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Insulin-like growth factor-1 in relation to adult weight and birth weight in healthy nulliparous women

Jernström, H LU and Olsson, H LU (1998) In International Journal of Gynecology & Obstetrics 62(1). p.8-11
Abstract

OBJECTIVE: To study the relationships between plasma insulin-like growth factor-1 (IGF-1) concentrations and birth weight, current weight and other constitutional factors among healthy, nulliparous women aged 19-25 years.

DESIGN AND METHODS: Forty healthy female university students aged 19-25 years volunteered for this study. They had never been pregnant and were not using oral contraceptives (OCs). Blood samples were drawn both in the follicular and luteal cycle phases (08:00-10:00 h) and weight, height, and waist-hip ratio were measured at the same time by one person (H.J). Information regarding age, birth weight, OC use, etc. was obtained from a questionnaire filled out by the women. Plasma IGF-1 concentrations were analyzed by... (More)

OBJECTIVE: To study the relationships between plasma insulin-like growth factor-1 (IGF-1) concentrations and birth weight, current weight and other constitutional factors among healthy, nulliparous women aged 19-25 years.

DESIGN AND METHODS: Forty healthy female university students aged 19-25 years volunteered for this study. They had never been pregnant and were not using oral contraceptives (OCs). Blood samples were drawn both in the follicular and luteal cycle phases (08:00-10:00 h) and weight, height, and waist-hip ratio were measured at the same time by one person (H.J). Information regarding age, birth weight, OC use, etc. was obtained from a questionnaire filled out by the women. Plasma IGF-1 concentrations were analyzed by radio immunoassay.

RESULTS: In a multivariate model including birth weight, current weight and age, IGF-1 was significantly inversely associated with birth weight in both cycle phases, while current weight was positively associated with IGF-1 in both cycle phases although only significantly so in the follicular phase. IGF-1 concentrations in both cycle phases showed a non-significant decrease with age.

CONCLUSION: In this group of 19-25-year-old healthy nulliparous women IGF-1 displayed a significant inverse association with birth weight in both cycle phases given that the current weight was adjusted for, while current weight was positively related to IGF-1 concentrations.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Birth Weight, Body Weight, Female, Follicular Phase, Humans, Insulin-Like Growth Factor I, Luteal Phase, Multivariate Analysis
in
International Journal of Gynecology & Obstetrics
volume
62
issue
1
pages
8 pages
publisher
Elsevier
external identifiers
  • pmid:9722119
  • scopus:0031855602
ISSN
1879-3479
DOI
10.1016/S0020-7292(98)00060-5
language
English
LU publication?
yes
id
ba7f9432-732f-4057-b338-7b9ce375e286 (old id 1112995)
date added to LUP
2008-07-14 10:23:38
date last changed
2017-02-26 03:24:29
@article{ba7f9432-732f-4057-b338-7b9ce375e286,
  abstract     = {<p>OBJECTIVE: To study the relationships between plasma insulin-like growth factor-1 (IGF-1) concentrations and birth weight, current weight and other constitutional factors among healthy, nulliparous women aged 19-25 years.</p><p>DESIGN AND METHODS: Forty healthy female university students aged 19-25 years volunteered for this study. They had never been pregnant and were not using oral contraceptives (OCs). Blood samples were drawn both in the follicular and luteal cycle phases (08:00-10:00 h) and weight, height, and waist-hip ratio were measured at the same time by one person (H.J). Information regarding age, birth weight, OC use, etc. was obtained from a questionnaire filled out by the women. Plasma IGF-1 concentrations were analyzed by radio immunoassay.</p><p>RESULTS: In a multivariate model including birth weight, current weight and age, IGF-1 was significantly inversely associated with birth weight in both cycle phases, while current weight was positively associated with IGF-1 in both cycle phases although only significantly so in the follicular phase. IGF-1 concentrations in both cycle phases showed a non-significant decrease with age.</p><p>CONCLUSION: In this group of 19-25-year-old healthy nulliparous women IGF-1 displayed a significant inverse association with birth weight in both cycle phases given that the current weight was adjusted for, while current weight was positively related to IGF-1 concentrations.</p>},
  author       = {Jernström, H and Olsson, H},
  issn         = {1879-3479},
  keyword      = {Adult,Birth Weight,Body Weight,Female,Follicular Phase,Humans,Insulin-Like Growth Factor I,Luteal Phase,Multivariate Analysis},
  language     = {eng},
  number       = {1},
  pages        = {8--11},
  publisher    = {Elsevier},
  series       = {International Journal of Gynecology & Obstetrics},
  title        = {Insulin-like growth factor-1 in relation to adult weight and birth weight in healthy nulliparous women},
  url          = {http://dx.doi.org/10.1016/S0020-7292(98)00060-5},
  volume       = {62},
  year         = {1998},
}