/56). Over time, pregnant patients had lower HbA1c levels than controls (p < 0.001). Pregnant patients with sight-threatening deterioration of retinopathy had higher HbA1c levels than those without (p = 0.028 and the decrement in HbA1c between the 6-14th and the 20th week of gestation was more pronounced (p = 0.006). In those patients who developed pre-eclampsia during pregnancy, deterioration of retinopathy ocurred more frequently compared to those without pre-eclampsia (4/8 vs 5/65; p = 0.005). In conclusion, sight-threatening deterioration of retinopathy was not more common during pregnancy in IDDM patients than among age- and duration-matched control patients. In pregnant patients, deterioration of retinopathy was associated with the pregestational degree of metabolic control as well as with a rapidly improved glycaemic control acheived during pregnancy. Among those in whom deterioration occurred during pregnancy, pre-eclampsia was a potent risk factor. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pre-eclampsia, pregnancy, retinopathy, type 1 diabetes
in
Diabetic Medicine
volume
14
issue
12
pages
1059 - 1065
publisher
Wiley-Blackwell
external identifiers
  • pmid:9455934
  • scopus:0031455055
ISSN
1464-5491
DOI
10.1002/(SICI)1096-9136(199712)14:12<1059::AID-DIA505>3.0.CO;2-8
language
English
LU publication?
yes
id
1f9ee324-cb82-4a57-94d3-22d2d2da3c28 (old id 1111189)
date added to LUP
2008-07-16 17:01:22
date last changed
2017-01-01 06:45:44
@article{1f9ee324-cb82-4a57-94d3-22d2d2da3c28,
  abstract     = {The aim of the present study was to examine the influence of pregnancy on deterioration of retinopathy in patients with Type 1 diabetes mellitus. Sixty-five pregnant Type 1 diabetic women attending the University Hospital in Lund were studied retrospectively. The degree of retinopathy, and levels of HbA1c and blood pressure 12 months before, during, and 6 months after pregnancy were compared of those of 56 non-pregnant Type 1 diabetic women matched for age and duration of diabetes. For all patients, sight-threatening deterioration of retinopathy did not differ between the pregnancy group (9/65) and the control group (6/56). Over time, pregnant patients had lower HbA1c levels than controls (p &lt; 0.001). Pregnant patients with sight-threatening deterioration of retinopathy had higher HbA1c levels than those without (p = 0.028 and the decrement in HbA1c between the 6-14th and the 20th week of gestation was more pronounced (p = 0.006). In those patients who developed pre-eclampsia during pregnancy, deterioration of retinopathy ocurred more frequently compared to those without pre-eclampsia (4/8 vs 5/65; p = 0.005). In conclusion, sight-threatening deterioration of retinopathy was not more common during pregnancy in IDDM patients than among age- and duration-matched control patients. In pregnant patients, deterioration of retinopathy was associated with the pregestational degree of metabolic control as well as with a rapidly improved glycaemic control acheived during pregnancy. Among those in whom deterioration occurred during pregnancy, pre-eclampsia was a potent risk factor.},
  author       = {Lövestam Adrian, Monica and Agardh, Carl-David and Åberg, Anders E and Agardh, Elisabet},
  issn         = {1464-5491},
  keyword      = {pre-eclampsia,pregnancy,retinopathy,type 1 diabetes},
  language     = {eng},
  number       = {12},
  pages        = {1059--1065},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetic Medicine},
  title        = {Pre-eclampsia is a potent risk factor for deterioration of retinopathy during pregnancy in Type 1 diabetic patients},
  url          = {http://dx.doi.org/10.1002/(SICI)1096-9136(199712)14:12<1059::AID-DIA505>3.0.CO;2-8},
  volume       = {14},
  year         = {1997},
}