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Review Article: Osteoporosis - an update

Samsioe, Göran LU (1997) In Acta Obstetricia et Gynecologica Scandinavica 76(3). p.189-199
Abstract
Osteoporosis and subsequent fractures is a rapidly growing major health problem in many parts of the world. Even if prevalence and incidence are high in Europe, rate of increase is even higher in Asia. The majority of fractures occur in women underlining the importance of ovarian deficiency. Genetic factors and lifestyle greatly influence the incidence and prevalence both in men and women and the importance of estrogen deficiency at ages over 85, where a large number of fractures actually occur, may well be questioned. Among several risk factors the amount of bone mass remains crucial. Several techniques adequate in accuracy and precision exist to determine bone mass. The costs for these measurements are not negligible. Several... (More)
Osteoporosis and subsequent fractures is a rapidly growing major health problem in many parts of the world. Even if prevalence and incidence are high in Europe, rate of increase is even higher in Asia. The majority of fractures occur in women underlining the importance of ovarian deficiency. Genetic factors and lifestyle greatly influence the incidence and prevalence both in men and women and the importance of estrogen deficiency at ages over 85, where a large number of fractures actually occur, may well be questioned. Among several risk factors the amount of bone mass remains crucial. Several techniques adequate in accuracy and precision exist to determine bone mass. The costs for these measurements are not negligible. Several pharmacologic regimens look promising for the prevention of osteoporosis and indeed for treatment of established osteoporosis. However, long-term data and clinical experience are warranted prior to establishing these pharmacological tools in the field of osteoporosis. For HRT and ERT such data are available. ERT and indeed HRT may halve the risk of osteoporotic fractures in women at least in current users. The effect at least on bone mass wears off after discontinuation of treatment but is never totally lost. In the interest of health care costs it is suggested that HRT could be started 15-20 years after the menopause and still provide protection for subsequent fractures. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bone fragility, bone fracture, bone loss, bone mineral density, osteoporosis
in
Acta Obstetricia et Gynecologica Scandinavica
volume
76
issue
3
pages
189 - 199
publisher
Wiley-Blackwell
external identifiers
  • pmid:9093130
ISSN
1600-0412
DOI
10.3109/00016349709048140
language
English
LU publication?
yes
id
30d1d624-f3cf-4af9-b949-10c170588e7e (old id 1112367)
date added to LUP
2008-07-22 10:16:08
date last changed
2016-09-30 05:48:21
@article{30d1d624-f3cf-4af9-b949-10c170588e7e,
  abstract     = {Osteoporosis and subsequent fractures is a rapidly growing major health problem in many parts of the world. Even if prevalence and incidence are high in Europe, rate of increase is even higher in Asia. The majority of fractures occur in women underlining the importance of ovarian deficiency. Genetic factors and lifestyle greatly influence the incidence and prevalence both in men and women and the importance of estrogen deficiency at ages over 85, where a large number of fractures actually occur, may well be questioned. Among several risk factors the amount of bone mass remains crucial. Several techniques adequate in accuracy and precision exist to determine bone mass. The costs for these measurements are not negligible. Several pharmacologic regimens look promising for the prevention of osteoporosis and indeed for treatment of established osteoporosis. However, long-term data and clinical experience are warranted prior to establishing these pharmacological tools in the field of osteoporosis. For HRT and ERT such data are available. ERT and indeed HRT may halve the risk of osteoporotic fractures in women at least in current users. The effect at least on bone mass wears off after discontinuation of treatment but is never totally lost. In the interest of health care costs it is suggested that HRT could be started 15-20 years after the menopause and still provide protection for subsequent fractures.},
  author       = {Samsioe, Göran},
  issn         = {1600-0412},
  keyword      = {bone fragility,bone fracture,bone loss,bone mineral density,osteoporosis},
  language     = {eng},
  number       = {3},
  pages        = {189--199},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {Review Article: Osteoporosis - an update},
  url          = {http://dx.doi.org/10.3109/00016349709048140},
  volume       = {76},
  year         = {1997},
}