Advanced

Acute contractile effects of epidermal growth factor on bladder smooth muscles. An in vivo and in vitro study in rats

Vinter-Jensen, Lars; Kirik, Deniz LU ; Arner, Anders LU ; Nexo, Ebba and Uvelius, Bengt LU (1997) In Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00 31(3). p.231-235
Abstract
Chronic treatment with epidermal growth factor (EGF) stimulates growth of all wall layers of the urinary tract in pigs and rats. Herein, we investigated the acute effects of EGF on detrusor smooth muscle activity. For in vivo examination, awake rats received EGF (75 micrograms/kg) intravenously and detrusor smooth muscle activity was monitored cystometrically. The EGF bolus caused no alteration in diuresis but a doubling of the micturition frequency, a 25% increase in micturition pressures, and increased irregular baseline contractile activity. For in vitro examination detrusor smooth muscle strips were exposed to EGF (1 microgram/ml). EGF caused contraction and increase in the spontaneous activity. In conclusion, EGF increases rat... (More)
Chronic treatment with epidermal growth factor (EGF) stimulates growth of all wall layers of the urinary tract in pigs and rats. Herein, we investigated the acute effects of EGF on detrusor smooth muscle activity. For in vivo examination, awake rats received EGF (75 micrograms/kg) intravenously and detrusor smooth muscle activity was monitored cystometrically. The EGF bolus caused no alteration in diuresis but a doubling of the micturition frequency, a 25% increase in micturition pressures, and increased irregular baseline contractile activity. For in vitro examination detrusor smooth muscle strips were exposed to EGF (1 microgram/ml). EGF caused contraction and increase in the spontaneous activity. In conclusion, EGF increases rat detrusor smooth muscle contractile activity in vivo and in vitro. The finding suggests that a direct effect of EGF on bladder smooth muscles is part of the genesis to the growth of the detrusor smooth muscle observed after chronic EGF treatment. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bladder, muscle contraction, smooth muscle
in
Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00
volume
31
issue
3
pages
231 - 235
publisher
Taylor & Francis
external identifiers
  • pmid:9249884
  • scopus:0030738045
ISSN
0036-5599
DOI
10.3109/00365599709070339
language
English
LU publication?
yes
id
b381c4ae-193e-4eb2-82f5-af8f94194662 (old id 1112386)
date added to LUP
2008-07-22 10:31:23
date last changed
2017-02-22 11:44:30
@article{b381c4ae-193e-4eb2-82f5-af8f94194662,
  abstract     = {Chronic treatment with epidermal growth factor (EGF) stimulates growth of all wall layers of the urinary tract in pigs and rats. Herein, we investigated the acute effects of EGF on detrusor smooth muscle activity. For in vivo examination, awake rats received EGF (75 micrograms/kg) intravenously and detrusor smooth muscle activity was monitored cystometrically. The EGF bolus caused no alteration in diuresis but a doubling of the micturition frequency, a 25% increase in micturition pressures, and increased irregular baseline contractile activity. For in vitro examination detrusor smooth muscle strips were exposed to EGF (1 microgram/ml). EGF caused contraction and increase in the spontaneous activity. In conclusion, EGF increases rat detrusor smooth muscle contractile activity in vivo and in vitro. The finding suggests that a direct effect of EGF on bladder smooth muscles is part of the genesis to the growth of the detrusor smooth muscle observed after chronic EGF treatment.},
  author       = {Vinter-Jensen, Lars and Kirik, Deniz and Arner, Anders and Nexo, Ebba and Uvelius, Bengt},
  issn         = {0036-5599},
  keyword      = {Bladder,muscle contraction,smooth muscle},
  language     = {eng},
  number       = {3},
  pages        = {231--235},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00},
  title        = {Acute contractile effects of epidermal growth factor on bladder smooth muscles. An in vivo and in vitro study in rats},
  url          = {http://dx.doi.org/10.3109/00365599709070339},
  volume       = {31},
  year         = {1997},
}