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Minor components with smooth muscle relaxing properties from scented myrrh (Commiphora guidotti)

Andersson, Maria; Bergendorff, Ola LU ; Shan, Rudong; Zygmunt, Peter LU and Sterner, Olov LU (1997) In Planta Medica 63(3). p.251-254
Abstract
All sesquiterpenes present in a sample of scented myrrh were isolated and characterised. Seven compounds, with cadinane, guaiane, oplopane, and eudesmane skeletons, were obtained, of which two are new and two are reported from a natural source for the first time. The major component, T-cadinol, has previously been shown to possess smooth muscle-relaxing properties, and the major purpose of the investigation was to compare the effects of the minor and more polar sesquiterpenes with that of T-cadinol in the rat aorta. Like T-cadinol, the minor sesquiterpenes are more efficient in reducing K(+)-induced contractions than those induced by the alpha-adrenoceptor agonist phenylephrine, however, they were all less potent than T-cadinol.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Scented myrrh, Commiphora guidotti, Burseraceae, sesquiterpenes, T-cadinol, smooth muscle relaxant
in
Planta Medica
volume
63
issue
3
pages
251 - 254
publisher
Georg Thieme Verlag
external identifiers
  • pmid:9225607
  • scopus:0031157055
ISSN
0032-0943
DOI
10.1055/s-2006-957665
language
English
LU publication?
yes
id
1723c7ce-7253-413c-b6b4-3a6357db1ad4 (old id 1111941)
date added to LUP
2008-07-21 10:40:56
date last changed
2017-05-21 03:41:57
@article{1723c7ce-7253-413c-b6b4-3a6357db1ad4,
  abstract     = {All sesquiterpenes present in a sample of scented myrrh were isolated and characterised. Seven compounds, with cadinane, guaiane, oplopane, and eudesmane skeletons, were obtained, of which two are new and two are reported from a natural source for the first time. The major component, T-cadinol, has previously been shown to possess smooth muscle-relaxing properties, and the major purpose of the investigation was to compare the effects of the minor and more polar sesquiterpenes with that of T-cadinol in the rat aorta. Like T-cadinol, the minor sesquiterpenes are more efficient in reducing K(+)-induced contractions than those induced by the alpha-adrenoceptor agonist phenylephrine, however, they were all less potent than T-cadinol.},
  author       = {Andersson, Maria and Bergendorff, Ola and Shan, Rudong and Zygmunt, Peter and Sterner, Olov},
  issn         = {0032-0943},
  keyword      = {Scented myrrh,Commiphora guidotti,Burseraceae,sesquiterpenes,T-cadinol,smooth muscle relaxant},
  language     = {eng},
  number       = {3},
  pages        = {251--254},
  publisher    = {Georg Thieme Verlag},
  series       = {Planta Medica},
  title        = {Minor components with smooth muscle relaxing properties from scented myrrh (Commiphora guidotti)},
  url          = {http://dx.doi.org/10.1055/s-2006-957665},
  volume       = {63},
  year         = {1997},
}