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Effect of intensive training on lower leg structural strength: an in vivo study in ovariectomized rats

Kaastad, T S; Reikeras, O; Narum, S; Madsen, J E; Haug, E; Obrant, Karl LU and Nordsletten, L (1997) In Scandinavian Journal of Medicine & Science in Sports 7(4). p.220-225
Abstract
The aim of this study was to investigate the effect of training on the in vivo tibial structural strength during the development of post-ovariectomy osteoporosis. Seventeen mature Wistar rats (215 g) were ovariectomized and randomized into two groups. The sedentary control group was kept cage confined, while 3 days postoperatively the trained group started treadmill running with high intensity for 1 h 5 days a week. All were given a low calcium diet (Ca 0.01%). After 8 weeks the animals were anaesthetized and the right lower legs fractured during muscle contraction in three-point ventral bending. The left legs were fractured at the same level after removal of all soft tissues. Histomorphometry of the meta- and diaphysis of the distal... (More)
The aim of this study was to investigate the effect of training on the in vivo tibial structural strength during the development of post-ovariectomy osteoporosis. Seventeen mature Wistar rats (215 g) were ovariectomized and randomized into two groups. The sedentary control group was kept cage confined, while 3 days postoperatively the trained group started treadmill running with high intensity for 1 h 5 days a week. All were given a low calcium diet (Ca 0.01%). After 8 weeks the animals were anaesthetized and the right lower legs fractured during muscle contraction in three-point ventral bending. The left legs were fractured at the same level after removal of all soft tissues. Histomorphometry of the meta- and diaphysis of the distal tibiae was performed. Weight-gain was higher in sedentary (108 g) than in trained (61 g) rats (P<0.0001). There were no significant differences in mechanical results between the groups at in vivo or in vitro fracture. Correcting for weight-gain differences did not change these results. Histomorphometry showed no differences between the groups. Corticosterone was higher in trained than in sedentary rats (P<0.02), and corticosterone may have had a negative influence both on muscle and bone. The study could not show an effect of high intensity training in the early phase after ovariectomy on in vivo or in vitro fracture strength. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
exercise, muscle contraction, fractures, osteoporosis, corticosterone, rats
in
Scandinavian Journal of Medicine & Science in Sports
volume
7
issue
4
pages
220 - 225
publisher
Wiley-Blackwell
external identifiers
  • pmid:9241027
  • scopus:0031201991
ISSN
1600-0838
DOI
10.1111/j.1600-0838.1997.tb00143.x
language
English
LU publication?
yes
id
918afebd-8468-4902-8b31-f8f12aec459a (old id 1111812)
alternative location
http://www3.interscience.wiley.com/cgi-bin/fulltext/119174536/PDFSTART
date added to LUP
2008-07-18 13:45:15
date last changed
2017-01-01 06:48:35
@article{918afebd-8468-4902-8b31-f8f12aec459a,
  abstract     = {The aim of this study was to investigate the effect of training on the in vivo tibial structural strength during the development of post-ovariectomy osteoporosis. Seventeen mature Wistar rats (215 g) were ovariectomized and randomized into two groups. The sedentary control group was kept cage confined, while 3 days postoperatively the trained group started treadmill running with high intensity for 1 h 5 days a week. All were given a low calcium diet (Ca 0.01%). After 8 weeks the animals were anaesthetized and the right lower legs fractured during muscle contraction in three-point ventral bending. The left legs were fractured at the same level after removal of all soft tissues. Histomorphometry of the meta- and diaphysis of the distal tibiae was performed. Weight-gain was higher in sedentary (108 g) than in trained (61 g) rats (P&lt;0.0001). There were no significant differences in mechanical results between the groups at in vivo or in vitro fracture. Correcting for weight-gain differences did not change these results. Histomorphometry showed no differences between the groups. Corticosterone was higher in trained than in sedentary rats (P&lt;0.02), and corticosterone may have had a negative influence both on muscle and bone. The study could not show an effect of high intensity training in the early phase after ovariectomy on in vivo or in vitro fracture strength.},
  author       = {Kaastad, T S and Reikeras, O and Narum, S and Madsen, J E and Haug, E and Obrant, Karl and Nordsletten, L},
  issn         = {1600-0838},
  keyword      = {exercise,muscle contraction,fractures,osteoporosis,corticosterone,rats},
  language     = {eng},
  number       = {4},
  pages        = {220--225},
  publisher    = {Wiley-Blackwell},
  series       = {Scandinavian Journal of Medicine & Science in Sports},
  title        = {Effect of intensive training on lower leg structural strength: an in vivo study in ovariectomized rats},
  url          = {http://dx.doi.org/10.1111/j.1600-0838.1997.tb00143.x},
  volume       = {7},
  year         = {1997},
}