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Association between Helicobacter pylori and gastric carcinoma in the city of Malmo, Sweden. A prospective study

Simán, Henrik LU ; Forsgren, Arne LU ; Berglund, Göran LU and Florén, Claes-Henrik LU (1997) In Scandinavian Journal of Gastroenterology 32(12). p.1215-1221
Abstract
BACKGROUND: We have investigated the association between Helicobacter pylori and gastric carcinoma through a nested case-control study in a single city. METHODS: From a cohort of 32,906 residents recruited from 1974 through 1992, 56 cases of gastric adenocarcinoma and 224 matched controls were selected. The mean interval between serum collection and diagnosis was 5.7 years. Frozen serum or plasma samples were analysed for IgG antibodies against H. pylori with an enzyme-linked immunosorbent assay. RESULTS: The overall seropositivity prevalence in gastric cancer cases was 82%, compared with 49% in controls, giving an odds ratio (OR) of 5.0 (95% confidence interval (CI), 2.2-11.5). Partial gastrectomy because of peptic ulcer 5 to 36 year... (More)
BACKGROUND: We have investigated the association between Helicobacter pylori and gastric carcinoma through a nested case-control study in a single city. METHODS: From a cohort of 32,906 residents recruited from 1974 through 1992, 56 cases of gastric adenocarcinoma and 224 matched controls were selected. The mean interval between serum collection and diagnosis was 5.7 years. Frozen serum or plasma samples were analysed for IgG antibodies against H. pylori with an enzyme-linked immunosorbent assay. RESULTS: The overall seropositivity prevalence in gastric cancer cases was 82%, compared with 49% in controls, giving an odds ratio (OR) of 5.0 (95% confidence interval (CI), 2.2-11.5). Partial gastrectomy because of peptic ulcer 5 to 36 year before diagnosis of gastric cancer could be a confounding factor. With exclusion of 10 such cases, H. pylori seropositivity among cases was 78%, as compared with 50% in matched controls (OR, 3.9; 95% CI, 1.7-9.2). Tumours of the cardia were not associated with H. pylori (OR, 0.92; 95% CI, 0.23-3.7), which is in contrast to tumours of the fundus, corpus, and antrum, which were significantly associated (OR, 11.1; 95% CI, 2.4-71.8). This difference in location was significant (P < 0.01). CONCLUSION: There is a significant association between prior infection with H. pylori and later development of gastric carcinoma, and the association is related to noncardia gastric cancer. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Gastric cancer, Helicobacter pylori, nested case—control study
in
Scandinavian Journal of Gastroenterology
volume
32
issue
12
pages
1215 - 1221
publisher
Taylor & Francis
external identifiers
  • pmid:9438319
  • scopus:0031465972
ISSN
1502-7708
DOI
10.3109/00365529709028150
language
English
LU publication?
yes
id
a703a22a-85c7-4788-80ef-3b9851991d61 (old id 1112484)
date added to LUP
2016-04-01 16:59:06
date last changed
2024-01-11 18:32:58
@article{a703a22a-85c7-4788-80ef-3b9851991d61,
  abstract     = {{BACKGROUND: We have investigated the association between Helicobacter pylori and gastric carcinoma through a nested case-control study in a single city. METHODS: From a cohort of 32,906 residents recruited from 1974 through 1992, 56 cases of gastric adenocarcinoma and 224 matched controls were selected. The mean interval between serum collection and diagnosis was 5.7 years. Frozen serum or plasma samples were analysed for IgG antibodies against H. pylori with an enzyme-linked immunosorbent assay. RESULTS: The overall seropositivity prevalence in gastric cancer cases was 82%, compared with 49% in controls, giving an odds ratio (OR) of 5.0 (95% confidence interval (CI), 2.2-11.5). Partial gastrectomy because of peptic ulcer 5 to 36 year before diagnosis of gastric cancer could be a confounding factor. With exclusion of 10 such cases, H. pylori seropositivity among cases was 78%, as compared with 50% in matched controls (OR, 3.9; 95% CI, 1.7-9.2). Tumours of the cardia were not associated with H. pylori (OR, 0.92; 95% CI, 0.23-3.7), which is in contrast to tumours of the fundus, corpus, and antrum, which were significantly associated (OR, 11.1; 95% CI, 2.4-71.8). This difference in location was significant (P &lt; 0.01). CONCLUSION: There is a significant association between prior infection with H. pylori and later development of gastric carcinoma, and the association is related to noncardia gastric cancer.}},
  author       = {{Simán, Henrik and Forsgren, Arne and Berglund, Göran and Florén, Claes-Henrik}},
  issn         = {{1502-7708}},
  keywords     = {{Gastric cancer; Helicobacter pylori; nested case—control study}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{1215--1221}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Journal of Gastroenterology}},
  title        = {{Association between Helicobacter pylori and gastric carcinoma in the city of Malmo, Sweden. A prospective study}},
  url          = {{http://dx.doi.org/10.3109/00365529709028150}},
  doi          = {{10.3109/00365529709028150}},
  volume       = {{32}},
  year         = {{1997}},
}