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Amplification of 12q13 and 12q15 sequences in a sclerosing epithelioid fibrosarcoma

Gisselsson, D LU ; Andreasson, P; Meis-Kindblom, J M; Kindblom, L G; Mertens, F LU and Mandahl, N LU (1998) In Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00 107(2). p.102-106
Abstract

Sclerosing epithelioid fibrosarcoma (SEF) is a recently described entity. It is a low-grade sarcoma that occurs primarily in the deep soft tissues of the extremities of adults. It may histologically simulate benign lesions such as fibroma and myxoma or malignancies such as sclerosing carcinoma and lymphoma, extraskeletal myxoid chondrosarcoma, clear cell sarcoma of tendons and aponeuroses, and synovial sarcoma, depending on the lesion's cellularity, degree of fibrosis, and amount of myxoid matrix. There are no previously published cytogenetic studies of this tumor. We found the karyotype 40-45,XY,add(9)(p13),add(10)(p11),-12,-13,-18,add(18)(q11),add(20)(q11) in a SEF of a 14-year-old boy, by using chromosome banding. Fluorescence in... (More)

Sclerosing epithelioid fibrosarcoma (SEF) is a recently described entity. It is a low-grade sarcoma that occurs primarily in the deep soft tissues of the extremities of adults. It may histologically simulate benign lesions such as fibroma and myxoma or malignancies such as sclerosing carcinoma and lymphoma, extraskeletal myxoid chondrosarcoma, clear cell sarcoma of tendons and aponeuroses, and synovial sarcoma, depending on the lesion's cellularity, degree of fibrosis, and amount of myxoid matrix. There are no previously published cytogenetic studies of this tumor. We found the karyotype 40-45,XY,add(9)(p13),add(10)(p11),-12,-13,-18,add(18)(q11),add(20)(q11) in a SEF of a 14-year-old boy, by using chromosome banding. Fluorescence in situ hybridization showed that both the add(10) and the add(18) contained amplified sequences from 12q13 and 12q15, including the HMGIC gene. Chromosome 18 material was present in the add(9) and terminally in the add(10). The karyotype of this case indicates that SEF is unrelated to extraskeletal myxoid chondrosarcoma, clear cell sarcoma, and synovial sarcoma. When compared with the findings in other soft tissue tumors such as well-differentiated liposarcoma and low-grade malignant fibrous histiocytoma, the chromosome banding and in situ hybridization data add support to the notion that SEF is a relatively low grade variant of fibrosarcoma.

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publication status
published
subject
keywords
Adolescent, Chromosomes, Human, Pair 10, Chromosomes, Human, Pair 12, Fibrosarcoma, Foot Diseases, Humans, In Situ Hybridization, Fluorescence, Karyotyping, Male, Translocation, Genetic, Case Reports, Journal Article, Research Support, Non-U.S. Gov't
in
Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00
volume
107
issue
2
pages
5 pages
publisher
Elsevier
external identifiers
  • pmid:9844602
  • scopus:0032403202
ISSN
0165-4608
DOI
10.1016/S0165-4608(98)00098-3
language
English
LU publication?
yes
id
5738c2fb-0147-407f-a405-0d4b48d9de99 (old id 1112888)
date added to LUP
2008-07-11 13:53:52
date last changed
2017-07-30 04:26:03
@article{5738c2fb-0147-407f-a405-0d4b48d9de99,
  abstract     = {<p>Sclerosing epithelioid fibrosarcoma (SEF) is a recently described entity. It is a low-grade sarcoma that occurs primarily in the deep soft tissues of the extremities of adults. It may histologically simulate benign lesions such as fibroma and myxoma or malignancies such as sclerosing carcinoma and lymphoma, extraskeletal myxoid chondrosarcoma, clear cell sarcoma of tendons and aponeuroses, and synovial sarcoma, depending on the lesion's cellularity, degree of fibrosis, and amount of myxoid matrix. There are no previously published cytogenetic studies of this tumor. We found the karyotype 40-45,XY,add(9)(p13),add(10)(p11),-12,-13,-18,add(18)(q11),add(20)(q11) in a SEF of a 14-year-old boy, by using chromosome banding. Fluorescence in situ hybridization showed that both the add(10) and the add(18) contained amplified sequences from 12q13 and 12q15, including the HMGIC gene. Chromosome 18 material was present in the add(9) and terminally in the add(10). The karyotype of this case indicates that SEF is unrelated to extraskeletal myxoid chondrosarcoma, clear cell sarcoma, and synovial sarcoma. When compared with the findings in other soft tissue tumors such as well-differentiated liposarcoma and low-grade malignant fibrous histiocytoma, the chromosome banding and in situ hybridization data add support to the notion that SEF is a relatively low grade variant of fibrosarcoma.</p>},
  author       = {Gisselsson, D and Andreasson, P and Meis-Kindblom, J M and Kindblom, L G and Mertens, F and Mandahl, N},
  issn         = {0165-4608},
  keyword      = {Adolescent,Chromosomes, Human, Pair 10,Chromosomes, Human, Pair 12,Fibrosarcoma,Foot Diseases,Humans,In Situ Hybridization, Fluorescence,Karyotyping,Male,Translocation, Genetic,Case Reports,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {2},
  pages        = {102--106},
  publisher    = {Elsevier},
  series       = {Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00},
  title        = {Amplification of 12q13 and 12q15 sequences in a sclerosing epithelioid fibrosarcoma},
  url          = {http://dx.doi.org/10.1016/S0165-4608(98)00098-3},
  volume       = {107},
  year         = {1998},
}