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Selection of collimator for rCBF studies and evaluation of triple-headed SPET using noise-resolution plots

Ärlig, A ; Jacobsson, L ; Larsson, A ; Ljungberg, Michael LU and Wikkelso, C (1997) In Nuclear Medicine Communications 18(7). p.655-661
Abstract
We investigated the effect of collimator selection on image quality in regional cerebral blood flow (rCBF) studies of the brain performed with 99Tc(m)-HMPAO. A triple-headed SPET system (GE/CGR Neurocam) was used, together with three sets of parallel-hole collimators - general-purpose (GP), high-resolution (HR) and ultra-high-resolution (UHR). Two image quality parameters were used to describe the image quality, namely, noise and resolution. Noise was measured in experimental and Monte-Carlo simulated SPET studies of a cylinder phantom of uniform activity as the pixel root mean square error (RMS) and as the coefficient of variation (CV) of quantitative rCBF values. Resolution was measured as full-width at half-maximum in experimental SPET... (More)
We investigated the effect of collimator selection on image quality in regional cerebral blood flow (rCBF) studies of the brain performed with 99Tc(m)-HMPAO. A triple-headed SPET system (GE/CGR Neurocam) was used, together with three sets of parallel-hole collimators - general-purpose (GP), high-resolution (HR) and ultra-high-resolution (UHR). Two image quality parameters were used to describe the image quality, namely, noise and resolution. Noise was measured in experimental and Monte-Carlo simulated SPET studies of a cylinder phantom of uniform activity as the pixel root mean square error (RMS) and as the coefficient of variation (CV) of quantitative rCBF values. Resolution was measured as full-width at half-maximum in experimental SPET studies of a line-source. Plots of noise versus resolution for the different collimators were obtained by varying the cut-off frequency of the Hanning filter applied in the reconstruction of transaxial slices. From these noise-resolution plots, we were able to determine which collimator gave the best resolution for a specific noise level. A lowest reasonable noise level may be established by comparison with the inter-observer CV of the quantification method. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nuclear Medicine Communications
volume
18
issue
7
pages
655 - 661
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:9342104
  • scopus:0030761579
ISSN
1473-5628
language
English
LU publication?
yes
id
f6bb4898-6a41-49d8-9bf4-d572f81fd2d2 (old id 1111891)
date added to LUP
2016-04-01 11:42:40
date last changed
2022-01-26 17:06:28
@article{f6bb4898-6a41-49d8-9bf4-d572f81fd2d2,
  abstract     = {{We investigated the effect of collimator selection on image quality in regional cerebral blood flow (rCBF) studies of the brain performed with 99Tc(m)-HMPAO. A triple-headed SPET system (GE/CGR Neurocam) was used, together with three sets of parallel-hole collimators - general-purpose (GP), high-resolution (HR) and ultra-high-resolution (UHR). Two image quality parameters were used to describe the image quality, namely, noise and resolution. Noise was measured in experimental and Monte-Carlo simulated SPET studies of a cylinder phantom of uniform activity as the pixel root mean square error (RMS) and as the coefficient of variation (CV) of quantitative rCBF values. Resolution was measured as full-width at half-maximum in experimental SPET studies of a line-source. Plots of noise versus resolution for the different collimators were obtained by varying the cut-off frequency of the Hanning filter applied in the reconstruction of transaxial slices. From these noise-resolution plots, we were able to determine which collimator gave the best resolution for a specific noise level. A lowest reasonable noise level may be established by comparison with the inter-observer CV of the quantification method.}},
  author       = {{Ärlig, A and Jacobsson, L and Larsson, A and Ljungberg, Michael and Wikkelso, C}},
  issn         = {{1473-5628}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{655--661}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Nuclear Medicine Communications}},
  title        = {{Selection of collimator for rCBF studies and evaluation of triple-headed SPET using noise-resolution plots}},
  volume       = {{18}},
  year         = {{1997}},
}