Advanced

Apolipoprotein E genotyping in Alzheimer’s disease and frontotemporal dementia

Gustafson, Lars LU ; Abrahamson, Magnus LU ; Grubb, Anders LU ; Nilsson, Karin and Fex, Göran (1997) In Dementia and Geriatric Cognitive Disorders 8(4). p.240-243
Abstract
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are characterized by progressive neuronal loss and microvacuolization, although with different distributions of cortical involvement. In contrast to AD there is no amyloid, senile plaques or tangles in FTD. The involvement of chromosome 19 in AD has been associated with apoliprotein E (ApoE) and the epsi4 gene frequency has been related to increased risk and early onset of AD. Our analysis of frequency of the ApoE alleles in 38 patients with AD, 21 patients with FTD and 29 normal controls indicates an association of both AD and FTD with an increased frequency of the epsi4 allele and in AD also with homozygosity for epsi4. Our results might indicate that ApoE epsi4 is an important... (More)
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are characterized by progressive neuronal loss and microvacuolization, although with different distributions of cortical involvement. In contrast to AD there is no amyloid, senile plaques or tangles in FTD. The involvement of chromosome 19 in AD has been associated with apoliprotein E (ApoE) and the epsi4 gene frequency has been related to increased risk and early onset of AD. Our analysis of frequency of the ApoE alleles in 38 patients with AD, 21 patients with FTD and 29 normal controls indicates an association of both AD and FTD with an increased frequency of the epsi4 allele and in AD also with homozygosity for epsi4. Our results might indicate that ApoE epsi4 is an important aggravating and pathoplastic factor in the presence of genetic and other determinants for the development of AD or FTD. A significantly higher epsi2 frequency in our FTD material compared to AD and normals might also indicate a connection with the distribution of cortical degeneration. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Apolipoprotein E, Isoforms, Alzheimer's disease, Frontotemporal dementia
in
Dementia and Geriatric Cognitive Disorders
volume
8
issue
4
pages
240 - 243
publisher
Karger
external identifiers
  • scopus:0030920510
ISSN
1420-8008
DOI
10.1159/000106637
language
English
LU publication?
yes
id
44e2a954-7880-4bd4-8772-2961f44222d7 (old id 1112413)
date added to LUP
2008-07-22 11:22:15
date last changed
2017-10-01 03:54:30
@article{44e2a954-7880-4bd4-8772-2961f44222d7,
  abstract     = {Alzheimer's disease (AD) and frontotemporal dementia (FTD) are characterized by progressive neuronal loss and microvacuolization, although with different distributions of cortical involvement. In contrast to AD there is no amyloid, senile plaques or tangles in FTD. The involvement of chromosome 19 in AD has been associated with apoliprotein E (ApoE) and the epsi4 gene frequency has been related to increased risk and early onset of AD. Our analysis of frequency of the ApoE alleles in 38 patients with AD, 21 patients with FTD and 29 normal controls indicates an association of both AD and FTD with an increased frequency of the epsi4 allele and in AD also with homozygosity for epsi4. Our results might indicate that ApoE epsi4 is an important aggravating and pathoplastic factor in the presence of genetic and other determinants for the development of AD or FTD. A significantly higher epsi2 frequency in our FTD material compared to AD and normals might also indicate a connection with the distribution of cortical degeneration.},
  author       = {Gustafson, Lars and Abrahamson, Magnus and Grubb, Anders and Nilsson, Karin and Fex, Göran},
  issn         = {1420-8008},
  keyword      = {Apolipoprotein E,Isoforms,Alzheimer's disease,Frontotemporal dementia},
  language     = {eng},
  number       = {4},
  pages        = {240--243},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Apolipoprotein E genotyping in Alzheimer’s disease and frontotemporal dementia},
  url          = {http://dx.doi.org/10.1159/000106637},
  volume       = {8},
  year         = {1997},
}