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Clinical characteristics and biological parameters in temperamental clusters of suicide attempters

Engström, Gunnar LU ; Alling, Christer LU ; Gustavsson, P; Oreland, L and Träskman Bendz, Lil LU (1997) In Journal of Affective Disorders 44(1). p.45-55
Abstract
A sample of 215 suicide attempters was categorized in a cluster analysis into four groups according to temperamental trails. Monoamine metabolites in the cerebrospinal fluid were analysed (n = 106). Dexamethasone suppression tests (DST) were performed (n = 154) and the activity of the enzyme monoamine oxidase in platelets (pl-MAO) was assessed (n = 103). Patients belonging to the two clusters with the most deviant temperament profiles (nos 2 and 3) were young and scored high on the Beck Hopelessness Scale and the Suicide Assessment Scale. "Cluster 3" ("neurotic, impulsive, aggressive") patients often had dysthymia and axis II, cluster B diagnoses (e.g. borderline or histrionic personality). "Cluster 2" ("neurotic and introverted") patients... (More)
A sample of 215 suicide attempters was categorized in a cluster analysis into four groups according to temperamental trails. Monoamine metabolites in the cerebrospinal fluid were analysed (n = 106). Dexamethasone suppression tests (DST) were performed (n = 154) and the activity of the enzyme monoamine oxidase in platelets (pl-MAO) was assessed (n = 103). Patients belonging to the two clusters with the most deviant temperament profiles (nos 2 and 3) were young and scored high on the Beck Hopelessness Scale and the Suicide Assessment Scale. "Cluster 3" ("neurotic, impulsive, aggressive") patients often had dysthymia and axis II, cluster B diagnoses (e.g. borderline or histrionic personality). "Cluster 2" ("neurotic and introverted") patients often had major depression. The "Cluster 1", with on the whole a normal temperament profile, had significantly higher levels of post-DST cortisol than the other clusters. The "Cluster 4" had a normal temperament profile. Adjustment disorders were most common in "Cluster 1" and "Cluster 4". The monoamine metabolite levels did not differ between the clusters, and the differences in pl-MAO activity disappeared after adjusting for age and gender. The results suggest that temperament profiles in suicide attempters are related to psychiatric diagnoses, suicidality, hopelessness, and post-DST cortisol, but are not predictive of completed suicide. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Temperament, Suicide attempts, Depression, Monoamine metabolites, Monoamine oxidase, Dexamethasone
in
Journal of Affective Disorders
volume
44
issue
1
pages
45 - 55
publisher
Elsevier
external identifiers
  • pmid:9186802
  • scopus:0031004192
ISSN
1573-2517
DOI
10.1016/S0165-0327(97)00029-3
language
English
LU publication?
yes
id
06eb2fa9-5f66-4090-9a59-7b2bbdcad500 (old id 1111727)
date added to LUP
2008-07-18 11:23:52
date last changed
2017-01-01 04:49:35
@article{06eb2fa9-5f66-4090-9a59-7b2bbdcad500,
  abstract     = {A sample of 215 suicide attempters was categorized in a cluster analysis into four groups according to temperamental trails. Monoamine metabolites in the cerebrospinal fluid were analysed (n = 106). Dexamethasone suppression tests (DST) were performed (n = 154) and the activity of the enzyme monoamine oxidase in platelets (pl-MAO) was assessed (n = 103). Patients belonging to the two clusters with the most deviant temperament profiles (nos 2 and 3) were young and scored high on the Beck Hopelessness Scale and the Suicide Assessment Scale. "Cluster 3" ("neurotic, impulsive, aggressive") patients often had dysthymia and axis II, cluster B diagnoses (e.g. borderline or histrionic personality). "Cluster 2" ("neurotic and introverted") patients often had major depression. The "Cluster 1", with on the whole a normal temperament profile, had significantly higher levels of post-DST cortisol than the other clusters. The "Cluster 4" had a normal temperament profile. Adjustment disorders were most common in "Cluster 1" and "Cluster 4". The monoamine metabolite levels did not differ between the clusters, and the differences in pl-MAO activity disappeared after adjusting for age and gender. The results suggest that temperament profiles in suicide attempters are related to psychiatric diagnoses, suicidality, hopelessness, and post-DST cortisol, but are not predictive of completed suicide.},
  author       = {Engström, Gunnar and Alling, Christer and Gustavsson, P and Oreland, L and Träskman Bendz, Lil},
  issn         = {1573-2517},
  keyword      = {Temperament,Suicide attempts,Depression,Monoamine metabolites,Monoamine oxidase,Dexamethasone},
  language     = {eng},
  number       = {1},
  pages        = {45--55},
  publisher    = {Elsevier},
  series       = {Journal of Affective Disorders},
  title        = {Clinical characteristics and biological parameters in temperamental clusters of suicide attempters},
  url          = {http://dx.doi.org/10.1016/S0165-0327(97)00029-3},
  volume       = {44},
  year         = {1997},
}