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Total parenteral nutrition influences both endocrine and exocrine function of rat pancreas

Fan, Bo-Guang; Salehi, S Albert LU ; Sternby, Berit LU ; Axelson, Jan LU ; Lundquist, Ingmar LU ; Andren-Sandberg, Åke and Ekelund, Mats LU (1997) In Pancreas 15(2). p.147-153
Abstract
The aim of this study was to examine the effect of total parenteral nutrition (TPN) on the endocrine and exocine function of the pancreas. Endocrine function was investigated using an intravenous glucose tolerance test (IGTT) in rats with TPN for 7 or 14 days. Exocrine function was evaluated by measuring amylase secretion from isolated acini as well as pancreatic weight, water content, protein, and enzymes after 7 days of TPN. When the TPN rats were compared with the controls, the glucose tolerance curve after an IGTT was unchanged, the basal plasma insulin levels were slightly lower and the insulin secretory response to intravenous glucose was markedly impaired. No differences could be seen between the insulin response after 7 days and... (More)
The aim of this study was to examine the effect of total parenteral nutrition (TPN) on the endocrine and exocine function of the pancreas. Endocrine function was investigated using an intravenous glucose tolerance test (IGTT) in rats with TPN for 7 or 14 days. Exocrine function was evaluated by measuring amylase secretion from isolated acini as well as pancreatic weight, water content, protein, and enzymes after 7 days of TPN. When the TPN rats were compared with the controls, the glucose tolerance curve after an IGTT was unchanged, the basal plasma insulin levels were slightly lower and the insulin secretory response to intravenous glucose was markedly impaired. No differences could be seen between the insulin response after 7 days and that after 14 days of TPN. The weight of pancreas, the total content and concentration of pancreatic protein, and the total amylase content of the pancreas were lower, whereas the total content of both chymotrypsin and trypsin was higher. The concentration of DNA remained intact, whereas the total DNA content decreased. The levels of lipolytic enzymes, except for carboxylesterlipase, were unaffected. After TPN treatment, the insulin secretory response to glucose is impaired, the exocrine pancreas is hypoplastic and the storage pattern of pancreatic exocrine enzymes is altered. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pancreas
volume
15
issue
2
pages
147 - 153
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:9260199
  • scopus:0030782734
ISSN
0885-3177
language
English
LU publication?
yes
id
9217e1a3-0006-4454-9c56-eca115ea1792 (old id 1112089)
date added to LUP
2008-07-21 12:38:21
date last changed
2017-05-14 03:35:28
@article{9217e1a3-0006-4454-9c56-eca115ea1792,
  abstract     = {The aim of this study was to examine the effect of total parenteral nutrition (TPN) on the endocrine and exocine function of the pancreas. Endocrine function was investigated using an intravenous glucose tolerance test (IGTT) in rats with TPN for 7 or 14 days. Exocrine function was evaluated by measuring amylase secretion from isolated acini as well as pancreatic weight, water content, protein, and enzymes after 7 days of TPN. When the TPN rats were compared with the controls, the glucose tolerance curve after an IGTT was unchanged, the basal plasma insulin levels were slightly lower and the insulin secretory response to intravenous glucose was markedly impaired. No differences could be seen between the insulin response after 7 days and that after 14 days of TPN. The weight of pancreas, the total content and concentration of pancreatic protein, and the total amylase content of the pancreas were lower, whereas the total content of both chymotrypsin and trypsin was higher. The concentration of DNA remained intact, whereas the total DNA content decreased. The levels of lipolytic enzymes, except for carboxylesterlipase, were unaffected. After TPN treatment, the insulin secretory response to glucose is impaired, the exocrine pancreas is hypoplastic and the storage pattern of pancreatic exocrine enzymes is altered.},
  author       = {Fan, Bo-Guang and Salehi, S Albert and Sternby, Berit and Axelson, Jan and Lundquist, Ingmar and Andren-Sandberg, Åke and Ekelund, Mats},
  issn         = {0885-3177},
  language     = {eng},
  number       = {2},
  pages        = {147--153},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Pancreas},
  title        = {Total parenteral nutrition influences both endocrine and exocrine function of rat pancreas},
  volume       = {15},
  year         = {1997},
}