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BRCA1-positive patients are small for gestational age compared with their unaffected relatives

Jernström, H LU ; Johannsson, O LU ; Borg, A LU ; Ivarsson, H LU and Olsson, H LU (1998) In European Journal of Cancer 34(3). p.71-368
Abstract

The BRCA1 gene is thought to exert its main function early in life. We, therefore, studied the effects of BRCA1 mutations on birth weight and birth length. This was carried out by comparing 33 women with and without mutations. Birth weight and length were obtained from a self-administered questionnaire. BRCA1 mutations carriers had a significantly lower birth weight (P = 0.0041) compared with non-carriers, after adjustment for gestational age. They were also significantly shorter at birth compared with their unaffected relatives (P = 0.0060), after adjustment for gestational age. The BRCA1 gene thus seems to influence the carriers in utero. The findings could imply that humans heterozygotic for the BRCA1 mutations may be influenced by... (More)

The BRCA1 gene is thought to exert its main function early in life. We, therefore, studied the effects of BRCA1 mutations on birth weight and birth length. This was carried out by comparing 33 women with and without mutations. Birth weight and length were obtained from a self-administered questionnaire. BRCA1 mutations carriers had a significantly lower birth weight (P = 0.0041) compared with non-carriers, after adjustment for gestational age. They were also significantly shorter at birth compared with their unaffected relatives (P = 0.0060), after adjustment for gestational age. The BRCA1 gene thus seems to influence the carriers in utero. The findings could imply that humans heterozygotic for the BRCA1 mutations may be influenced by the mutations during development in utero.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Adult, BRCA1 Protein, Birth Weight, Body Height, Female, Heterozygote, Humans, Infant, Newborn, Infant, Small for Gestational Age, Mutation, Pedigree
in
European Journal of Cancer
volume
34
issue
3
pages
4 pages
publisher
Elsevier
external identifiers
  • pmid:9640224
  • scopus:0032007141
ISSN
1879-0852
DOI
10.1016/S0959-8049(97)10088-0
language
English
LU publication?
yes
id
e29ded71-a7d7-4782-a6d9-b6341bbb2f55 (old id 1112997)
date added to LUP
2008-07-14 10:26:03
date last changed
2017-01-01 04:40:11
@article{e29ded71-a7d7-4782-a6d9-b6341bbb2f55,
  abstract     = {<p>The BRCA1 gene is thought to exert its main function early in life. We, therefore, studied the effects of BRCA1 mutations on birth weight and birth length. This was carried out by comparing 33 women with and without mutations. Birth weight and length were obtained from a self-administered questionnaire. BRCA1 mutations carriers had a significantly lower birth weight (P = 0.0041) compared with non-carriers, after adjustment for gestational age. They were also significantly shorter at birth compared with their unaffected relatives (P = 0.0060), after adjustment for gestational age. The BRCA1 gene thus seems to influence the carriers in utero. The findings could imply that humans heterozygotic for the BRCA1 mutations may be influenced by the mutations during development in utero.</p>},
  author       = {Jernström, H and Johannsson, O and Borg, A and Ivarsson, H and Olsson, H},
  issn         = {1879-0852},
  keyword      = {Adult,BRCA1 Protein,Birth Weight,Body Height,Female,Heterozygote,Humans,Infant, Newborn,Infant, Small for Gestational Age,Mutation,Pedigree},
  language     = {eng},
  number       = {3},
  pages        = {71--368},
  publisher    = {Elsevier},
  series       = {European Journal of Cancer},
  title        = {BRCA1-positive patients are small for gestational age compared with their unaffected relatives},
  url          = {http://dx.doi.org/10.1016/S0959-8049(97)10088-0},
  volume       = {34},
  year         = {1998},
}