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Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets

Feet, B A; Brun, N C; Hellström-Westas, Lena LU ; Svenningsen, Niels W; Greisen, G and Saugstad, O D (1998) In Journal of Applied Physiology 84(4). p.1208-1216
Abstract
We tested the hypothesis that controlled hypoxemic resuscitation improves early cerebral metabolic and electrophysiological recovery in hypoxic newborn piglets. Severely hypoxic anesthetized piglets were randomly divided into three resuscitation groups: hypoxemic, 21% O2, and 100% O2 groups (8 in each group). The hypoxemic group was mechanically ventilated with 12-18% O2 adjusted to achieve a cerebral venous O2 saturation of 17-23% (baseline; 45 +/- 1%). Base excess (BE) reached -22 +/- 1 mM at the end of hypoxia. During a 2-h resuscitation period, no significant differences in time to recovery of electroencephalography (EEG), quality of EEG at recovery, or extracellular hypoxanthine concentrations in the cerebral cortex and striatum were... (More)
We tested the hypothesis that controlled hypoxemic resuscitation improves early cerebral metabolic and electrophysiological recovery in hypoxic newborn piglets. Severely hypoxic anesthetized piglets were randomly divided into three resuscitation groups: hypoxemic, 21% O2, and 100% O2 groups (8 in each group). The hypoxemic group was mechanically ventilated with 12-18% O2 adjusted to achieve a cerebral venous O2 saturation of 17-23% (baseline; 45 +/- 1%). Base excess (BE) reached -22 +/- 1 mM at the end of hypoxia. During a 2-h resuscitation period, no significant differences in time to recovery of electroencephalography (EEG), quality of EEG at recovery, or extracellular hypoxanthine concentrations in the cerebral cortex and striatum were found among the groups. BE and plasma hypoxanthine, however, normalized significantly more slowly during controlled hypoxemic resuscitation than during resuscitation with 21 or 100% O2. We conclude that early brain recovery during controlled hypoxemic resuscitation was as efficient as, but not superior to, recovery during resuscitation with 21 or 100% O2. The systemic metabolic recovery from hypoxia, however, was delayed during controlled hypoxemic resuscitation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
asphyxia, electroencephalography, near-infrared spectrophotometry, hypoxanthine, newborn piglets
in
Journal of Applied Physiology
volume
84
issue
4
pages
1208 - 1216
publisher
American Physiological Society
external identifiers
  • pmid:9516186
  • scopus:0031898449
ISSN
1522-1601
language
English
LU publication?
yes
id
3e37c679-9f85-4aae-b10e-c260a8b121af (old id 1112715)
alternative location
http://jap.physiology.org/cgi/content/full/84/4/1208
date added to LUP
2008-07-11 09:27:41
date last changed
2017-08-06 03:51:19
@article{3e37c679-9f85-4aae-b10e-c260a8b121af,
  abstract     = {We tested the hypothesis that controlled hypoxemic resuscitation improves early cerebral metabolic and electrophysiological recovery in hypoxic newborn piglets. Severely hypoxic anesthetized piglets were randomly divided into three resuscitation groups: hypoxemic, 21% O2, and 100% O2 groups (8 in each group). The hypoxemic group was mechanically ventilated with 12-18% O2 adjusted to achieve a cerebral venous O2 saturation of 17-23% (baseline; 45 +/- 1%). Base excess (BE) reached -22 +/- 1 mM at the end of hypoxia. During a 2-h resuscitation period, no significant differences in time to recovery of electroencephalography (EEG), quality of EEG at recovery, or extracellular hypoxanthine concentrations in the cerebral cortex and striatum were found among the groups. BE and plasma hypoxanthine, however, normalized significantly more slowly during controlled hypoxemic resuscitation than during resuscitation with 21 or 100% O2. We conclude that early brain recovery during controlled hypoxemic resuscitation was as efficient as, but not superior to, recovery during resuscitation with 21 or 100% O2. The systemic metabolic recovery from hypoxia, however, was delayed during controlled hypoxemic resuscitation.},
  author       = {Feet, B A and Brun, N C and Hellström-Westas, Lena and Svenningsen, Niels W and Greisen, G and Saugstad, O D},
  issn         = {1522-1601},
  keyword      = {asphyxia,electroencephalography,near-infrared spectrophotometry,hypoxanthine,newborn piglets},
  language     = {eng},
  number       = {4},
  pages        = {1208--1216},
  publisher    = {American Physiological Society},
  series       = {Journal of Applied Physiology},
  title        = {Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets},
  volume       = {84},
  year         = {1998},
}