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Experimental human exposure to N,N-dimethylbenzylamine: generation of a controlled atmosphere and biological monitoring

Ståhlbom, Bengt; Åkesson, Bengt LU and Jönsson, Bo A LU (1997) In International Archives of Occupational and Environmental Health 70(6). p.393-398
Abstract
The aim of the present study was to develop a method for generation of dimethylbenzylamine (DMBA) atmospheres in an exposure chamber and to investigate the possibility of using urinary DMBA metabolites for biological monitoring of exposure to DMBA. A DMBA atmosphere was generated by use of the gas-permeation principle. Six healthy male volunteers were exposed for 8 h to DMBA at air levels of 20, 45, and 80 μm/m3. Air levels of DMBA were analyzed by gas chromatography (GC). The total urinary amount of DMBA (U-SumDMBA; DMBA and metabolites that can be reduced to DMBA, e.g., DMBAO) was analyzed using GC-mass spectrometry (MS). The exposure chamber maintained very low (0–130 μg/m3) and steady concentrations for several weeks. DMBA uptake by... (More)
The aim of the present study was to develop a method for generation of dimethylbenzylamine (DMBA) atmospheres in an exposure chamber and to investigate the possibility of using urinary DMBA metabolites for biological monitoring of exposure to DMBA. A DMBA atmosphere was generated by use of the gas-permeation principle. Six healthy male volunteers were exposed for 8 h to DMBA at air levels of 20, 45, and 80 μm/m3. Air levels of DMBA were analyzed by gas chromatography (GC). The total urinary amount of DMBA (U-SumDMBA; DMBA and metabolites that can be reduced to DMBA, e.g., DMBAO) was analyzed using GC-mass spectrometry (MS). The exposure chamber maintained very low (0–130 μg/m3) and steady concentrations for several weeks. DMBA uptake by inhalation was 76%. The amine was quickly distributed and biotransformed to nearly 100%. DMBA was eliminated in the urine with a half-time of 4.3 h. More than 50% was eliminated within 2 h of exposure. However, at all exposure levels the subjects continued to excrete DMBA the next morning. There was a significant correlation between the exposure to DMBA and the U-SumDMBA. Thus, U-SumDMBA may become an important biomarker for monitoring of industrial exposure to DMBA. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Epoxy resin, N, N-Dimethylbenzylamine, Urinary excretion, Biological monitoring
in
International Archives of Occupational and Environmental Health
volume
70
issue
6
pages
393 - 398
publisher
Springer
external identifiers
  • scopus:0030817360
ISSN
1432-1246
DOI
10.1007/s004200050234
language
English
LU publication?
yes
id
ef2f56c0-ab04-4ce0-b43a-97be8c3dc316 (old id 1111902)
date added to LUP
2008-07-18 15:59:19
date last changed
2017-01-01 07:00:24
@article{ef2f56c0-ab04-4ce0-b43a-97be8c3dc316,
  abstract     = {The aim of the present study was to develop a method for generation of dimethylbenzylamine (DMBA) atmospheres in an exposure chamber and to investigate the possibility of using urinary DMBA metabolites for biological monitoring of exposure to DMBA. A DMBA atmosphere was generated by use of the gas-permeation principle. Six healthy male volunteers were exposed for 8 h to DMBA at air levels of 20, 45, and 80 μm/m3. Air levels of DMBA were analyzed by gas chromatography (GC). The total urinary amount of DMBA (U-SumDMBA; DMBA and metabolites that can be reduced to DMBA, e.g., DMBAO) was analyzed using GC-mass spectrometry (MS). The exposure chamber maintained very low (0–130 μg/m3) and steady concentrations for several weeks. DMBA uptake by inhalation was 76%. The amine was quickly distributed and biotransformed to nearly 100%. DMBA was eliminated in the urine with a half-time of 4.3 h. More than 50% was eliminated within 2 h of exposure. However, at all exposure levels the subjects continued to excrete DMBA the next morning. There was a significant correlation between the exposure to DMBA and the U-SumDMBA. Thus, U-SumDMBA may become an important biomarker for monitoring of industrial exposure to DMBA.},
  author       = {Ståhlbom, Bengt and Åkesson, Bengt and Jönsson, Bo A},
  issn         = {1432-1246},
  keyword      = {Epoxy resin,N,N-Dimethylbenzylamine,Urinary excretion,Biological monitoring},
  language     = {eng},
  number       = {6},
  pages        = {393--398},
  publisher    = {Springer},
  series       = {International Archives of Occupational and Environmental Health},
  title        = {Experimental human exposure to N,N-dimethylbenzylamine: generation of a controlled atmosphere and biological monitoring},
  url          = {http://dx.doi.org/10.1007/s004200050234},
  volume       = {70},
  year         = {1997},
}