Advanced

Nitric oxide (NO) production in the upper airways is decreased in chronic sinusitis

Lindberg, Sven LU ; Cervin, Anders LU and Runer, Thomas (1997) In Acta Oto-Laryngologica 117(1). p.113-117
Abstract
The nasal concentration of nitric oxide (NO) was measured by chemiluminescence in healthy volunteers 3-68 years of age, and in patients suffering from common cold and chronic sinusitis. The concentration of NO in healthy subjects, 233.2 +/- 66.8 ppb (mean +/- SD), was found to be relatively independent of age and body size. The measured levels of NO did not differ between healthy volunteers and common cold patients, but they were significantly lower in patients suffering from chronic sinusitis, 96.4 +/- 72.8 ppb. As NO is a regulator of mucociliary activity and has bacteriostatic and antiviral effects, the decreased concentration of NO in patients suffering from sinusitis suggests that lack of NO may contribute to the pathogenesis of this... (More)
The nasal concentration of nitric oxide (NO) was measured by chemiluminescence in healthy volunteers 3-68 years of age, and in patients suffering from common cold and chronic sinusitis. The concentration of NO in healthy subjects, 233.2 +/- 66.8 ppb (mean +/- SD), was found to be relatively independent of age and body size. The measured levels of NO did not differ between healthy volunteers and common cold patients, but they were significantly lower in patients suffering from chronic sinusitis, 96.4 +/- 72.8 ppb. As NO is a regulator of mucociliary activity and has bacteriostatic and antiviral effects, the decreased concentration of NO in patients suffering from sinusitis suggests that lack of NO may contribute to the pathogenesis of this disease. The importance of NO for the mucociliary system was emphasized by the finding that the 2 patients with the lowest nasal concentration of NO were found to manifest functional and morphological changes of the mucociliary system that are typical of acquired mucociliary dysfunction. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cilia, mucociliary clearance, nitric oxide, sinusitis
in
Acta Oto-Laryngologica
volume
117
issue
1
pages
113 - 117
publisher
Taylor & Francis
external identifiers
  • pmid:9039491
  • scopus:0031046676
ISSN
1651-2251
DOI
10.3109/00016489709118001
language
English
LU publication?
yes
id
c4e64210-2ae0-4fb2-bb96-26967b209e3b (old id 1111616)
date added to LUP
2008-07-18 09:23:22
date last changed
2017-08-13 04:22:45
@article{c4e64210-2ae0-4fb2-bb96-26967b209e3b,
  abstract     = {The nasal concentration of nitric oxide (NO) was measured by chemiluminescence in healthy volunteers 3-68 years of age, and in patients suffering from common cold and chronic sinusitis. The concentration of NO in healthy subjects, 233.2 +/- 66.8 ppb (mean +/- SD), was found to be relatively independent of age and body size. The measured levels of NO did not differ between healthy volunteers and common cold patients, but they were significantly lower in patients suffering from chronic sinusitis, 96.4 +/- 72.8 ppb. As NO is a regulator of mucociliary activity and has bacteriostatic and antiviral effects, the decreased concentration of NO in patients suffering from sinusitis suggests that lack of NO may contribute to the pathogenesis of this disease. The importance of NO for the mucociliary system was emphasized by the finding that the 2 patients with the lowest nasal concentration of NO were found to manifest functional and morphological changes of the mucociliary system that are typical of acquired mucociliary dysfunction.},
  author       = {Lindberg, Sven and Cervin, Anders and Runer, Thomas},
  issn         = {1651-2251},
  keyword      = {cilia,mucociliary clearance,nitric oxide,sinusitis},
  language     = {eng},
  number       = {1},
  pages        = {113--117},
  publisher    = {Taylor & Francis},
  series       = {Acta Oto-Laryngologica},
  title        = {Nitric oxide (NO) production in the upper airways is decreased in chronic sinusitis},
  url          = {http://dx.doi.org/10.3109/00016489709118001},
  volume       = {117},
  year         = {1997},
}