S-100beta stimulates neurite outgrowth in the rat sciatic nerve grafted with acellular muscle transplants
(1997) In Brain Research 753(2). p.196-201- Abstract
- S-100beta promotes neurite extension in vitro and motoneuron survival in the chicken embryo. We demonstrate here that local administration of S-100beta stimulates the sciatic nerve regeneration into acellular muscle grafts. Normally there is a 8-10 day delay in the regeneration of axons into such grafts. Local administration of S-100beta (0.5-1.0 microg/h) significantly stimulated regeneration into the grafts. In S-100beta treated grafts, the regeneration distance was increased with a factor of about 2.3 times as compared to vehicle treated grafts. The distance of regeneration was monitored with pinch test which detects sensory axons. Regenerating axons were growing outside the necrotic muscle cells as revealed with immunohistochemistry... (More)
- S-100beta promotes neurite extension in vitro and motoneuron survival in the chicken embryo. We demonstrate here that local administration of S-100beta stimulates the sciatic nerve regeneration into acellular muscle grafts. Normally there is a 8-10 day delay in the regeneration of axons into such grafts. Local administration of S-100beta (0.5-1.0 microg/h) significantly stimulated regeneration into the grafts. In S-100beta treated grafts, the regeneration distance was increased with a factor of about 2.3 times as compared to vehicle treated grafts. The distance of regeneration was monitored with pinch test which detects sensory axons. Regenerating axons were growing outside the necrotic muscle cells as revealed with immunohistochemistry for the neurofilament light weight polypeptide. S-100beta was demonstrated immunocytochemically in motor neurons of the rat lumbar spinal cord and in large and medium sized neurons of the dorsal root ganglia. The results suggest that S-100beta is a physiological growth factor for peripheral nerve axons. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1111979
- author
- Haglid, Kenneth G ; Yang, Qiner ; Hamberger, Anders ; Bergman, Stina ; Widerberg, Annika LU and Danielsen, Nils LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Axotomy, Nerve regeneration, Neurotrophic effect, Sensory test
- in
- Brain Research
- volume
- 753
- issue
- 2
- pages
- 196 - 201
- publisher
- Elsevier
- external identifiers
-
- pmid:9125403
- scopus:0031564528
- ISSN
- 1872-6240
- DOI
- 10.1016/S0006-8993(96)01463-1
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Reconstructive Surgery (013240300), Neural Interfaces (013212003)
- id
- e46bfeed-749c-41d7-91ba-a0454f2141ac (old id 1111979)
- date added to LUP
- 2016-04-01 12:16:18
- date last changed
- 2022-04-21 05:09:38
@article{e46bfeed-749c-41d7-91ba-a0454f2141ac, abstract = {{S-100beta promotes neurite extension in vitro and motoneuron survival in the chicken embryo. We demonstrate here that local administration of S-100beta stimulates the sciatic nerve regeneration into acellular muscle grafts. Normally there is a 8-10 day delay in the regeneration of axons into such grafts. Local administration of S-100beta (0.5-1.0 microg/h) significantly stimulated regeneration into the grafts. In S-100beta treated grafts, the regeneration distance was increased with a factor of about 2.3 times as compared to vehicle treated grafts. The distance of regeneration was monitored with pinch test which detects sensory axons. Regenerating axons were growing outside the necrotic muscle cells as revealed with immunohistochemistry for the neurofilament light weight polypeptide. S-100beta was demonstrated immunocytochemically in motor neurons of the rat lumbar spinal cord and in large and medium sized neurons of the dorsal root ganglia. The results suggest that S-100beta is a physiological growth factor for peripheral nerve axons.}}, author = {{Haglid, Kenneth G and Yang, Qiner and Hamberger, Anders and Bergman, Stina and Widerberg, Annika and Danielsen, Nils}}, issn = {{1872-6240}}, keywords = {{Axotomy; Nerve regeneration; Neurotrophic effect; Sensory test}}, language = {{eng}}, number = {{2}}, pages = {{196--201}}, publisher = {{Elsevier}}, series = {{Brain Research}}, title = {{S-100beta stimulates neurite outgrowth in the rat sciatic nerve grafted with acellular muscle transplants}}, url = {{http://dx.doi.org/10.1016/S0006-8993(96)01463-1}}, doi = {{10.1016/S0006-8993(96)01463-1}}, volume = {{753}}, year = {{1997}}, }