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Furanocoumarins with affinity to brain benzodiazepine receptors in vitro

Bergendorff, Ola LU ; Dekermendjian, Kim ; Nielsen, Mogens ; Shan, Rudong ; Witt, Robin ; Ai, Jinglu and Sterner, Olov LU (1997) In Phytochemistry 44(6). p.1121-1124
Abstract
Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Phytochemistry
volume
44
issue
6
pages
1121 - 1124
publisher
Elsevier
external identifiers
  • pmid:9055449
  • scopus:0031106566
ISSN
0031-9422
DOI
10.1016/S0031-9422(96)00703-0
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Dermatology and Venereology (Lund) (013006000), Organic chemistry (S/LTH) (011001240)
id
51d63fe0-575d-48d9-aed5-77bac9c4232c (old id 1111949)
date added to LUP
2016-04-01 16:33:46
date last changed
2020-09-09 03:34:38
@article{51d63fe0-575d-48d9-aed5-77bac9c4232c,
  abstract     = {Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.},
  author       = {Bergendorff, Ola and Dekermendjian, Kim and Nielsen, Mogens and Shan, Rudong and Witt, Robin and Ai, Jinglu and Sterner, Olov},
  issn         = {0031-9422},
  language     = {eng},
  number       = {6},
  pages        = {1121--1124},
  publisher    = {Elsevier},
  series       = {Phytochemistry},
  title        = {Furanocoumarins with affinity to brain benzodiazepine receptors in vitro},
  url          = {http://dx.doi.org/10.1016/S0031-9422(96)00703-0},
  doi          = {10.1016/S0031-9422(96)00703-0},
  volume       = {44},
  year         = {1997},
}