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Contradictory effects of dopamine at 32 degrees C in pigs anesthetized with ketamine

Roscher, Roger LU ; Ingemansson, Richard LU ; Wetterberg, T; Algotsson, Lars LU ; Sjöberg, Trygve LU and Steen, Stig LU (1997) In Acta Anaesthesiologica Scandinavica 41(9). p.1213-1217
Abstract
BACKGROUND: In critically ill patients who were surface cooled to 33 +/- 2 degrees C, we have observed that dopamine sometimes causes a substantial decrease in blood pressure. The present study was designed to compare the effects of dopamine in normothermia to those seen after surface cooling to 32 degrees C. METHODS: Seven pigs with a mean body weight of 21 kg were anesthetized with ketamine and muscle relaxation was induced with pancuronium. They were mechanically ventilated and given dopamine infusions (5 and 12 micrograms.kg-1.min-1)in normothermia and after surface cooling by cold water immersion to a central blood temperature of 32.0 degrees C (range 31.6-32.6 degrees C). RESULTS: In normothermia, dopamine at a dose of 5... (More)
BACKGROUND: In critically ill patients who were surface cooled to 33 +/- 2 degrees C, we have observed that dopamine sometimes causes a substantial decrease in blood pressure. The present study was designed to compare the effects of dopamine in normothermia to those seen after surface cooling to 32 degrees C. METHODS: Seven pigs with a mean body weight of 21 kg were anesthetized with ketamine and muscle relaxation was induced with pancuronium. They were mechanically ventilated and given dopamine infusions (5 and 12 micrograms.kg-1.min-1)in normothermia and after surface cooling by cold water immersion to a central blood temperature of 32.0 degrees C (range 31.6-32.6 degrees C). RESULTS: In normothermia, dopamine at a dose of 5 micrograms.kg-1.min-1 increased mean arterial blood pressure (MAP) by 16% (P < 0.01) and cardiac output (CO) by 9% (P = 0.051); at 12 micrograms.kg-1.min-1 dopamine increased MAP by 26% (P < 0.01) and CO by 18% (P < 0.01). In hypothermia, MAP and CO did not change at an administration rate of 5 micrograms.kg-1.min-1; at 12 micrograms.kg-1.min-1 CO was unchanged but MAP was significantly reduced by 15% (P < 0.01). CONCLUSION: Dopamine increased CO and MAP in normothermia but not at 32 degrees C, where there was even a significant reduction of MAP in this porcine model. (Less)
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Contribution to journal
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published
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keywords
Ketamine, General anesthesia, Induced hypothermia, Intravenous administration, Dopamine, Cardiotonic agent, Hemodynamics, Blood pressure, Blood flow, Heart, Systolic volume, Pig, Animal, Artiodactyla, Ungulata, Mammalia, Vertebrata
in
Acta Anaesthesiologica Scandinavica
volume
41
issue
9
pages
1213 - 1217
publisher
Wiley-Blackwell
external identifiers
  • pmid:9366946
ISSN
0001-5172
language
English
LU publication?
yes
id
7f3b9327-1395-4cec-a63d-340d0dd55d3d (old id 1112237)
date added to LUP
2008-07-21 16:22:54
date last changed
2016-04-15 20:37:31
@article{7f3b9327-1395-4cec-a63d-340d0dd55d3d,
  abstract     = {BACKGROUND: In critically ill patients who were surface cooled to 33 +/- 2 degrees C, we have observed that dopamine sometimes causes a substantial decrease in blood pressure. The present study was designed to compare the effects of dopamine in normothermia to those seen after surface cooling to 32 degrees C. METHODS: Seven pigs with a mean body weight of 21 kg were anesthetized with ketamine and muscle relaxation was induced with pancuronium. They were mechanically ventilated and given dopamine infusions (5 and 12 micrograms.kg-1.min-1)in normothermia and after surface cooling by cold water immersion to a central blood temperature of 32.0 degrees C (range 31.6-32.6 degrees C). RESULTS: In normothermia, dopamine at a dose of 5 micrograms.kg-1.min-1 increased mean arterial blood pressure (MAP) by 16% (P &lt; 0.01) and cardiac output (CO) by 9% (P = 0.051); at 12 micrograms.kg-1.min-1 dopamine increased MAP by 26% (P &lt; 0.01) and CO by 18% (P &lt; 0.01). In hypothermia, MAP and CO did not change at an administration rate of 5 micrograms.kg-1.min-1; at 12 micrograms.kg-1.min-1 CO was unchanged but MAP was significantly reduced by 15% (P &lt; 0.01). CONCLUSION: Dopamine increased CO and MAP in normothermia but not at 32 degrees C, where there was even a significant reduction of MAP in this porcine model.},
  author       = {Roscher, Roger and Ingemansson, Richard and Wetterberg, T and Algotsson, Lars and Sjöberg, Trygve and Steen, Stig},
  issn         = {0001-5172},
  keyword      = {Ketamine,General anesthesia,Induced hypothermia,Intravenous administration,Dopamine,Cardiotonic agent,Hemodynamics,Blood pressure,Blood flow,Heart,Systolic volume,Pig,Animal,Artiodactyla,Ungulata,Mammalia,Vertebrata},
  language     = {eng},
  number       = {9},
  pages        = {1213--1217},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Anaesthesiologica Scandinavica},
  title        = {Contradictory effects of dopamine at 32 degrees C in pigs anesthetized with ketamine},
  volume       = {41},
  year         = {1997},
}